Andrew Harkin

Best Publications

• The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes.

  Wouter Beumer;Sinead M. Gibney;Roosmarijn C. Drexhage;Lorena Pont-Lezica

  412
  Citations

• Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test.

  Andrew J Harkin;Karen H Bruce;Brandy Craft;Ian A Paul

  275
  Citations

• Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

  Thomas J. Connor;Neasa Starr;Joan B. O'Sullivan;Andrew Harkin

  245
  Citations

• Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression.

  Sinead M. Gibney;Barry McGuinness;Christine Prendergast;Andrew Harkin

  234
  Citations

• Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.

  Valentina Gigliucci;Grainne O’Dowd;Sheena Casey;Danielle Egan

  211
  Citations

• Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease.

  Áine Abautret-Daly;Elaine Dempsey;Adolfo Parra-Blanco;Carlos Medina

  188
  Citations

• DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse

  Chloё Farrell;Kelly Doolin;Niamh O’ Leary;Chaitra Jairaj

  167
  Citations

• Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors

  A Harkin;T.J Connor;M Walsh;N St John

  162
  Citations

• Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders

  Katherine O'Farrell;Andrew Harkin

  162
  Citations

• Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration.

  Joan B. O'Sullivan;Karen M. Ryan;Niamh M. Curtin;Andrew Harkin

  159
  Citations

• Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression

  Andrew Harkin;John P Kelly;Mairead McNamara;Thomas J Connor

  134
  Citations

• Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test.

  Thomas J. Connor;Padraig Kelliher;Yan Shen;Andrew Harkin

  134
  Citations

• Acute stress suppresses pro-inflammatory cytokines TNF-α and IL-1β independent of a catecholamine-driven increase in IL-10 production

  Thomas J. Connor;Charlene Brewer;John P. Kelly;Andrew Harkin

  125
  Citations

• A review of the relevance and validity of olfactory bulbectomy as a model of depression

  Andrew Harkin;John P Kelly;Brian E Leonard

  123
  Citations

• Varying responses to the rat forced-swim test under diurnal and nocturnal conditions

  Padraig Kelliher;Thomas J Connor;Andrew Harkin;Connie Sanchez

  121
  Citations

• Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation

  Martina M. Hughes;Angela Carballedo;Declan M. McLoughlin;Francesco Amico

  119
  Citations

• Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour.

  Sinead M Gibney;Eimear M Fagan;Ann-Marie Waldron;Jordan O'Byrne

  118
  Citations

• Olfactory bulbectomy in mice induces alterations in exploratory behavior.

  M. Zueger;A. Urani;S. Chourbaji;C. Zacher

  116
  Citations

• C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.

  Maria M. Pertl;David Hevey;Noreen T. Boyle;Martina M. Hughes

  115
  Citations

• Olfactory Bulbectomy Provokes a Suppression of Interleukin-1β and Tumour Necrosis Factor-α Production in Response to an in vivo Challenge with Lipopolysaccharide: Effect of Chronic Desipramine Treatment

  Thomas J. Connor;Andrew Harkin;John P. Kelly;Brian E. Leonard

  113
  Citations