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A. A. Leslie Gunatilaka

A. A. Leslie Gunatilaka

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
11575
World Ranking
12060
National Ranking
5165

Overview

A. A. Leslie Gunatilaka is affiliated with the University of Arizona in the United States. Their research spans multiple fields including Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Complementary and Alternative Medicine, Pharmacology, Food Science, and Oncology.

The scientist's work covers several main topics. These include:

  • Phytochemicals and Medicinal Plants
  • Microbial Natural Products and Biosynthesis
  • Plant Biochemistry and Biosynthesis
  • Natural Product Bioactivities and Synthesis
  • Essential Oils and Antimicrobial Activity
  • Fungal Biology and Applications
  • Pharmacological Effects of Medicinal Plants

Gunatilaka has published papers in a range of scientific venues, with the most frequent publication outlets being:

  • Journal of Natural Products
  • Journal of the American Chemical Society
  • Medicinal Chemistry Research
  • ACS Omega
  • Molecules

Selected recent papers demonstrate the scope and topics of the scientist's research:

  • Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases, 2020, Journal of the American Chemical Society
  • Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A-C from guayule (Parthenium argentatum) resin, 2022, Medicinal Chemistry Research
  • Cycloartane- and Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production, 2021, ACS Omega
  • An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus, 2020, Tetrahedron
  • The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels, 2022, British Journal of Pharmacology

Frequent collaborators in their work include the following researchers:

  • E. M. Kithsiri Wijeratne
  • Ya-Ming Xu
  • Manping X. Liu
  • Marielle Cascaes Inácio
  • István Molnár

Best Publications

  • Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence.

    A. A. Leslie Gunatilaka

  • PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

    Shantelle L. LaFayette;Cathy Collins;Aimee K. Zaas;Wiley A. Schell

  • Withaferin A targets heat shock protein 90 in pancreatic cancer cells.

    Yanke Yu;Adel Hamza;Tao Zhang;Mancang Gu

  • Biosynthesis of the Cyclooligomer Depsipeptide Beauvericin, a Virulence Factor of the Entomopathogenic Fungus Beauveria bassiana

    Yuquan Xu;Rousel Orozco;E.M. Kithsiri Wijeratne;A.A. Leslie Gunatilaka

  • Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum.

    Jixun Zhan;Anna M. Burns;Manping X. Liu;Stanley H. Faeth

  • Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana.

    Yuquan Xu;Rousel Orozco;E.M. Kithsiri Wijeratne;Patricia Espinosa-Artiles

  • Minor and trace sterols in marine invertebrates. 26. Isolation and structure elucidation of nine new 5.alpha.,8.alpha.-epidoxy sterols from four marine organisms

    A. A. Leslie Gunatilaka;A. A. Leslie Gunatilaka;Yalamanchili Gopichand;Francis J. Schmitz;Carl Djerassi

  • Differential control of growth, cell cycle progression, and expression of NF-κB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens

    Tze Chen Hsieh;E. Kithsiri Wijeratne;Jing Yu Liang;A. Leslie Gunatilaka

  • Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.

    Thomas J. Turbyville;E. M. Kithsiri Wijeratne;Manping X. Liu;Anna M. Burns

  • A Rhizosphere Fungus Enhances Arabidopsis Thermotolerance through Production of an HSP90 Inhibitor

    Catherine A. McLellan;Thomas J. Turbyville;E.M. Kithsiri Wijeratne;Arthur Kerschen

  • Actin microfilament aggregation induced by withaferin A is mediated by annexin II

    Ryan R Falsey;Marilyn T Marron;G M Kamal B Gunaherath;Nikhil Shirahatti

  • Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.

    Ajith P.K Nissanka;Veranja Karunaratne;B.M.Ratnayake Bandara;Vijaya Kumar

  • Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

    Sandro Santagata;Ya Ming Xu;E. M.Kithsiri Wijeratne;Renee Kontnik

  • Uncovering biosynthetic potential of plant-associated fungi: Effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii

    Priyani A Paranagama;E M Kithsiri Wijeratne;A A Leslie Gunatilaka

  • Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants.

    Jian He;E. M. Kithsiri Wijeratne;Bharat P. Bashyal;Jixun Zhan

  • Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum.

    Bharat P Bashyal;E M Kithsiri Wijeratne;Stanley H Faeth;A A Leslie Gunatilaka

  • Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities

    Ashok G. Chaudhary;Milind M. Gharpure;John M. Rimoldi;Mahendra D. Chordia

  • Heptaketides from Corynespora sp. inhabiting the cavern beard lichen, Usnea cavernosa: first report of metabolites of an endolichenic fungus.

    Priyani A. Paranagama;E. M. Kithsiri Wijeratne;Anna M. Burns;Marilyn T. Marron

  • Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii.

    Shuhao Wang;Yuquan Xu;Erin A. Maine;E.M. Kithsiri Wijeratne

  • Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.

    Linda C. Meade-Tollin;E. M.Kithsiri Wijeratne;Deborah Cooper;Mischa Guild

Frequent Co-Authors

A. Elizabeth Arnold
A. Elizabeth Arnold University of Arizona
Vanderlan da Silva Bolzani
Vanderlan da Silva Bolzani Sao Paulo State University
Yasuhiro Tezuka
Yasuhiro Tezuka Hokuriku University
Thomas J. Sayers
Thomas J. Sayers Leidos (United States)
Hans D. VanEtten
Hans D. VanEtten University of Arizona
Donna D. Zhang
Donna D. Zhang University of Arizona
Stanley H. Faeth
Stanley H. Faeth University of North Carolina at Greensboro
Rajesh Khanna
Rajesh Khanna University of Florida

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