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Immunology
Sweden
2022

D-Index & Metrics

Immunology

D-Index
96
Citations
24325
World Ranking
869
National Ranking
14

Medicine

D-Index
97
Citations
24459
World Ranking
9443
National Ranking
188

Research.com Recognitions

  • 2022 - Research.com Immunology in Sweden Leader Award

Overview

Jan Holmgren is affiliated with the University of Gothenburg in Sweden and has a focus on research in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, primarily endocrinology, infectious diseases, epidemiology, immunology, and health. Holmgren's research covers key topics such as Vibrio bacteria studies, Escherichia coli investigations, viral gastroenteritis epidemiology, influenza virus studies, vaccine coverage and hesitancy, child nutrition and water access, and antibiotic resistance in bacteria.

Their recent publications showcase a range of contributions to vaccine development and infectious disease understanding. Notable papers include:

  • "An Update on Cholera Immunity and Current and Future Cholera Vaccines," 2021, Tropical Medicine and Infectious Disease
  • "Modern History of Cholera Vaccines and the Pivotal Role of icddr,b," 2021, The Journal of Infectious Diseases

Holmgren's research network includes frequent collaborations with Michael Lebens, Manuela Terrinoni, Stefan Nordqvist, Tarun Kumar Sharma, and Madeleine Löfstrand.

Their work is often published in venues related to vaccines and immunology, with multiple publications in:

  • Vaccine
  • Mucosal Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Vaccines
  • Journal of Travel Medicine

Among the recent papers associated with Holmgren's research interests and collaborations are contributions to the development and evaluation of vaccines for cholera and enterotoxigenic Escherichia coli, including studies on oral inactivated vaccines. These include trials assessing safety, immunogenicity, and tolerability across varied populations and geographic regions.

Best Publications

  • Identification ofEscherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure

    Ann-Mari Svennerholm;Jan Holmgren

  • Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.

    M Quiding-Järbrink;I Nordström;G Granström;A Kilander

  • Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh.

    G. Balakrish Nair;Firdausi Qadri;Jan Holmgren;Ann Mari Svennerholm

  • Cholera toxin structure, gene regulation and pathophysiological and immunological aspects

    J. Sánchez;J. Holmgren

  • Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

    J Sanchez;J Holmgren

  • Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial.

    Dipika Sur;Anna Lena Lopez;Suman Kanungo;Allison Paisley

  • Mucosal Immunity: Implications for Vaccine Development

    Jan Holmgren;Cecil Czerkinsky;Nils Lycke;Ann-Mari Svennerholm

  • Seroepidemiological Studies of El Tor Cholera in Bangladesh: Association of Serum Antibody Levels with Protection

    Roger I. Glass;Ann-Mari Svennerholm;M. R. Khan;Shamsul Huda

  • Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory.

    M Quiding;I Nordström;A Kilander;G Andersson

  • 5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind, placebo-controlled trial.

    Sujit K Bhattacharya;Dipika Sur;Mohammad Ali;Suman Kanungo

  • Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease.

    M Jertborn;A M Svennerholm;J Holmgren

  • Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

    Annakari Bromander;Jan Holmgren;Nils Lycke

  • Nasal and Vaginal Vaccinations Have Differential Effects on Antibody Responses in Vaginal and Cervical Secretions in Humans

    Eva-Liz Johansson;Lotta Wassén;Jan Holmgren;Marianne Jertborn

  • Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea

    Joaquín Sánchez;Jan Holmgren

  • Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin.

    R E Black;M M Levine;M L Clements;C R Young

  • Monoclonal antibodies against Escherichia coli heat-stable toxin (STa) and their use in a diagnostic ST ganglioside GM1-enzyme-linked immunosorbent assay.

    A M Svennerholm;M Wikström;M Lindblad;J Holmgren

  • Distribution of lymphocytes and adhesion molecules in human cervix and vagina.

    E L Johansson;A Rudin;L Wassén;J Holmgren

  • Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

    Jia-Bin Sun;Carola Rask;Tomas Olsson;Jan Holmgren

  • A Protective Role of Locally Administered Immunostimulatory CpG Oligodeoxynucleotide in a Mouse Model of Genital Herpes Infection

    Ali M. Harandi;Kristina Eriksson;Jan Holmgren

  • Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice.

    S. Raghavan;M. Fredriksson;A.-M. Svennerholm;J. Holmgren

Frequent Co-Authors

Ann-Mari Svennerholm
Ann-Mari Svennerholm University of Gothenburg
Cecil Czerkinsky
Cecil Czerkinsky Université Côte d'Azur
David A. Sack
David A. Sack Johns Hopkins University
John D. Clemens
John D. Clemens University of California, Los Angeles
Lars Svennerholm
Lars Svennerholm University of Gothenburg
L. Å. Hanson
L. Å. Hanson University of Gothenburg
Seung Hyun Han
Seung Hyun Han Seoul National University
Teresa Lagergård
Teresa Lagergård University of Gothenburg
Nils Lycke
Nils Lycke University of Gothenburg
Timothy R. Hirst
Timothy R. Hirst University of Adelaide

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