Lloyd W. Ruddock

Overview

Best Publications

• The human protein disulphide isomerase family: substrate interactions and functional properties

  Lars Ellgaard;Lloyd W. Ruddock

  952
  Citations

• Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation.

  Feras Hatahet;Lloyd W. Ruddock

  755
  Citations

• The b′ domain provides the principal peptide‐binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins

  Peter Klappa;Lloyd W. Ruddock;Nigel J. Darby;Nigel J. Darby;Robert B. Freedman

  420
  Citations

• Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation

  Christoph Reinhardt;Marie Luise Von Brühl;Davit Manukyan;Lenka Grahl

  369
  Citations

• N-glycan processing in ER quality control.

  Lloyd W. Ruddock;Maurizio Molinari

  363
  Citations

• Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

  Van Dat Nguyen;Mirva J. Saaranen;Anna-Riikka Karala;Anna-Kaisa Lappi

  328
  Citations

• A molecular specificity code for the three mammalian KDEL receptors

  Irina Raykhel;Heli Alanen;Kirsi Salo;Jaana Jurvansuu

  319
  Citations

• Protein disulfide isomerases exploit synergy between catalytic and specific binding domains.

  Robert B. Freedman;Peter Klappa;Lloyd W. Ruddock

  259
  Citations

• Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli

  Van Dat Nguyen;Feras Hatahet;Kirsi E H Salo;Eveliina Enlund

  237
  Citations

• Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI(+)] of Saccharomyces cerevisiae.

  Simon S. Eaglestone;Lloyd W. Ruddock;Brian S. Cox;Mick F. Tuite

  234
  Citations

• EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

  Silvia Olivari;Tito Cali;Kirsi E.H. Salo;Paolo Paganetti

  214
  Citations

• A Major Fraction of Endoplasmic Reticulum-located Glutathione Is Present as Mixed Disulfides with Protein

  Rosemary Bass;Lloyd W. Ruddock;Peter Klappa;Robert B. Freedman

  203
  Citations

• A Novel Stress-induced EDEM Variant Regulating Endoplasmic Reticulum-associated Glycoprotein Degradation

  Silvia Olivari;Carmela Galli;Heli Alanen;Lloyd Ruddock

  202
  Citations

• Substrate recognition by the protein disulfide isomerases

  Feras Hatahet;Lloyd W. Ruddock

  196
  Citations

• Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase.

  Annamari Pirneskoski;Peter Klappa;Mario Lobell;Richard A. Williamson

  188
  Citations

• A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases.

  Anna Kaisa A.K. Lappi;Marc Lensink;Heli H.I. Alanen;Kirsi E H K.E.H. Salo

  157
  Citations

• Insights into Deglutathionylation Reactions DIFFERENT INTERMEDIATES IN THE GLUTAREDOXIN AND PROTEIN DISULFIDE ISOMERASE CATALYZED REACTIONS ARE DEFINED BY THE γ-LINKAGE PRESENT IN GLUTATHIONE

  Mirva J. Peltoniemi;Anna-Riikka Karala;Jaana K. Jurvansuu;Vuokko L. Kinnula

  152
  Citations

• Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain.

  Van Dat Nguyen;Katrine Wallis;Mark J. Howard;Antti M. Haapalainen

  147
  Citations

• Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of E. coli.

  Feras Hatahet;Van Dat Nguyen;Kirsi E H Salo;Lloyd W Ruddock

  143
  Citations

• pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: studies with a novel simple peptide substrate

  Lloyd W. Ruddock;Timothy R. Hirst;Robert B. Freedman

  132
  Citations