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Molecular Biology

D-Index
54
Citations
10352
World Ranking
2324
National Ranking
1147

Overview

Dieter Egli is affiliated with Columbia University in the United States and conducts research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their scholarly work spans multiple subfields including molecular biology, genetics, surgery, public health, environmental and occupational health, and physiology.

The scientist's research topics focus on pluripotent stem cells, CRISPR and genetic engineering, pancreatic function and diabetes, genetics and neurodevelopmental disorders, genomics and chromatin dynamics, epigenetics and DNA methylation, as well as diabetes and associated disorders.

Among recent publications are:

  • GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration, 2020, Science Translational Medicine
  • Lessons Learned from Somatic Cell Nuclear Transfer, 2020, International Journal of Molecular Sciences
  • Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons, 2021, Journal of Clinical Investigation
  • Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size, 2021, JCI Insight
  • The genetic architecture of DNA replication timing in human pluripotent stem cells, 2021, Nature Communications

Dieter Egli frequently publishes in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Nature Communications
  • Cell Stem Cell
  • Cell Reports

Frequent collaborators include:

  • Michael V. Zuccaro
  • Shuangyi Xu
  • Amnon Koren
  • Lina Sui
  • Qian Du

Best Publications

  • A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

    Justin K. Ichida;Joel Blanchard;Kelvin Lam;Esther Y. Son

  • Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

    Jie Deng;Robert Shoemaker;Bin Xie;Athurva Gore

  • Developmental reprogramming after chromosome transfer into mitotic mouse zygotes

    Dieter Egli;Jacqueline Rosains;Garrett Birkhoff;Kevin Eggan

  • Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

    Daniel Paull;Valentina Emmanuele;Keren A. Weiss;Nathan Treff

  • BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

    Reena Shakya;Latarsha J. Reid;Colleen R. Reczek;Francesca Cole

  • Human oocytes reprogram somatic cells to a pluripotent state

    Scott Noggle;Ho-Lim Fung;Athurva Gore;Hector Martinez

  • Mediators of reprogramming: transcription factors and transitions through mitosis.

    Dieter Egli;Garrett Birkhoff;Kevin Eggan

  • Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos.

    Michael V. Zuccaro;Jia Xu;Carl Mitchell;Diego Marin

  • Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

    Mitsutoshi Yamada;Bjarki Johannesson;Ido Sagi;Lisa Cole Burnett

  • Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.

    Alice E. Chen;Dieter Egli;Kathy Niakan;Jie Deng

  • Digital RNA Allelotyping Reveals Tissue-Specific and Allele-Specific Gene Expression in Human

    Kun Zhang;Jin Billy Li;Yuan Gao;Dieter Egli

  • Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Grafts in a Preclinical Model of Retinitis Pigmentosa

    Yao Li;Yi-Ting Tsai;Chun-Wei Hsu;Deniz Erol

  • The Drosophila Homolog of Mammalian Zinc Finger Factor MTF-1 Activates Transcription in Response to Heavy Metals

    Bo Zhang;Dieter Egli;Oleg Georgiev;Walter Schaffner

  • β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

    Linshan Shang;Haiqing Hua;Haiqing Hua;Kylie Foo;Hector Martinez

  • Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.

    Anand Selvaraj;Kuppusamy Balamurugan;Hasmik Yepiskoposyan;Hao Zhou

  • Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

    Mitsutoshi Yamada;Valentina Emmanuele;Maria J. Sanchez-Quintero;Bruce Sun

  • Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

    George Stratigopoulos;Jayne F. Martin Carli;Diana R. O’Day;Liheng Wang

  • Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc

    Hasmik Yepiskoposyan;Dieter Egli;Tim Fergestad;Anand Selvaraj

  • Derivation and differentiation of haploid human embryonic stem cells

    Ido Sagi;Gloryn Chia;Tamar Golan-Lev;Mordecai Peretz

  • Knockout of ‘metal-responsive transcription factor’ MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis

    Dieter Egli;Anand Selvaraj;Hasmik Yepiskoposyan;Bo Zhang

Frequent Co-Authors

Rudolph L. Leibel
Rudolph L. Leibel Columbia University
Kevin Eggan
Kevin Eggan Harvard University
Oleg Georgiev
Oleg Georgiev University of Zurich
Walter Schaffner
Walter Schaffner University of Zurich
Douglas A. Melton
Douglas A. Melton Harvard University
Nathan R. Treff
Nathan R. Treff Rutgers, The State University of New Jersey
Nissim Benvenisty
Nissim Benvenisty Hebrew University of Jerusalem
Kai Wang
Kai Wang Hebei University
Michio Hirano
Michio Hirano Columbia University
Kun Zhang
Kun Zhang University of California, San Diego

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