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Biology and Biochemistry

D-Index
85
Citations
39261
World Ranking
3074
National Ranking
1556

Overview

Matthew J. Huentelman is affiliated with the Translational Genomics Research Institute in the United States. Their research spans multiple disciplines, primarily focusing on medicine and biochemistry, genetics, and molecular biology. Within these broad fields, they have contributed extensively to subfields such as molecular biology, neurology, genetics, psychiatry and mental health, and physiology.

The topics most frequently addressed in their work include:

  • Dementia and Cognitive Impairment Research
  • Alzheimer's disease research and treatments
  • Epigenetics and DNA Methylation
  • Genetic Associations and Epidemiology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Functional Brain Connectivity Studies
  • Long-Term Effects of COVID-19

Several recent publications reflect the diversity and focus of their research:

  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study, 2020, Nature Communications
  • Development of a mobile low-field MRI scanner, 2022, Scientific Reports
  • Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • DNA Methylation and Expression Profiles of Whole Blood in Parkinson's Disease, 2021, Frontiers in Genetics
  • Extracellular microRNAs in blood differentiate between ischaemic and haemorrhagic stroke subtypes, 2020, Journal of Extracellular Vesicles

Huentelman collaborates regularly with several researchers, including Ignazio S. Piras, Marcus Naymik, Joshua S. Talboom, Vinodh Narayanan, and Thomas G. Beach. These frequent co-authors appear in numerous joint publications, signifying ongoing collaborative efforts.

Their work is published predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • Scientific Reports
  • Gerontology
  • International Journal of Molecular Sciences

Throughout their career, Matthew J. Huentelman has produced a significant body of research aimed at understanding neurodegenerative processes, genetic markers, and neurological disease mechanisms, with particular attention to dementia, Alzheimer's disease, and the effects of COVID-19 on the brain. Their extensive publication record and collaborations emphasize a multidisciplinary approach combining genomics, neurology, and molecular biology.

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Recessive Symptomatic Focal Epilepsy and Mutant Contactin-Associated Protein-like 2

    Kevin A. Strauss;Erik G. Puffenberger;Matthew J. Huentelman;Steven Gottlieb

  • Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

    Eric M Reiman;Yakeel T Quiroz;Yakeel T Quiroz;Adam S Fleisher;Kewei Chen

  • GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers

    Eric M. Reiman;Jennifer A. Webster;Amanda J. Myers;Amanda J. Myers;John Hardy;John Hardy

  • Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

    Joseph F. Arboleda-Velasquez;Francisco Lopera;Michael O’Hare;Santiago Delgado-Tirado

  • A survey of genetic human cortical gene expression.

    Amanda J Myers;Amanda J Myers;J Raphael Gibbs;Jennifer A Webster;Kristen Rohrer

  • Common Kibra Alleles Are Associated with Human Memory Performance

    Andreas Papassotiropoulos;Andreas Papassotiropoulos;Dietrich A. Stephan;Matthew J. Huentelman;Frederic J. Hoerndli

  • Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.

    Andrew J. Saykin;Li Shen;Tatiana M. Foroud;Steven G. Potkin

  • Necroptosis activation in Alzheimer's disease

    Antonella Caccamo;Caterina Branca;Ignazio S. Piras;Eric Ferreira

  • Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    Eric M Reiman;Joseph F Arboleda-Velasquez;Yakeel T Quiroz;Matthew J Huentelman

  • Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

    Li Shen;Sungeun Kim;Shannon L. Risacher;Kwangsik Nho

  • A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.

    A D Roses;M W Lutz;M W Lutz;H Amrine-Madsen;A M Saunders;A M Saunders

  • Identification of genetic variants using bar-coded multiplexed sequencing

    David W Craig;John V Pearson;Szabolcs Szelinger;Aswin Sekar

  • Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

    Gary W. Beecham;Kara Hamilton;Adam C. Naj;Eden R. Martin

  • Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

    Jennifer A. Webster;Jennifer A. Webster;J. Raphael Gibbs;J. Raphael Gibbs;Jennifer Clarke;Monika Ray

  • Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis

    Travis Dunckley;Matthew J. Huentelman;David W. Craig;John V. Pearson

Frequent Co-Authors

Jason J. Corneveaux
Jason J. Corneveaux Translational Genomics Research Institute
David Craig
David Craig University of Southern California
Eric M. Reiman
Eric M. Reiman Arizona State University
Philip L. De Jager
Philip L. De Jager Columbia University
Amanda J. Myers
Amanda J. Myers University of Miami
Tatiana Foroud
Tatiana Foroud Indiana University
John Hardy
John Hardy University College London
Andrew J. Saykin
Andrew J. Saykin Indiana University
David A. Bennett
David A. Bennett Rush University Medical Center
Li Shen
Li Shen University of Pennsylvania

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