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Jacques Simard

Jacques Simard

D-Index & Metrics

Medicine

D-Index
111
Citations
52507
World Ranking
5287
National Ranking
208

Overview

Jacques Simard is affiliated with Université Laval in Canada. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a particular focus on genetics and oncology. The scientist's work encompasses a range of subfields including molecular biology, cancer research, and pathology and forensic medicine.

The main topics covered in their research include BRCA gene mutations in cancer, global cancer incidence and screening, genetic associations and epidemiology, nutrition, genetics, and disease, cancer genomics and diagnostics, cancer risks and factors, and colorectal cancer screening and detection.

Simard has published in various academic venues, frequently contributing to Journal of Personalized Medicine, Cancers, bioRxiv (Cold Spring Harbor Laboratory), Apollo (University of Cambridge), and Genetics in Medicine.

Among recent published papers are the following:

  • Personalized early detection and prevention of breast cancer: ENVISION consensus statement, 2020, Nature Reviews Clinical Oncology
  • European polygenic risk score for prediction of breast cancer shows similar performance in Asian women, 2020, Nature Communications
  • Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I), 2021, Journal of Personalized Medicine
  • Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers, 2020, Nature Communications
  • Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study, 2022, Journal of Medical Genetics

Frequent co-authors collaborating with Simard include Douglas F. Easton, Antonis C. Antoniou, Joe Dennis, Paul D.P. Pharoah, and Marjanka K. Schmidt. These collaborations reflect ongoing engagement with researchers involved in cancer genetics and risk prediction.

Best Publications

  • Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

    Karoline B. Kuchenbaecker;Karoline B. Kuchenbaecker;John L. Hopper;Daniel R. Barnes;Kelly-Anne Phillips

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.

    S.V. Tavtigian;J. Simard;J. Rommens;F. Couch

  • RAD51B in Familial Breast Cancer

    Liisa M. Pelttari;Sofia Khan;Mikko Vuorela;Johanna I. Kiiski

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

    Leila Dorling;Sara Carvalho;Jamie Allen

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • A candidate prostate cancer susceptibility gene at chromosome 17p.

    Sean V. Tavtigian;Jacques Simard;David H F Teng;Vicki Abtin

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • Molecular Biology of the 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Gene Family

    Jacques Simard;Marie-Louise Ricketts;Sébastien Gingras;Penny Soucy

  • MicroRNA related polymorphisms and breast cancer risk

    Sofia Khan;Dario Greco;Dario Greco;Kyriaki Michailidou;Roger L. Milne;Roger L. Milne

  • Is dehydroepiandrosterone a hormone

    F Labrie;V Luu-The;A Bélanger;S-X Lin

  • A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening

    Donna Shattuck Eidens;Melody Mcclure;Jacques Simard;Fernand Labrie

  • BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.

    Andrew Lee;Nasim Mavaddat;Amber N Wilcox;Alex P Cunningham

  • Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

    Fernand Labrie;Van Luu-The;Claude Labrie;Alain Bélanger

  • The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

    Fernand Labrie;Van Luu-The;Sheng-Xiang Lin;Labrie Claude

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

Frequent Co-Authors

Roger L. Milne
Roger L. Milne Cancer Council Victoria
Douglas F. Easton
Douglas F. Easton University of Cambridge
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Graham G. Giles
Graham G. Giles University of Melbourne
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Melissa C. Southey
Melissa C. Southey Monash University
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Anna Jakubowska
Anna Jakubowska Pomeranian Medical University
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center

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