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Molecular Biology

D-Index
119
Citations
51223
World Ranking
272
National Ranking
161

Overview

Jonathan A. Cooper is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research encompasses a broad range of topics within biochemistry, genetics, and molecular biology, with significant work in medicine.

The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their research has focused extensively on subfields such as:

  • Molecular Biology
  • Cell Biology
  • Immunology and Allergy
  • Oncology
  • Radiology, Nuclear Medicine and Imaging

Jonathan A. Cooper's work explores several main topics, including:

  • Cell Adhesion Molecules Research
  • Cellular Mechanics and Interactions
  • Protein Kinase Regulation and GTPase Signaling
  • Ubiquitin and proteasome pathways
  • Glycosylation and Glycoproteins Research
  • Cellular transport and secretion
  • Hippo pathway signaling and YAP/TAZ

Their recent publications highlight ongoing investigations into molecular and cellular processes. Some notable papers include:

  • "Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development," 2020, published in Molecular and Cellular Biology
  • "Cas phosphorylation regulates focal adhesion assembly," 2023, published in eLife
  • "SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma," 2024, published in Science Translational Medicine
  • "A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics," 2021, published in eLife
  • "Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration," 2024, published in Scientific Reports

Frequent coauthors in their collaborations include:

  • Saurav Kumar
  • Christopher E. Simpkins
  • Dayoung Kim
  • Amanda Stainer
  • Julien Dubrulle

Jonathan A. Cooper has published primarily in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Science Translational Medicine
  • Molecular and Cellular Biology
  • Scientific Reports

Best Publications

  • Protein-tyrosine kinases.

    Tony Hunter;Jonathan A. Cooper

  • Mammalian Ras interacts directly with the serine/threonine kinase Raf

    Anne B. Vojtek;Stanley M. Hollenberg;Jonathan A. Cooper

  • Regulation, substrates and functions of src.

    Megan T. Brown;Jonathan A. Cooper

  • Detection and quantification of phosphotyrosine in proteins.

    Jonathan A. Cooper;Bartholomew M. Sefton;Tony Hunter

  • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

    Andrew Jan Waskiewicz;Andrea Flynn;Christopher G. Proud;Jonathan A. Cooper;Jonathan A. Cooper

  • Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

    Thomas Hiesberger;Marion Trommsdorff;Brian W Howell;Andre Goffinet

  • Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

    Wiebe Kruijer;Jonathan A. Cooper;Tony Hunter;Inder M. Verma

  • Src family kinases are required for integrin but not PDGFR signal transduction

    Richard A. Klinghoffer;Christoph Sachsenmaier;Jonathan A. Cooper;Philippe Soriano

  • C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

    C Cochet;G N Gill;J Meisenhelder;J A Cooper

  • Neuronal position in the developing brain is regulated by mouse disabled-1

    Brian W. Howell;Richard Hawkes;Philippe Soriano;Jonathan A. Cooper

  • Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

    Tony Hunter;Nicholas Ling;Jonathan A. Cooper

  • Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src.

    Shigeyuki Nada;Masato Okada;Alasdair MacAuley;Jonathan A. Cooper

  • Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

    Tony Hunter;Jonathan A. Cooper

  • Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

    Andrew Jan Waskiewicz;Jonathan A Cooper

  • Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

    Michael Sheldon;Dennis S. Rice;Gabriella D'Arcangelo;Hiroyuki Yoneshima

  • The when and how of Src regulation

    Jonathan A. Cooper;Brian Howell

  • Tyr527 is phosphorylated in pp60c-src: implications for regulation.

    Jonathan A. Cooper;Kathleen L. Gould;Christine A. Cartwright;Tony Hunter

  • Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins.

    Andrius Kazlauskas;Jonathan A. Cooper

  • A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

    Wei Li;R. Nishimura;A. Kashishian;A. G. Batzer

  • Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.

    Andrew Jan Waskiewicz;Jeffrey C. Johnson;Bennett Penn;Bennett Penn;Malathy Mahalingam

Frequent Co-Authors

Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Irwin D. Bernstein
Irwin D. Bernstein Fred Hutchinson Cancer Research Center
Bartholomew M. Sefton
Bartholomew M. Sefton Salk Institute for Biological Studies
Bryan A. Ballif
Bryan A. Ballif University of Vermont
Kathleen L. Gould
Kathleen L. Gould Vanderbilt University
Philippe Soriano
Philippe Soriano Icahn School of Medicine at Mount Sinai
Takanori Kigawa
Takanori Kigawa RIKEN Center for Biosystems Dynamics Research
Ernest D. Laue
Ernest D. Laue University of Cambridge
Koji Takio
Koji Takio University of Washington
Tony Roscioli
Tony Roscioli University of New South Wales

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