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Thorsten Mielke

Thorsten Mielke

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9528
World Ranking
16224
National Ranking
1138

Overview

Thorsten Mielke is affiliated with the Max Planck Society in Germany and has an active research profile primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Genetics, Cell Biology, Materials Chemistry, and Ecology.

The main topics of Thorsten Mielke's research encompass:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Bacteriophages and microbial interactions
  • Genomics and Phylogenetic Studies
  • Enzyme Structure and Function
  • Cytomegalovirus and herpesvirus research

They have published extensively, with notable recent papers including:

  • "Dnmt1 has de novo activity targeted to transposable elements," 2021, Nature Structural & Molecular Biology
  • "Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ," 2020, Science
  • "Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide," 2021, Cell Research
  • "Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase," 2020, Nature Communications
  • "Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates," 2022, The EMBO Journal

Frequently publishing in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Structural & Molecular Biology
  • Molecular Cell
  • iScience

Thorsten Mielke collaborates regularly with several coauthors, including:

  • Jörg Bürger
  • C.M.T. Spahn
  • Beatrix Fauler
  • Matthias Selbach
  • David Meierhofer

Their research integrates molecular techniques and structural biology approaches to address complex biological processes such as enzyme function, RNA dynamics, and cellular interactions with microbial agents. Their work contributes to various areas in molecular and cellular biology, emphasizing mechanisms underlying RNA behavior and protein interactions within cellular contexts.

Best Publications

  • Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

    Andreas H. Ratje;Andreas H. Ratje;Justus Loerke;Aleksandra Mikolajka;Matthias Brünner

  • Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

    Thomas Becker;Shashi Bhushan;Alexander Jarasch;Jean Paul Armache

  • Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

    Jens Frauenfeld;James Gumbart;Eli O van der Sluis;Eli O van der Sluis;Soledad Funes

  • Electron crystallography reveals the structure of metarhodopsin I.

    Jonathan J Ruprecht;Thorsten Mielke;Reiner Vogel;Claudio Villa

  • Structural insight into nascent polypeptide chain-mediated translational stalling.

    Birgit Seidelt;C. Axel Innis;Daniel N. Wilson;Marco Gartmann

  • Functional architecture of RNA polymerase I.

    Claus-D. Kuhn;Sebastian R. Geiger;Sonja Baumli;Marco Gartmann

  • Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

    Jean Paul Armache;Alexander Jarasch;Andreas M. Anger;Elizabeth Villa

  • [alpha]-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

    Shashi Bhushan;Marco Gartmann;Mario Halic;Mario Halic;Jean Paul Armache

  • Following the signal sequence from ribosomal tunnel exit to signal recognition particle.

    Mario Halic;Michael Blau;Thomas Becker;Thorsten Mielke

  • Structure of the ribosome-bound cricket paralysis virus IRES RNA

    Martin Schüler;Sean R Connell;Aurelie Lescoute;Jan Giesebrecht

  • GTPase activation of elongation factor EF-Tu by the ribosome during decoding

    Jan-Christian Jan-Christian Schuette;Frank V. Murphy;Ann C. Kelley;John R. Weir

  • Coupled chaperone action in folding and assembly of hexadecameric Rubisco

    Cuimin Liu;Anna L. Young;Amanda Starling-Windhof;Andreas Bracher

  • Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.

    Sean R. Connell;Chie Takemoto;Daniel N. Wilson;Hongfei Wang

  • Structure of eEF3 and the Mechanism of Transfer RNA Release From the E-Site

    Christian B. F. Andersen;Thomas Becker;Thomas Becker;Michael Blau;Monika Anand

  • Structural Snapshots of Actively Translating Human Ribosomes

    Elmar Behrmann;Justus Loerke;Tatyana V. Budkevich;Kaori Yamamoto

  • SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center

    Shashi Bhushan;Thomas Hoffmann;Birgit Seidelt;Jens Frauenfeld

  • Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.

    Thomas Becker;Jean Paul Armache;Alexander Jarasch;Andreas M. Anger

  • Signal Recognition Particle Receptor Exposes the Ribosomal Translocon Binding Site

    Mario Halic;Marco Gartmann;Oliver Schlenker;Thorsten Mielke

  • Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation

    David J. F. Ramrath;Laura Lancaster;Thiemo Sprink;Thorsten Mielke;Thorsten Mielke

  • Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome.

    Jean Paul Armache;Alexander Jarasch;Andreas M. Anger;Elizabeth Villa

Frequent Co-Authors

Christian M. T. Spahn
Christian M. T. Spahn Charité - University Medicine Berlin
Roland Beckmann
Roland Beckmann Ludwig-Maximilians-Universität München
Otto Berninghausen
Otto Berninghausen Ludwig-Maximilians-Universität München
Thomas S. Becker
Thomas S. Becker University of Sydney
Markus C. Wahl
Markus C. Wahl Freie Universität Berlin
Daniel N. Wilson
Daniel N. Wilson Universität Hamburg
Knud H. Nierhaus
Knud H. Nierhaus Max Planck Society
Stephan J. Sigrist
Stephan J. Sigrist Freie Universität Berlin
Matthias Selbach
Matthias Selbach Max Delbrück Center for Molecular Medicine
Klaus Schulten
Klaus Schulten University of Illinois at Urbana-Champaign

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