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Neuroscience

D-Index
39
Citations
6629
World Ranking
8301
National Ranking
31

Overview

John J. O'Connor is affiliated with University College Dublin in Ireland. Their research spans multiple fields within medicine, with a focus on neurology, molecular biology, cancer research, biochemistry, and clinical psychology.

The scientist's main topics of work include:

  • Cancer, Hypoxia, and Metabolism
  • Neurological Disease Mechanisms and Treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Biochemical effects in animals
  • Vaccine Coverage and Hesitancy
  • Advanced X-ray and CT Imaging

Frequent co-authors in their research collaborations include Wiremu Woodard, Martina Puzio, Niamh Moreton, Marco Boeri, and Christine Poulos.

John J. O'Connor has published extensively in various scientific venues. The most frequent publication sources are:

  • Ata Journal of Psychotherapy Aotearoa New Zealand
  • Brain Research Bulletin
  • Brain Disorders
  • Transfusion and Apheresis Science
  • Antioxidants

Significant recent papers authored or co-authored by O'Connor include:

  • Neuroprotective strategies for acute ischemic stroke: Targeting oxidative stress and prolyl hydroxylase domain inhibition in synaptic signalling, 2022, Brain Disorders
  • Cold stored platelets - Increasing understanding and acceptance, 2023, Transfusion and Apheresis Science
  • An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices, 2023, Antioxidants
  • The effects of prolyl hydroxylase inhibition during and post, hypoxia, oxygen glucose deprivation and oxidative stress, in isolated rat hippocampal slices, 2023, Brain Research Bulletin
  • The effects of the superoxide dismutase mimetic, MnTMPyP, post hypoxia and oxygen glucose deprivation in isolated rat hippocampal slices, 2022, Brain Research Bulletin

The scientist's work integrates biochemical and physiological processes related to oxidative stress, ischemia, hypoxia, and neuroprotection, often using animal models such as isolated rat hippocampal slices. Their cross-disciplinary focus includes neuroinflammation and mechanisms underlying neurological diseases, alongside studies on cancer metabolism and vaccine-related topics.

Best Publications

  • Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

    A.J. Cunningham;C.A. Murray;L.A.J. O'Neill;M.A. Lynch

  • Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system

    Mark Pickering;Derval Cumiskey;John J. O'Connor

  • Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

    Fengmin Lu;Mary Selak;John O’Connor;Sidney Croul

  • Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients

    Kumar Sharma;Kumar Sharma;Robert V. Considine;Robert V. Considine;Beckie Michael;Beckie Michael;Stephen R. Dunn;Stephen R. Dunn

  • Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP.

    Marion P. Butler;J.J. O'Connor;Paul N. Moynagh

  • Pro-inflammatory cytokines and their effects in the dentate gyrus.

    Mark Pickering;John J O'Connor

  • Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation.

    John J. O'Connor;Michael J. Rowan;Roger Anwyl

  • Oxidative damage to DNA in plaques of MS brains.

    Olga Vladimirova;John O'Connor;Alan Cahill;Hansjuerg Alder

  • P42/44 MAP kinase inhibitor PD98059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro

    Andrew N. Coogan;Deirdre M. O'Leary;John J. O'Connor

  • The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS

    Gatambwa Mukandala;Ronan Tynan;Sinead Lanigan;John J. O’Connor

  • Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: investigations of the involvement of mGlu receptors

    JJ O'Connor;MJ Rowan;R Anwyl

  • The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro.

    B Curran;J.J O’Connor

  • The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro

    A.N. Coogan;L.A.J. O'Neill;J.J. O'Connor

  • A role for c-jun n-terminal kinase in the inhibition of long-term potentiation by interleukin-1β and long-term depression in the rat dentate gyrus in vitro

    B.P Curran;H.J Murray;J.J O’Connor

  • Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy.

    Yolanda Alvarez;Kenneth Chen;Alison L. Reynolds;Nora Waghorne

  • Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1β

    Coogan A;O'Connor Jj

  • A role for tumor necrosis factor-α in ischemia and ischemic preconditioning.

    Orla Watters;John J O'Connor

  • Actions of the pro-inflammatory cytokine IL-1 beta on central synaptic transmission.

    John J. O'Connor;Andrew N. Coogan

  • Large scale screening of the mitochondrial DNA reveals no pathogenic mutations but a haplotype associated with multiple sclerosis in Caucasians

    B. Kalman;S. Li;D. Chatterjee;D. Chatterjee;J. O'Connor;J. O'Connor

  • CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

    Graham K. Sheridan;Graham K. Sheridan;Anita Wdowicz;Mark Pickering;Orla Watters

  • Fast cyclic voltammetry can be used to measure stimulated endogenous 5-hydroxytryptamine release in untreated rat brain slices.

    J.J. O'Connor;Z.L. Kruk

Frequent Co-Authors

Roger Anwyl
Roger Anwyl Trinity College Dublin
Michael J. Rowan
Michael J. Rowan Trinity College Dublin
Zygmunt L. Kruk
Zygmunt L. Kruk University of Portsmouth
Andrew N. Coogan
Andrew N. Coogan National University of Ireland, Maynooth
Rose Anne Kenny
Rose Anne Kenny Trinity College Dublin
Michael Fitzgerald
Michael Fitzgerald Trinity College Dublin
John E. Moore
John E. Moore Belfast City Hospital
John L. Waddington
John L. Waddington Royal College of Surgeons in Ireland

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