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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
26413
World Ranking
2586
National Ranking
45

Medicine

D-Index
88
Citations
26616
World Ranking
13226
National Ranking
504

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Luigi Frati is affiliated with Sapienza University of Rome in Italy, where their research spans multiple fields within medicine and biochemistry. Their work emphasizes molecular biology and has made contributions to cardiology, cancer research, infectious diseases, and epidemiology.

The scientist's recent publications demonstrate a focus on cellular and molecular mechanisms across various biomedical topics. Notable papers include:

  • Beneficial effects of a combination of natural product activators of autophagy on endothelial cells and platelets, 2021, British Journal of Pharmacology
  • Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment, 2022, European Journal of Medicinal Chemistry
  • Age-dependent NK cell dysfunctions in severe COVID-19 patients, 2022, Frontiers in Immunology
  • MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation, 2023, Cellular and Molecular Life Sciences
  • Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy, 2025, European Heart Journal - Cardiovascular Pharmacotherapy

The core topics addressed by Luigi Frati's research include:

  • Cancer, Hypoxia, and Metabolism
  • COVID-19 Clinical Research Studies
  • Autophagy in Disease and Therapy
  • ATP Synthase and ATPases Research
  • Biochemical and Molecular Research
  • Immune Cell Function and Interaction
  • COVID-19 and Mental Health

Luigi Frati frequently collaborates with other researchers. Some of the most common coauthors are:

  • Sebastiano Sciarretta (4 collaborations)
  • Giacomo Frati (3 collaborations)
  • Roberto Carnevale (2 collaborations)
  • Sonia Schiavon (2 collaborations)
  • Maurizio Forte (2 collaborations)

Their work is published in a range of journals, with recurrent publications in:

  • Panminerva Medica (2 publications)
  • British Journal of Pharmacology (1 publication)
  • European Journal of Medicinal Chemistry (1 publication)
  • Frontiers in Immunology (1 publication)
  • Cellular and Molecular Life Sciences (1 publication)

Luigi Frati's main fields of study are medicine and biochemistry, genetics, and molecular biology, with 14 and 11 publications respectively. Their subfields include molecular biology, cardiology and cardiovascular medicine, cancer research, infectious diseases, and epidemiology. These emphases align with their topics of cancer metabolism, immune response during COVID-19, autophagy pathways, and cellular bioenergetics.

Best Publications

  • Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart

    Elisa Messina;Luciana De Angelis;Giacomo Frati;Stefania Morrone

  • Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer

    P. Gazzaniga;A. Gradilone;L. Giuliani;O. Gandini

  • Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

    Diana Bellavia;Antonio F. Campese;Edoardo Alesse;Alessandra Vacca

  • Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

    I Screpanti;L Romani;P Musiani;A Modesti

  • Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis

    Cristina Cerboni;Alessandra Zingoni;Marco Cippitelli;Mario Piccoli

  • Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

    Alessandra Vacca;Maria P. Felli;Antonietta R. Farina;Stefano Martinotti

  • Brain White-Matter Volume Loss and Glucose Hypometabolism Precede the Clinical Symptoms of Huntington's Disease

    Andrea Ciarmiello;Milena Cannella;Secondo Lastoria;Maria Simonelli

  • Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family.

    C. Marchese;J. Rubin;D. Ron;A. Faggioni

  • HE4: a new potential early biomarker for the recurrence of ovarian cancer

    Emanuela Anastasi;Giulia Giovanna Marchei;Valentina Viggiani;Giuseppina Gennarini

  • Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

    Diana Bellavia;Antonio F. Campese;Saula Checquolo;Anna Balestri

  • Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

    Maria Pia Felli;Marella Maroder;Thimios A. Mitsiadis;Antonio F. Campese

  • Human MRE11 is inactivated in mismatch repair‐deficient cancers

    Giuseppe Giannini;Elisabetta Ristori;Fabio Cerignoli;Christian Rinaldi

  • Involvement of p21ras activation in T cell CD69 expression.

    Daniele d'Ambrosio;Doreen A. Cantrell;Luigi Frati;Angela Santoni

  • Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia

    Alessandra Vacca;Maria Pia Felli;Rocco Palermo;Giuseppina Di Mario

  • Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients.

    A. Ciammola;J. Sassone;M. Cannella;S. Calza

  • Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory.

    Paolo Calabresi;Maddalena Napolitano;Diego Centonze;Girolama A. Marfia

  • The interaction between exogenous DNA and sperm cells.

    M. Lavitrano;D. French;M. Zani;L. Frati

  • Survivin, bcl-2, bax, and bcl-X Gene Expression in Sentinel Lymph Nodes From Melanoma Patients

    Angela Gradilone;Paola Gazzaniga;Diego Ribuffo;Susanna Scarpa

  • Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea.

    L. Frati;S. Daniele;A. Delogu;I. Covelli

  • Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

    Emanuela Anastasi;Antonio F. Campese;Diana Bellavia;Angela Bulotta

Frequent Co-Authors

Alberto Gulino
Alberto Gulino Sapienza University of Rome
Angela Santoni
Angela Santoni Sapienza University of Rome
Isabella Screpanti
Isabella Screpanti Sapienza University of Rome
Alberto Faggioni
Alberto Faggioni Sapienza University of Rome
Maria Rosaria Torrisi
Maria Rosaria Torrisi Sapienza University of Rome
Carlo Riccardi
Carlo Riccardi University of Perugia
Pierluigi Benedetti Panici
Pierluigi Benedetti Panici Sapienza University of Rome
Andrea Modesti
Andrea Modesti University of Rome Tor Vergata
Giovanni Scambia
Giovanni Scambia Catholic University of the Sacred Heart
Enzo Bonmassar
Enzo Bonmassar University of Rome Tor Vergata

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