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Biology and Biochemistry

D-Index
71
Citations
24738
World Ranking
6529
National Ranking
3040

Overview

Yu Yamaguchi is affiliated with the Discovery Institute in the United States and conducts research primarily in the fields of biochemistry, genetics, and molecular biology, as well as medicine. Their research output includes a focus on molecular biology, cell biology, genetics, physiology, and immunology and allergy. The scientist's investigations center on topics such as proteoglycans and glycosaminoglycans research, cellular transport and secretion, connective tissue disorders research, bone metabolism and diseases, fibroblast growth factor research, cell adhesion molecules research, and erythrocyte function and pathophysiology.

Their recent publications feature work published mainly in respected scientific journals, highlighting research topics related to molecular and cellular biology. Notable papers include:

  • "The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites" (2021, Journal of Biological Chemistry)
  • "The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover" (2021, Journal of Biological Chemistry)
  • "Update of the genotype and phenotype of KMT2D and KDM6A by genetic screening of 100 patients with clinically suspected Kabuki syndrome" (2020, American Journal of Medical Genetics Part A)
  • "The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors" (2021, Matrix Biology)
  • "The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis" (2020, Cellular and Molecular Immunology)

Yu Yamaguchi collaborates frequently with several coauthors including Takayuki Tsukuba, Tomoko Kadowaki, Eiko Sakai, Kenjiro Kosaki, and Kuniaki Okamoto. These partnerships point to a collaborative research style across multiple projects.

The scientist has published prolifically in certain venues, notably the Journal of Biological Chemistry, International Journal of Molecular Sciences, Scientific Reports, Congenital Anomalies, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

    Hong Gang Wang;Nuzhat Pathan;Iryna M. Ethell;Stanislaw Krajewski

  • DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

    Satomi Kuramochi-Miyagawa;Toshiaki Watanabe;Kengo Gotoh;Yasushi Totoki

  • Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling.

    Keith K. Murai;Louis N. Nguyen;Fumitoshi Irie;Yu Yamaguchi

  • NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors

    Leonard L. Jones;Yu Yamaguchi;William B. Stallcup;Mark H. Tuszynski;Mark H. Tuszynski

  • Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

    Masaru Inatani;Fumitoshi Irie;Andrew S. Plump;Marc Tessier-Lavigne

  • Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.

    David B. Kantor;Onanong Chivatakarn;Katherine L. Peer;Stephen F. Oster

  • Overproduction of Hyaluronan by Expression of the Hyaluronan Synthase Has2 Enhances Anchorage-independent Growth and Tumorigenicity

    Rika Kosaki;Ken Watanabe;Yu Yamaguchi

  • EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP

    Fumitoshi Irie;Yu Yamaguchi

  • The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.

    Anders Aspberg;Ryu Miura;Sandrine Bourdoulous;Motoyuki Shimonaka

  • EphB/syndecan-2 signaling in dendritic spine morphogenesis.

    Iryna M. Ethell;Fumitoshi Irie;Matthew S. Kalo;John R. Couchman

  • Cell surface glypicans are low-affinity endostatin receptors

    S. Ananth Karumanchi;Vivekanand Jha;Ramani Ramchandran;Anil Karihaloo;Anil Karihaloo

  • Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family.

    Hidekazu Yamada;Ken Watanabe;Motoyuki Shimonaka;Yu Yamaguchi

  • Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.

    Peter Milev;Patrice Maurel;Atsuro Chiba;Markus Mevissen

  • Molecular identification of a putative human hyaluronan synthase

    Ken Watanabe;Yu Yamaguchi

  • The Brain Chondroitin Sulfate Proteoglycan Brevican Associates with Astrocytes Ensheathing Cerebellar Glomeruli and Inhibits Neurite Outgrowth from Granule Neurons

    Hidekazu Yamada;Barbara Fredette;Kenya Shitara;Kazuki Hagihara

  • Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons.

    Iryna M. Ethell;Yu Yamaguchi

  • Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.

    Hiroyuki Nakamura;Yutaka Fujii;Isao Inoki;Kotaro Sugimoto

  • Eph receptors in the adult brain.

    Yu Yamaguchi;Elena B Pasquale

  • Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function

    Kay Grobe;Kay Grobe;Masaru Inatani;Srinivas R. Pallerla;Jan Castagnola

  • N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth.

    Geetha Srikrishna;Henri J. Huttunen;Lena Johansson;Bernd Weigle

Frequent Co-Authors

Erkki Ruoslahti
Erkki Ruoslahti Sanford Burnham Prebys Medical Discovery Institute
Maurizio Pacifici
Maurizio Pacifici Children's Hospital of Philadelphia
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Elena B. Pasquale
Elena B. Pasquale Discovery Institute
William B. Stallcup
William B. Stallcup Discovery Institute
Iryna M. Ethell
Iryna M. Ethell University of California, Riverside
Motomi Enomoto-Iwamoto
Motomi Enomoto-Iwamoto University of Maryland, Baltimore
Masahiro Iwamoto
Masahiro Iwamoto University of Maryland, Baltimore
Marc Tessier-Lavigne
Marc Tessier-Lavigne Xaira Therapeutics
Hudson H. Freeze
Hudson H. Freeze Discovery Institute

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