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Microbiology

D-Index
51
Citations
10948
World Ranking
4299
National Ranking
1659

Research.com Recognitions

  • 1968 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William B. Klimstra is affiliated with the University of Pittsburgh in the United States and specializes primarily in the field of Medicine, with a focus on Infectious Diseases, Public Health, Environmental and Occupational Health, Epidemiology, Animal Science and Zoology, and Genetics.

The scientist's research topics encompass areas such as:

  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • SARS-CoV-2 and COVID-19 Research
  • Viral Infections and Outbreaks Research
  • Virology and Viral Diseases
  • Animal Virus Infections Studies
  • COVID-19 Clinical Research Studies

Klimstra has contributed to several recent scientific papers, including:

  • "Animal models for COVID-19," published in 2020 in Nature
  • "Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development," published in 2020 in EBioMedicine
  • "Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions," published in 2020 in Emerging infectious diseases
  • "Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions," published in 2020 in bioRxiv (Cold Spring Harbor Laboratory)
  • "Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses," published in 2021 in Science Advances

Frequent collaborators in Klimstra's research include:

  • Douglas S. Reed
  • Theron Gilliland
  • Amy L. Hartman
  • Matthew D. Dunn
  • Chengqun Sun

The scientist's work has appeared in several prominent publication venues, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • UNC Libraries
  • PLoS Pathogens
  • Nature Communications

Klimstra has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 1968.

Best Publications

  • 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

    Stephane Daffis;Kristy J. Szretter;Jill Schriewer;Jianqing Li

  • Animal models for COVID-19.

    César Muñoz-Fontela;William E. Dowling;Simon G.P. Funnell;Pierre S. Gsell

  • Adaptation of Sindbis Virus to BHK Cells Selects for Use of Heparan Sulfate as an Attachment Receptor

    William B. Klimstra;Kate D. Ryman;Robert E. Johnston

  • MicroRNA Regulation of RNA Virus Replication and Pathogenesis.

    Derek W. Trobaugh;William B. Klimstra

  • Mxra8 is a receptor for multiple arthritogenic alphaviruses

    Rong Zhang;Arthur S. Kim;Julie M. Fox;Sharmila Nair

  • Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.

    Eun Kim;Geza Erdos;Shaohua Huang;Thomas W. Kenniston

  • Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions.

    Alyssa C. Fears;William B. Klimstra;Paul Duprex;Amy Hartman

  • Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism.

    Kate D. Ryman;William B. Klimstra;Khuong B. Nguyen;Christine A. Biron

  • Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice.

    Kristen A. Bernard;William B. Klimstra;Robert E. Johnston

  • RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

    Derek W. Trobaugh;Christina L. Gardner;Chengqun Sun;Andrew D. Haddow

  • DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses

    Unknown

  • A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

    Jennifer L. Hyde;Christina L. Gardner;Taishi Kimura;James P. White

  • Host responses to alphavirus infection

    Unknown

  • A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

    Unknown

  • Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions

    Alyssa C. Fears;Robert F. Garry;Chad J. Roy;Douglas S. Reed

  • Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

    Sham Nambulli;Yufei Xiang;Natasha L. Tilston-Lunel;Linda J. Rennick

  • SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients.

    William B. Klimstra;Natasha L. Tilston-Lunel;Sham Nambulli;James Boslett

  • Mosquito Saliva Serine Protease Enhances Dissemination of Dengue Virus into the Mammalian Host

    Michael J. Conway;Alan M. Watson;Tonya M. Colpitts;Srdjan M. Dragovic;Srdjan M. Dragovic

  • Stable, High-Level Expression of Reporter Proteins from Improved Alphavirus Expression Vectors To Track Replication and Dissemination during Encephalitic and Arthritogenic Disease

    Unknown

  • SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts.

    Amy L. Hartman;Sham Nambulli;Cynthia M. McMillen;Alexander G. White

  • Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.

    Christina L. Gardner;Crystal W. Burke;Stephen T. Higgs;William B. Klimstra;William B. Klimstra

  • Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence

    Christina L. Gardner;Gregory D. Ebel;Kate D. Ryman;William B. Klimstra

  • Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion

    Angel M Paredes;Davis Ferreira;Michelle Horton;Ali Saad

  • Adaptation of alphaviruses to heparan sulfate: Interaction of Sindbis and Semliki Forest viruses with liposomes containing lipid-conjugated heparin

    Jolanda M. Smit;Barry-Lee Waarts;Koji Kimata;William B. Klimstra

  • Sindbis Virus Translation Is Inhibited by a PKR/RNase L-Independent Effector Induced by Alpha/Beta Interferon Priming of Dendritic Cells

    K. D. Ryman;K. C. Meier;E. M. Nangle;S. L. Ragsdale

  • Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome.

    W. B. Klimstra;K. D. Ryman;K. A. Bernard;K. B. Nguyen

  • DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses

    Unknown

Frequent Co-Authors

Michael S. Diamond
Michael S. Diamond Washington University in St. Louis
James E. Crowe
James E. Crowe Vanderbilt University Medical Center
W. Paul Duprex
W. Paul Duprex University of Pittsburgh
Daved H. Fremont
Daved H. Fremont Washington University in St. Louis
Scott C. Weaver
Scott C. Weaver The University of Texas Medical Branch at Galveston
JoAnne L. Flynn
JoAnne L. Flynn University of Pittsburgh
Michael G. Rossmann
Michael G. Rossmann Purdue University West Lafayette
Benjamin J. Doranz
Benjamin J. Doranz University of Pennsylvania
Chad J. Roy
Chad J. Roy Tulane University

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