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Microbiology

D-Index
63
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11035
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2804
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Overview

Ilya Frolov is a researcher affiliated with the University of Alabama at Birmingham in the United States. Their work spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Infectious Diseases, Public Health, Environmental and Occupational Health, Molecular Biology, Virology, and Immunology.

Their research topics include:

  • Mosquito-borne diseases and control
  • SARS-CoV-2 and COVID-19 Research
  • HIV Research and Treatment
  • Viral Infections and Vectors
  • COVID-19 Clinical Research Studies
  • Interferon and immune responses
  • Virus-based gene therapy research

Frolov has published research in several venues, with the majority appearing in the Journal of Virology. Other publication venues include bioRxiv (Cold Spring Harbor Laboratory), Emerging Microbes & Infections, and PLoS ONE.

The most recent papers authored or co-authored by Frolov capture a range of topics related to viral mechanisms, infectivity, and immunogenicity:

  • Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage (2021, Journal of Virology)
  • Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein (2020, Journal of Virology)
  • Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence (2020, Journal of Virology)
  • Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling (2022, Journal of Virology)
  • Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models (2021, Emerging Microbes & Infections)

Frequent co-authors collaborating with Frolov include:

  • Elena I. Frolova
  • Francisco Domínguez
  • Oksana Palchevska
  • Nikita Shiliaev
  • Tetyana Lukash

Best Publications

  • Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.

    P J Bredenbeek;I Frolov;C M Rice;S Schlesinger

  • ALPHAVIRUS-BASED EXPRESSION VECTORS : STRATEGIES AND APPLICATIONS

    Ilya Frolov;Thomas A. Hoffman;Bela M. Pragai;Sergey A. Dryga

  • The Old World and New World Alphaviruses Use Different Virus-Specific Proteins for Induction of Transcriptional Shutoff

    Natalia Garmashova;Rodion Gorchakov;Eugenia Volkova;Slobodan Paessler

  • Noncytopathic Sindbis virus RNA vectors for heterologous gene expression

    Eugene V. Agapov;Ilya Frolov;Brett D. Lindenbach;Béla M. Prágai

  • Roles of Nonstructural Protein nsP2 and Alpha/Beta Interferons in Determining the Outcome of Sindbis Virus Infection

    Elena I. Frolova;Rafik Z. Fayzulin;Susan H. Cook;Diane E. Griffin

  • CHIMERIC ALPHAVIRUS VACCINE CANDIDATES FOR CHIKUNGUNYA

    Eryu Wang;Eugenia Volkova;A. Paige Adams;Naomi Forrester

  • Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription.

    Natalia Garmashova;Rodion Gorchakov;Elena Frolova;Ilya Frolov

  • Selection of RNA Replicons Capable of Persistent Noncytopathic Replication in Mammalian Cells

    Ilya Frolov;Eugene Agapov;Thomas A. Hoffman;Béla M. Prágai

  • Functional Sindbis virus replicative complexes are formed at the plasma membrane.

    Elena I. Frolova;Rodion Gorchakov;Larisa Pereboeva;Svetlana Atasheva

  • Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism

    Kenneth Plante;Eryu Wang;Charalambos D. Partidos;James Weger

  • Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.

    Ilya Frolov;Richard Hardy;Charles M. Rice

  • New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes

    Dal Young Kim;Josephine M. Reynaud;Aliaksandra Rasalouskaya;Ivan Akhrymuk

  • Stable alphavirus packaging cell lines for Sindbis virus- and Semliki Forest virus-derived vectors

    John M. Polo;Barbara A. Belli;David A. Driver;Ilya Frolov

  • Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells

    Rodion Gorchakov;Elena I. Frolova;Ilya Frolov

  • Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

    Svetlana Atasheva;Elena I. Frolova;Ilya Frolov

  • Formation of nsP3-Specific Protein Complexes during Sindbis Virus Replication

    Elena Frolova;Rodion Gorchakov;Natalia Garmashova;Svetlana Atasheva

  • Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells.

    I Frolov;S Schlesinger

  • Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein Function in the Inhibition of Cellular Transcription

    Natalia Garmashova;Svetlana Atasheva;Wenli Kang;Scott C. Weaver

  • Noncytopathic Replication of Venezuelan Equine Encephalitis Virus and Eastern Equine Encephalitis Virus Replicons in Mammalian Cells

    Olga Petrakova;Eugenia Volkova;Rodion Gorchakov;Slobodan Paessler

  • Packaging signals in alphaviruses.

    E Frolova;I Frolov;S Schlesinger

  • Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

    Jason P. Gardner;Ilya Frolov;Silvia Perri;Yaying Ji

  • A chikungunya fever vaccine utilizing an insect-specific virus platform

    Jesse H Erasmus;Albert J Auguste;Jason T Kaelber;Huanle Luo

Frequent Co-Authors

Elena I. Frolova
Elena I. Frolova University of Alabama at Birmingham
Scott C. Weaver
Scott C. Weaver The University of Texas Medical Branch at Galveston
Charles M. Rice
Charles M. Rice Rockefeller University
Sondra Schlesinger
Sondra Schlesinger Washington University in St. Louis
Slobodan Paessler
Slobodan Paessler The University of Texas Medical Branch at Galveston
Peter W. Mason
Peter W. Mason Novartis (Switzerland)
Ann M. Powers
Ann M. Powers Centers for Disease Control and Prevention
Brett D. Lindenbach
Brett D. Lindenbach Yale University
Thomas W. Dubensky
Thomas W. Dubensky Tempest Therapeutics
David W.C. Beasley
David W.C. Beasley The University of Texas Medical Branch at Galveston

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