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Kazuhisa Yamazaki

Kazuhisa Yamazaki

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
12120
World Ranking
12565
National Ranking
860

Overview

Kazuhisa Yamazaki is affiliated with Niigata University in Japan and focuses research efforts primarily on dentistry, biochemistry, genetics and molecular biology, and medicine. Their extensive work is notably concentrated within the subfields of periodontics, molecular biology, physiology, neurology, and epidemiology.

The scientist's key topics of research include oral microbiology and periodontitis research, gut microbiota and health, salivary gland disorders and functions, dental health and care utilization, barrier structure and function studies, liver disease diagnosis and treatment, as well as diet and metabolism studies.

Yamazaki's recent scholarly publications encompass studies that explore the interaction between oral and gut microbiomes and their systemic effects. Some of the recent papers are:

  • "Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid," 2021, published in mBio
  • "Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice," 2021, published in Journal of Periodontal Research
  • "Oral-gut axis as a novel biological mechanism linking periodontal disease and systemic diseases: A review," 2023, published in Japanese Dental Science Review
  • "Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice," 2021, published in Frontiers in Immunology
  • "Orally administered pathobionts and commensals have comparable and innocuous systemic effects on germ-free mice," 2020, published in Microbial Pathogenesis

Yamazaki frequently collaborates with several coauthors, including Kyoko Yamazaki, Takahiro Tsuzuno, Miki Yamada-Hara, Naoki Takahashi, and Mai Yokoji-Takeuchi. Collaboration is a substantial element in their research activities.

The scientist's publications have appeared in various prominent venues, with multiple papers featured in the Journal of Oral Microbiology, as well as contributions to mBio, Journal of Periodontal Research, Japanese Dental Science Review, and Frontiers in Immunology.

Best Publications

  • Relationship between periodontal infections and systemic disease

    G.J. Seymour;P.J. Ford;M.P. Cullinan;M.P. Cullinan;S. Leishman

  • Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota.

    Kei Arimatsu;Hitomi Yamada;Haruna Miyazawa;Takayoshi Minagawa

  • Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

    Søren Jepsen;Jack G. Caton;Jasim M. Albandar;Nabil Fouad Bissada

  • Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

    Mayuka Nakajima;Kei Arimatsu;Tamotsu Kato;Yumi Matsuda

  • Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions: Classification and case definitions for periodontal manifestations of systemic diseases and developmental and acquired conditions

    Søren Jepsen;Jack G. Caton;Jasim M. Albandar;Nabil F. Bissada

  • Can oral bacteria affect the microbiome of the gut

    Ingar Olsen;Kazuhisa Yamazaki

  • FGF-2 Stimulates Periodontal Regeneration Results of a Multi-center Randomized Clinical Trial

    M. Kitamura;M. Akamatsu;M. MacHigashira;Y. Hara

  • Destructive periodontitis lesions are determined by the nature of the lymphocytic response.

    E. Gemmell;K. Yamazaki;G.J. Seymour

  • Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients.

    Kazuhisa Yamazaki;Tomoyuki Honda;Taro Oda;Kaoru Ueki-Maruyama

  • The role of T cells in periodontal disease: homeostasis and autoimmunity.

    Erica Gemmell;Kazuhisa Yamazaki;Gregory J. Seymour

  • Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts.

    Kouich Tabeta;Kazuhisa Yamazaki;Sachiko Akashi;Kensuke Miyake

  • Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.

    T. Nakajima;T. Honda;H. Domon;T. Okui

  • Regulatory T-cells Infiltrate Periodontal Disease Tissues

    T. Nakajima;K. Ueki-Maruyama;T. Oda;Y. Ohsawa

  • IL-4- and IL-6-producing cells in human periodontal disease tissue

    Kazuhisa Yamazaki;Takako Nakajima;Erica Gemmell;Boris Polak

  • Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients

    K Tabeta;K Yamazaki;H Hotokezaka;H Yoshie

  • Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions.

    T. Honda;H. Domon;T. Okui;K. Kajita

  • Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system

    Keisuke Sato;Naoki Takahashi;Tamotsu Kato;Yumi Matsuda

  • Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome.

    Tamotsu Kato;Kyoko Yamazaki;Mayuka Nakajima;Yasuhiro Date

  • Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile.

    Tomoki Maekawa;Naoki Takahashi;Koichi Tabeta;Yukari Aoki

  • Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease

    Kazuhisa Yamazaki;Takako Nakajima;Toshihiko Aoyagi;Kohji Hara

Frequent Co-Authors

Gregory J. Seymour
Gregory J. Seymour University of Queensland
Shinya Murakami
Shinya Murakami Osaka University
Kazuo Miyashita
Kazuo Miyashita Obihiro University of Agriculture and Veterinary Medicine
Hidemi Kurihara
Hidemi Kurihara Hiroshima University
Jun Ogawa
Jun Ogawa Kyoto University
Yoshifusa Aizawa
Yoshifusa Aizawa Tachikawa Medical Center
Yoshimitsu Abiko
Yoshimitsu Abiko Nihon University
Lijian Jin
Lijian Jin University of Hong Kong
Anton Sculean
Anton Sculean University of Bern

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