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Masahiro Ono

Masahiro Ono

D-Index & Metrics

Chemistry

D-Index
48
Citations
10173
World Ranking
15101
National Ranking
1182

Overview

Masahiro Ono is affiliated with Kyoto University in Japan and has contributed extensively to the field of medicine, with a particular focus on radiology, nuclear medicine, and imaging. Their research portfolio encompasses over 130 publications, highlighting significant engagement in related biomedical sciences.

The main fields of study for Masahiro Ono include:

  • Medicine

Within this broad discipline, the subfields of research addressed are:

  • Radiology, Nuclear Medicine and Imaging
  • Molecular Biology
  • Oncology
  • Physiology
  • Neurology

Masahiro Ono's scientific investigations frequently cover topics such as:

  • Radiopharmaceutical Chemistry and Applications
  • Alzheimer's disease research and treatments
  • Peptidase Inhibition and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Prostate Cancer Treatment and Research
  • Enzyme function and inhibition
  • Neuroscience and Neuropharmacology Research

The scientist has published in a range of specialized journals. Frequent publication venues include:

  • Nuclear Medicine and Biology
  • Bioorganic & Medicinal Chemistry Letters
  • ACS Medicinal Chemistry Letters
  • Journal of Medicinal Chemistry
  • ACS Chemical Neuroscience

Some of the recent research outputs by Masahiro Ono are:

  • Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging (2020), ACS Chemical Neuroscience
  • Radiotheranostics Using a Novel 225Ac-Labeled Radioligand with Improved Pharmacokinetics Targeting Prostate-Specific Membrane Antigen (2021), Journal of Medicinal Chemistry
  • Modulation of the Pharmacokinetics of a Radioligand Targeting Carbonic Anhydrase-IX with Albumin-Binding Moieties (2021), Molecular Pharmaceutics
  • First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas (2021), Frontiers in Endocrinology
  • Development of Novel 111In/225Ac-Labeled Agent Targeting PSMA for Highly Efficient Cancer Radiotheranostics (2023), Journal of Medicinal Chemistry

Collaboration is a notable aspect of their research activities. Frequent co-authors are:

  • Hiroyuki Watanabe
  • Shimpei Iikuni
  • Kazuma Nakashima
  • Yoichi Shimizu
  • Yuji Nakamoto

Best Publications

  • Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

    Shimon Sakaguchi;Masahiro Ono;Ruka Setoguchi;Haruhiko Yagi

  • Smart near-infrared fluorescence probes with donor-acceptor structure for in vivo detection of β-amyloid deposits.

    Mengchao Cui;Masahiro Ono;Hiroyuki Watanabe;Hiroyuki Kimura

  • 11C-labeled stilbene derivatives as Aβ-aggregate-specific PET imaging agents for Alzheimer’s disease

    Masahiro Ono;Alan Wilson;Jose Nobrega;David Westaway

  • BODIPY-based molecular probe for imaging of cerebral β-amyloid plaques.

    Masahiro Ono;Hiroyuki Watanabe;Hiroyuki Kimura;Hideo Saji

  • Benzofuran derivatives as Aβ-aggregate-specific imaging agents for Alzheimer’s disease

    Masahiro Ono;Mei-Ping Kung;Catherine Hou;Hank F. Kung

  • Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.

    Masahiro Ono;Hidekazu Kawashima;Akemi Nonaka;Tomoki Kawai

  • Development of a Novel 99mTc-Chelate–Conjugated Bisphosphonate with High Affinity for Bone as a Bone Scintigraphic Agent

    Kazuma Ogawa;Takahiro Mukai;Yasuyuki Inoue;Masahiro Ono

  • Reassessment of diethylenetriaminepentaacetic acid (DTPA) as a chelating agent for indium-111 labeling of polypeptides using a newly synthesized monoreactive DTPA derivative.

    Yasushi Arano;Takashi Uezono;Hiromichi Akizawa;Masahiro Ono

  • Effect of molecular charges on renal uptake of 111In-DTPA-conjugated peptides

    Hiromichi Akizawa;Yasushi Arano;Masaki Mifune;Akimasa Iwado

  • Novel 18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains

    Masahiro Ono;Yan Cheng;Hiroyuki Kimura;Mengchao Cui

  • Radioiodinated Flavones for in Vivo Imaging of β-Amyloid Plaques in the Brain

    Masahiro Ono;Naoko Yoshida;Kenichi Ishibashi;Mamoru Haratake

  • Novel chalcones as probes for in vivo imaging of β-amyloid plaques in Alzheimer’s brains

    Masahiro Ono;Mamoru Haratake;Hiroshi Mori;Morio Nakayama

  • Synthesis and Evaluation of Novel Chalcone Derivatives with 99mTc/Re Complexes as Potential Probes for Detection of β-Amyloid Plaques

    Masahiro Ono;Ryoichi Ikeoka;Hiroyuki Watanabe;Hiroyuki Kimura

  • Aurones serve as probes of β-amyloid plaques in Alzheimer’s disease

    Masahiro Ono;Yoshifumi Maya;Mamoru Haratake;Kazuhiro Ito

  • Development of a rhenium-186-labeled MAG3-conjugated bisphosphonate for the palliation of metastatic bone pain based on the concept of bifunctional radiopharmaceuticals.

    Kazuma Ogawa;Takahiro Mukai;Yasushi Arano;Masahiro Ono

  • Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

    Masahiro Ono;Shun Hayashi;Kenji Matsumura;Hiroyuki Kimura

  • Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for β-amyloid plaques.

    Mengchao Cui;Masahiro Ono;Hiroyuki Kimura;Boli Liu

  • Differences in transport mechanisms of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in inflammation, prostate cancer, and glioma cells: comparison with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose.

    Shuntaro Oka;Hiroyuki Okudaira;Masahiro Ono;David M. Schuster

  • Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer’s Brains

    Yan Cheng;Masahiro Ono;Hiroyuki Kimura;Masashi Ueda

  • Chemical Design of Radiolabeled Antibody Fragments for Low Renal Radioactivity Levels

    Yasushi Arano;Yasushi Fujioka;Hiromichi Akizawa;Masahiro Ono

Frequent Co-Authors

Hideo Saji
Hideo Saji Kyoto University
Masafumi Ihara
Masafumi Ihara Kyoto University
Kaori Togashi
Kaori Togashi Kyoto University
Nobuya Inagaki
Nobuya Inagaki Kyoto University
Ryosuke Takahashi
Ryosuke Takahashi Kyoto University
Junji Konishi
Junji Konishi Kyoto University
Hank F. Kung
Hank F. Kung University of Pennsylvania
Yoshiaki Kiso
Yoshiaki Kiso Nagahama Institute of Bio-Science and Technology
Masahiro Hiraoka
Masahiro Hiraoka Kyoto University
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo

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