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Neuroscience

D-Index
39
Citations
7079
World Ranking
8278
National Ranking
285

Overview

Hitoshi Shinotoh is affiliated with the National Institutes for Quantum and Radiological Science and Technology in Japan. Their research primarily focuses on topics within medicine, with notable contributions in physiology, neurology, psychiatry and mental health, radiology, nuclear medicine and imaging, and cognitive neuroscience.

The scientist's work covers a broad range of topics including:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Parkinson's Disease Mechanisms and Treatments
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Neurological disorders and treatments
  • Neuroscience and Neuropharmacology Research

Hitoshi Shinotoh has published extensively, with frequent appearances in these venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology
  • Alzheimer s & Dementia
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Neuron

Recent papers highlight the scientist's focus on neurodegenerative diseases and imaging techniques. Selected recent publications include:

  • High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies, 2020, Neuron
  • Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases, 2024, Neuron
  • High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy, 2022, Movement Disorders
  • A Machine Learning-Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images, 2022, Movement Disorders
  • Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease, 2023, Annals of Neurology

Frequent coauthors collaborating with Shinotoh include:

  • Kenji Tagai
  • Keisuke Takahata
  • Hitoshi Shimada
  • Yuhei Takado
  • Kiwamu Matsuoka

The research encompasses a multidisciplinary approach combining neuroimaging and machine learning techniques to investigate protein pathologies such as tau and α-synuclein in neurodegenerative diseases. The application of PET imaging and computational methods is central to their work, reflecting a focus on advancing diagnostic tools and understanding disease mechanisms.

Best Publications

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • Questionnaire-based assessment of pelvic organ dysfunction in Parkinson's disease

    Ryuji Sakakibara;Hitoshi Shinotoh;Tomoyuki Uchiyama;Mitsufumi Sakuma

  • Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET

    H. Shimada;S. Hirano;H. Shinotoh;A. Aotsuka

  • Manganese intoxication in the rhesus monkey : A clinical, imaging, pathologic, and biochemical study

    C. W. Olanow;P. F. Good;H. Shinotoh;K. A. Hewitt

  • Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease

    Masaomi Iyo;Hiroki Namba;Kiyoshi Fukushi;Hitoshi Shinotoh;Hitoshi Shinotoh

  • High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

    Kenji Tagai;Kenji Tagai;Maiko Ono;Manabu Kubota;Manabu Kubota;Soichiro Kitamura;Soichiro Kitamura

  • Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study.

    Hitoshi Shinotoh;Hiroki Namba;Kiyoshi Fukushi;Shin-Ichiro Nagatsuka

  • Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy

    Hitoshi Shinotoh;Hitoshi Shinotoh;Hiroki Namba;Mika Yamaguchi;Mika Yamaguchi;Kiyoshi Fukushi

  • MRI and PET studies of manganese‐intoxicated monkeys

    H. Shinotoh;B. J. Snow;K. A. Hewitt;B. D. Pate

  • Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study.

    H Shinotoh;O Inoue;K Hirayama;A Aotsuka

  • Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication : A positron emission tomography study

    H. Shinotoh;B. J. Snow;N. S. Chu;C. C. Huang

  • Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET

    H. Shinotoh;A. Aotsuka;K. Fukushi;S. Nagatsuka

  • Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease

    Takaaki Mori;Hitoshi Shimada;Hitoshi Shimada;Hitoshi Shinotoh;Shigeki Hirano;Shigeki Hirano

  • PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

    Yasuyuki Kimura;Masanori Ichise;Hiroshi Ito;Hitoshi Shimada

  • SPECT imaging of the dopamine transporter with [123I]-β-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction

    Ryuji Sakakibara;Hitoshi Shinotoh;Tomoyuki Uchiyama;Mitsuharu Yoshiyama

  • Visualization of specific binding sites of benzodiazepine in human brain.

    Hitoshi Shinotoh;Toshiro Yamasaki;Osamu Inoue;Takashi Itoh

  • Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age

    Hiroki Namba;Masaomi Iyo;Kiyoshi Fukushi;Hitoshi Shinotoh

  • Brain muscarinic receptors in progressive supranuclear palsy and Parkinson’s disease: a positron emission tomographic study

    Masato Asahina;Tetsuya Suhara;Hitoshi Shinotoh;Osamu Inoue

  • In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study ☆

    Michie Miyoshi;Hitoshi Shinotoh;Zbigniew K. Wszolek;Audrey J. Strongosky

  • Parkinsonism induced by solvent abuse

    Ryan J. Uitti;Barry J. Snow;Hitoshi Shinotoh;Francois J. G. Vingerhoets

Frequent Co-Authors

Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Hiroshi Ito
Hiroshi Ito Fukushima Medical University
Harumasa Takano
Harumasa Takano National Institutes for Quantum and Radiological Science and Technology
David Eidelberg
David Eidelberg Feinstein Institute for Medical Research
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Nobuyuki Okamura
Nobuyuki Okamura Tohoku Medical and Pharmaceutical University
Gilles Tamagnan
Gilles Tamagnan Yale University
Tatsushi Toda
Tatsushi Toda University of Tokyo

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