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Biology and Biochemistry

D-Index
71
Citations
18997
World Ranking
6610
National Ranking
3078

Overview

George N. DeMartino is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans several subfields within the broader discipline of molecular and cellular life sciences, including Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Cancer Research, and Immunology.

The primary focus of their research involves the ubiquitin-proteasome system, with particular interest in protease and inhibitor mechanisms as well as biochemical and molecular research methodologies. Additional topics covered in their work include endoplasmic reticulum stress and disease, neuroscience and neuropharmacology research, mitochondrial function and pathology, and socioeconomic issues such as income, poverty, and inequality.

Selected recent publications by George N. DeMartino include:

  • "Economics for an uncertain world," 2023, World Development
  • "Ηigh-resolution structure of mammalian PI31-20S proteasome complex reveals mechanism of proteasome inhibition," 2023, Journal of Biological Chemistry
  • "Highly conserved shifts in ubiquitin-proteasome system (UPS) activity drive mitochondrial remodeling during quiescence," 2022, Nature Communications
  • "Palmitoylated Proteins in Dendritic Spine Remodeling," 2020, Frontiers in Synaptic Neuroscience
  • "Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes," 2024, Biochemistry

The scientist often collaborates with researchers in related fields. Frequent co-authors include Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell.

Key publication venues for their work feature prominently the Journal of Biological Chemistry, with 37 publications, followed by contributions to bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, SSRN Electronic Journal, and World Development.

Best Publications

  • Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

    Dorothy E. Croall;George N. Demartino

  • The proteasome, a novel protease regulated by multiple mechanisms.

    George N. DeMartino;Clive A. Slaughter

  • Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

    C P Ma;C A Slaughter;G N DeMartino

  • Dynamic Association of Proteasomal Machinery with the Centrosome

    W. Christian Wigley;Rosalind P. Fabunmi;Min Goo Lee;Christopher R. Marino

  • Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome.

    Y. Amy Lam;Wei Xu;George N. DeMartino;Robert E. Cohen

  • Polyglutamine-Expanded Androgen Receptors Form Aggregates That Sequester Heat Shock Proteins, Proteasome Components and SRC-1, and Are Suppressed by the HDJ-2 Chaperone

    David L. Stenoien;Chris J. Cummings;Henry P. Adams;Maureen G. Mancini

  • Endoproteolytic activity of the proteasome.

    Chang Wei Liu;Michael J. Corboy;George N. DeMartino;Philip J. Thomas

  • Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.

    Jantje M Gerdes;Yangfan Liu;Norann A Zaghloul;Carmen C Leitch

  • Intracellular localization of proteasomes

    Cezary Wójcik;George N. DeMartino

  • Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome

    Li Lin;George N DeMartino;Warner C Greene

  • Lewy-body formation is an aggresome-related process: a hypothesis

    C Warren Olanow;Daniel P Perl;George N DeMartino;Kevin St P McNaught

  • Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation

    Joanna Bloom;Virginia Amador;Francesca Bartolini;George DeMartino

  • Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

    Mary C. Beckerle;Keith Burridge;George N. DeMartino;Dorothy E. Croall

  • Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

    Tingting Yao;Ling Song;Wei Xu;George N. DeMartino

  • Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

    Nien Pei Tsai;Julia R. Wilkerson;Weirui Guo;Marina A. Maksimova

  • RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis.

    Cezary Wójcik;Mihiro Yano;Mihiro Yano;George N. DeMartino

  • PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

    Anil K. Agarwal;Chao Xing;George N. DeMartino;Dario Mizrachi

  • Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome

    Ma Chu-Ping;James H. Vu;Rita J. Proske;Clive A. Slaughter

  • A Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation IMPLICATIONS FOR PATHOGENESIS OF PARKINSON DISEASE

    Chang Wei Liu;Benoit I. Giasson;Karen A. Lewis;Virginia M. Lee

  • Proteasomes: Machines for All Reasons

    George N. DeMartino;Thomas G. Gillette

Frequent Co-Authors

Clive A. Slaughter
Clive A. Slaughter University of Georgia
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Philip J. Thomas
Philip J. Thomas The University of Texas Southwestern Medical Center
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Chin Ha Chung
Chin Ha Chung Seoul National University
Michele Pagano
Michele Pagano New York University
Nahum Sonenberg
Nahum Sonenberg McGill University
P. Darrell Neufer
P. Darrell Neufer East Carolina University
Philip A. Beachy
Philip A. Beachy Stanford University
Alfred L. Goldberg
Alfred L. Goldberg Harvard University

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