World's Best Scientists 2026 revealed!
Michaela U. Gack

Michaela U. Gack

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
25239
World Ranking
17808
National Ranking
7288

Overview

Michaela U. Gack is affiliated with the Cleveland Clinic in the United States and has a research portfolio centered on medicine, immunology, microbiology, and molecular biology. Their work primarily spans infectious diseases and immunology, with significant contributions to the study of interferon and immune responses, SARS-CoV-2 and COVID-19 research, and the investigation of immune disorders.

The scientist's research topics include:

  • Interferon and immune responses
  • SARS-CoV-2 and COVID-19 research
  • COVID-19 clinical research studies
  • Inflammasome and immune disorders
  • Immune response and inflammation
  • Viral infections and vectors
  • Cytomegalovirus and herpesvirus research

Gack has authored multiple research articles published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Proceedings of the National Academy of Sciences, Nature Reviews Immunology, and PLoS Biology. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Nature reviews. Immunology
  • PLoS Biology

Recent significant papers by Michaela U. Gack include:

  • "RIG-I-like receptors: their regulation and roles in RNA sensing," 2020, Nature reviews. Immunology
  • "Dysregulation of type I interferon responses in COVID-19," 2020, Nature reviews. Immunology
  • "ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity," 2021, Nature Microbiology
  • "A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19," 2020, PLoS Biology
  • "Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2," 2021, PLoS Pathogens

Gack frequently collaborates with other researchers in their field. Notable co-authors include Guanqun Liu, Dhiraj Acharya, Junji Zhu, Zuberwasim Sayyad, and Cindy Chiang.

The scientist's extensive contributions mainly cover the subfields of infectious diseases, immunology, molecular biology, epidemiology, and oncology, with a focus on understanding host-pathogen interactions and immune system mechanisms related to viral infections and inflammatory processes.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

    Michaela U. Gack;Young C. Shin;Chul Hyun Joo;Chul Hyun Joo;Tomohiko Urano;Tomohiko Urano

  • RIG-I-like receptors: their regulation and roles in RNA sensing

    Jan Rehwinkel;Michaela U. Gack

  • Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

    Michaela Ulrike Gack;Randy Allen Albrecht;Tomohiko Urano;Tomohiko Urano;Kyung-Soo Inn;Kyung-Soo Inn

  • Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

    Chengyu Liang;Chengyu Liang;Jong-soo Lee;Jong-soo Lee;Kyung-Soo Inn;Kyung-Soo Inn;Michaela U. Gack;Michaela U. Gack

  • Cytosolic Viral Sensor RIG-I Is a 5′-Triphosphate-Dependent Translocase on Double-Stranded RNA

    Su-A Myong;Sheng Cui;Peter V. Cornish;Peter V. Cornish;Axel Kirchhofer

  • Viral evasion of intracellular DNA and RNA sensing

    Ying Kai Chan;Michaela U. Gack

  • Dysregulation of type I interferon responses in COVID-19.

    Dhiraj Acharya;Guan Qun Liu;Michaela U. Gack

  • Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

    Ricardo Rajsbaum;Randy A. Albrecht;May K. Wang;Natalya P. Maharaj

  • Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling

    Effi Wies;May K. Wang;Natalya P. Maharaj;Kan Chen

  • Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

    Michaela U. Gack;Axel Kirchhofer;Young C. Shin;Kyung Soo Inn;Kyung Soo Inn

  • TRIM Proteins and Their Roles in Antiviral Host Defenses

    Michiel van Gent;Konstantin M.J. Sparrer;Michaela U. Gack

  • ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.

    GuanQun Liu;GuanQun Liu;Jung-Hyun Lee;Jung-Hyun Lee;Zachary M. Parker;Dhiraj Acharya;Dhiraj Acharya

  • Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

    Jessica J Chiang;Konstantin M J Sparrer;Michiel van Gent;Charlotte Lässig

  • Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

    Kyung-Soo Inn;Michaela U. Gack;Michaela U. Gack;Fuminori Tokunaga;Mude Shi

  • TRIM23 mediates virus-induced autophagy via activation of TBK1

    Konstantin M. J. Sparrer;Sebastian Gableske;Matthew A. Zurenski;Zachary M. Parker

  • RIG-I-like receptor regulation in virus infection and immunity.

    Ying Kai Chan;Michaela U Gack

  • Ubiquitination in the antiviral immune response

    Meredith E. Davis;Michaela U. Gack

  • Post-translational Control of Intracellular Pathogen Sensing Pathways

    Cindy Chiang;Michaela U. Gack

  • Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3

    Chul Hyun Joo;Young C. Shin;Michaela Gack;Liguo Wu

Frequent Co-Authors

Jae U. Jung
Jae U. Jung Cleveland Clinic
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
Lara Jehi
Lara Jehi Cleveland Clinic
Nicos A. Nicola
Nicos A. Nicola Walter and Eliza Hall Institute of Medical Research
Jeffrey J. Babon
Jeffrey J. Babon Walter and Eliza Hall Institute of Medical Research
Sandra E. Nicholson
Sandra E. Nicholson Walter and Eliza Hall Institute of Medical Research
Karl-Peter Hopfner
Karl-Peter Hopfner Ludwig-Maximilians-Universität München
Satoshi Inoue
Satoshi Inoue Saitama Medical University
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai
Charis Eng
Charis Eng Cleveland Clinic Lerner College of Medicine

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