World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
9892
World Ranking
17964
National Ranking
7351

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Stephen Desiderio is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple disciplines within medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Key subfields include molecular biology, immunology, infectious diseases, neurology, and biological psychiatry.

The scientist's work focuses on several main topics, notably tryptophan and brain disorders, the role of immune cells in cancer, SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, the complement system in diseases, CRISPR and genetic engineering, and plant reproductive biology.

Notable recent papers include:

  • IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function (2022, JCI Insight)
  • Binding and allosteric transmission of histone H3 Lys-4 trimethylation to the recombinase RAG-1 are separable functions of the RAG-2 plant homeodomain finger (2020, Journal of Biological Chemistry)
  • Abstract 2765: The indoleamine 2,3 dioxygenase-1 pathway drives intratumoral B cell maintenance (2021, Cancer Research)
  • The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance (2021, bioRxiv [Cold Spring Harbor Laboratory])

Stephen Desiderio frequently collaborates with several researchers, including:

  • John E. Niederhuber
  • Burles A. Johnson
  • Adam K. Aragaki
  • Donna M. Williams
  • Ophelia Rogers

Their research has been published in venues such as JCI Insight, Journal of Biological Chemistry, Cancer Research, and bioRxiv hosted by Cold Spring Harbor Laboratory.

Stephen Desiderio is a member of the Association of American Physicians, indicating recognition within the medical community.

Best Publications

  • Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

    George D. Yancopoulos;Stephen V. Desiderio;Michael Paskind;John F. Kearney

  • RAG Mutations in Human B Cell-Negative SCID

    Klaus Schwarz;George H. Gauss;Leopold Ludwig;Ulrich Pannicke

  • Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

    Stephen V. Desiderio;George D. Yancopoulos;Michael Paskind;Elise Thomas;Elise Thomas

  • NetPath: a public resource of curated signal transduction pathways

    Kumaran Kandasamy;S. Sujatha Mohan;Rajesh Raju;Shivakumar Keerthikumar

  • itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2

    Janet D. Siliciano;Theresa A. Morrow;Stephen V. Desiderio

  • Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

    Susan M. Dymecki;John E. Niederhuber;Stephen V. Desiderio

  • A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement

    Yun Liu;Ramesh Subrahmanyam;Tirtha Chakraborty;Ranjan Sen

  • Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

    Weei Chin Lin;Stephen Desiderio

  • A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle

    Zhong Li;Dominic I. Dordai;Jinhak Lee;Stephen Desiderio

  • BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.

    Weiyi Yang;Stephen Desiderio

  • Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

    Weei Chin Lin;Stephen Desiderio

  • Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands.

    Mark D. Challberg;Stephen V. Desiderio;Thomas J. Kelly

  • Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

    Joo Yeon Yoo;David L. Huso;Daniel Nathans;Stephen Desiderio

  • Construction of human activity-based phosphorylation networks.

    Robert H Newman;Robert H Newman;Jianfei Hu;Hee-Sool Rho;Zhi Xie

  • V(D)J Recombination Signal Recognition: Distinct, Overlapping DNA–Protein Contacts in Complexes Containing RAG1 with and without RAG2

    Patrick C. Swanson;Stephen Desiderio

  • Ubiquitylation of RAG-2 by Skp2-SCF Links Destruction of the V(D)J Recombinase to the Cell Cycle

    Hao Jiang;Fu Chung Chang;Ashley E. Ross;Jihyun Lee

  • Cyclin A/CDK2 Regulates V(D)J Recombination by Coordinating RAG-2 Accumulation and DNA Repair

    Jinhak Lee;Stephen Desiderio

  • Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein

    Stephen V. Desiderio;Thomas J. Kelly

  • Innate and acquired immunity intersect in a global view of the acute-phase response.

    Joo Yeon Yoo;Stephen Desiderio

  • RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.

    Patrick C. Swanson;Stephen Desiderio

Frequent Co-Authors

Akhilesh Pandey
Akhilesh Pandey Mayo Clinic
Janet D. Siliciano
Janet D. Siliciano Johns Hopkins University School of Medicine
Donald Small
Donald Small Johns Hopkins University
Christine A. Kozak
Christine A. Kozak National Institutes of Health
Gary D. Bader
Gary D. Bader University of Toronto
Ruhong Zhou
Ruhong Zhou Columbia University
Thomas J. Kelly
Thomas J. Kelly Memorial Sloan Kettering Cancer Center
Seth Blackshaw
Seth Blackshaw Johns Hopkins University School of Medicine
Michael Reth
Michael Reth University of Freiburg
David L. Huso
David L. Huso Johns Hopkins University

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