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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
8806
World Ranking
16779
National Ranking
6925

Overview

Thomas J. Sayers is affiliated with Leidos in the United States and has contributed to research primarily in the fields of biochemistry, genetics and molecular biology, immunology and microbiology, and medicine. Their work spans several subfields including molecular biology, immunology, oncology, and complementary and alternative medicine.

The main topics of study in their research include cell death mechanisms and regulation, immunotherapy and immune responses, RNA interference and gene delivery, phytochemicals and medicinal plants, PARP inhibition in cancer therapy, CAR-T cell therapy research, and immune cell function and interaction.

Sayers has published research in multiple scientific venues. Frequent publication platforms for their work are:

  • Cancer Research
  • Journal of Natural Products
  • Frontiers in Immunology

Selected publications by Thomas J. Sayers include:

  • Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins, 2021, Cancer Research
  • Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma, 2021, Journal of Natural Products
  • CD8+ T-NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen-escape tumors, 2025, Frontiers in Immunology

The scientist has worked with several frequent co-authors, including:

  • Poonam Tewary
  • Alan D. Brooks
  • Ya-Ming Xu
  • E. M. Kithsiri Wijeratne
  • Maria Teresa P. de Aquino

Best Publications

  • Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.

    D. D. Taub;T. J. Sayers;C. R. D. Carter;J. R. Ortaldo

  • Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes

    Karin A Sedelies;Thomas J Sayers;Kirsten M Edwards;Weisan Chen

  • Identification of Human Neutrophil-derived Cathepsin G and Azurocidin/CAP37 as Chemoattractants for Mononuclear Cells and Neutrophils

    Oleg Chertov;Hirotsugu Ueda;Luo Ling Xu;Kenji Tani

  • Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib

    Kai Sun;Lisbeth A. Welniak;Angela Panoskaltsis-Mortari;Matthew J. O'Shaughnessy

  • Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

    Ancy D. Nalli;Lauren E. Brown;Cheryl L. Thomas;Thomas J. Sayers

  • Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy

    Kazuyoshi Takeda;Noriko Yamaguchi;Hisaya Akiba;Yuko Kojima

  • Targeting the extrinsic apoptosis signaling pathway for cancer therapy.

    Thomas J. Sayers

  • The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.

    Thomas J. Sayers;Alan D. Brooks;Crystal Y. Koh;Weihong Ma

  • The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

    Kyungjae Kim;Chong-kil Lee;Thomas J. Sayers;Kathrin Muegge

  • Unlocking the secrets of cytotoxic granule proteins

    Mark J. Smyth;Janice M. Kelly;Vivien R. Sutton;Joanne E. Davis

  • NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer

    Mark J. Smyth;Jeremy Swann;Janice M. Kelly;Erika Cretney

  • NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype

    Erik Ames;Robert J. Canter;Steven K. Grossenbacher;Stephanie Mac

  • New flow cytometric assays for monitoring cell-mediated cytotoxicity.

    Liubov Zaritskaya;Michael R Shurin;Thomas J Sayers;Anatoli M Malyguine

  • Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin.

    Naoko Seki;Alan D. Brooks;Clive R. D. Carter;Timothy C. Back

  • Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.

    T J Sayers;T A Wiltrout;C A Bull;A C Denn rd

  • Synthesis of potential anticancer agents.

    Charles E. Williamson;Thomas J. Sayers;Arnold M. Seligman;Benjamin. Witten

  • Sensitization of Tumor Cells to NK Cell-Mediated Killing by Proteasome Inhibition

    William H.D. Hallett;Erik Ames;Milad Motarjemi;Isabel Barao

  • Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity

    Kai Sun;Danice E. C. Wilkins;Miriam R. Anver;Thomas J. Sayers

  • The Granzyme B ELISPOT assay: an alternative to the 51Cr-release assay for monitoring cell-mediated cytotoxicity.

    Kimberly A Shafer-Weaver;Thomas J Sayers;Susan Strobl;E G Derby

  • Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.

    Naoko Seki;Yoshihiro Hayakawa;Alan D. Brooks;John Wine

Frequent Co-Authors

William J. Murphy
William J. Murphy Texas A&M University
Robert H. Wiltrout
Robert H. Wiltrout National Institutes of Health
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Jon M. Wigginton
Jon M. Wigginton Bristol-Myers Squibb (Germany)
Hideo Yagita
Hideo Yagita Juntendo University
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
A. A. Leslie Gunatilaka
A. A. Leslie Gunatilaka University of Arizona
James B. McMahon
James B. McMahon National Institutes of Health
John R. Ortaldo
John R. Ortaldo National Institutes of Health
Dan L. Longo
Dan L. Longo Harvard University

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