Brian E. Leonard

Research.com Recognitions

• 1983 - Member of the Royal Irish Academy

Overview

Best Publications

• The olfactory bulbectomised rat as a model of depression

  Cai Song;Brian E. Leonard

  921
  Citations

• The olfactory bulbectomized rat as a model of depression: An update

  J.P. Kelly;A.S. Wrynn;B.E. Leonard

  912
  Citations

• The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.

  M. Maes;B.E. Leonard;A.M. Myint;M. Kubera

  874
  Citations

• Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression.

  Brian Leonard;Michael Maes

  742
  Citations

• Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

  Michael Maes;Michael Berk;Lisa Goehler;Cai Song

  725
  Citations

• The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression.

  Yong Ku Kim;Kyoung Sae Na;Aye Mu Myint;Brian E. Leonard

  679
  Citations

• Depression, stress and immunological activation: the role of cytokines in depressive disorders.

  Thomas J. Connor;Brian E. Leonard

  658
  Citations

• Th1, Th2, and Th3 cytokine alterations in major depression.

  Aye Mu Myint;Brian E. Leonard;Harry W.M. Steinbusch;Yong Ku Kim

  483
  Citations

• The immune system, depression and the action of antidepressants.

  Brian E. Leonard

  453
  Citations

• Inflammation, depression and dementia: are they connected?

  Brian E. Leonard;Brian E. Leonard

  441
  Citations

• Association of high-sensitivity C-reactive protein with de novo major depression

  Julie A. Pasco;Geoffrey C. Nicholson;Lana J. Williams;Felice N. Jacka

  385
  Citations

• A review of the role of serotonin receptors in psychiatric disorders.

  Marie Naughton;Jane B. Mulrooney;Brian E. Leonard

  353
  Citations

• The Concept of Depression as a Dysfunction of the Immune System

  Brian E. Leonard

  319
  Citations

• Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats.

  H. van Riezen;B.E. Leonard

  313
  Citations

• Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.

  Brian E. Leonard;Denise McCartan;John White;David J. King

  305
  Citations

• An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat

  T.J Connor;C Song;B.E Leonard;Z Merali

  283
  Citations

• The role of noradrenaline and selective noradrenaline reuptake inhibition in depression

  Nicoletta Brunello;Julien Mendlewicz;Siegfried Kasper;Brian Leonard

  281
  Citations

• The psychoneuroimmunology of depression.

  Brian E. Leonard;Brian E. Leonard;Ayemu Myint

  280
  Citations

• HPA and immune axes in stress: involvement of the serotonergic system.

  Brian E. Leonard

  173
  Citations

• Research report Kynurenine pathway in major depression: Evidence of impaired neuroprotection

  Aye-Mu Myint;Yong Ku Kim;Robert Verkerk;Simon Scharpé

  0
  Citations