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Biology and Biochemistry

D-Index
68
Citations
16962
World Ranking
7775
National Ranking
245

Overview

Karl Wah Keung Tsim is affiliated with the Hong Kong University of Science and Technology in China. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on several interconnected subfields.

The main subfields of Karl Wah Keung Tsim's research include Molecular Biology, Pharmacology, Complementary and Alternative Medicine, Physiology, and Plant Science. This diverse spectrum aligns with their investigation into multiple topics related to neurodegenerative diseases and medicinal plant applications.

Key research topics addressed in their work are:

  • Cholinesterase and Neurodegenerative Diseases
  • Alzheimer's Disease Research and Treatments
  • Nicotinic Acetylcholine Receptors Study
  • Traditional Chinese Medicine Analysis
  • Medicinal Plants and Neuroprotection
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Ginseng Biological Effects and Applications

Karl Wah Keung Tsim has contributed extensively to academic journals, frequently publishing in the following venues:

  • Frontiers in Pharmacology
  • Phytomedicine
  • Molecules
  • Journal of Ethnopharmacology
  • The FASEB Journal

The recent papers authored or coauthored by Karl Wah Keung Tsim include:

  • Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer, 2020, Phytomedicine
  • A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence, 2020, Frontiers in Pharmacology
  • Piceatannol, a Natural Analog of Resveratrol, Exerts Anti-angiogenic Efficiencies by Blockage of Vascular Endothelial Growth Factor Binding to Its Receptor, 2020, Molecules
  • Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways, 2020, The FASEB Journal
  • Interacting with 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages, 2020, Acta Pharmaceutica Sinica B

They have collaborated frequently with several coauthors, including:

  • Tina Ting-Xia Dong
  • Tina T. X. Dong
  • Yingjie Xia
  • Maggie Suisui Guo
  • Shengying Lin

Best Publications

  • Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations.

    Xia Q. Ma;Q. Shi;Jinao Duan;Ting Xia Dong

  • Quality control of Cordyceps sinensis, a valued traditional Chinese medicine.

    Shaoping Li;Fengqing Yang;Karl Wah Keung Tsim

  • The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

    Markus A. Ruegg;Karl W.K. Tsim;Sharon E. Horton;Stephan Kröger

  • A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury.

    Shaoping Li;Kuijun Zhao;Zhaoning Ji;Zong H. Song

  • Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia.

    Shaoping Li;Shaoping Li;Guihong Zhang;Qingshu Zeng;Zhaogang Huang

  • Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents.

    Tina Tingxia Dong;Xiuming Cui;Zong H. Song;Kuijun Zhao

  • cDNA that encodes active agrin.

    Karl Wah Keung Tsim;Markus Andreas Rüegg;Gérard Escher;Stephan Kröger

  • Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia.

    Shao Ping Li;Shao Ping Li;Ping Li;Tina Tingxia Dong;Karl Wah Keung Tsim

  • Molecular genetic and chemical assessment of radix Angelica (Danggui) in China.

    Kuijun Zhao;Tina Tingxia Dong;Pengfei Tu;Zong H. Song

  • Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction.

    Amy Kit Yu Fu;Wing Yu Fu;Janet Cheung;Karl Wah Keung Tsim

  • Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells : A comparison of different flavonoids in activating estrogenic effect and in preventing β-amyloid-induced cell death

    Judy T T Zhu;Roy C Y Choi;Glanice K Y Chu;Anna W H Cheung

  • Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer.

    Jian Shu Lou;Li Ping Zhao;Zhi Hui Huang;Xia Yin Chen

  • Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.

    Tina Tingxia Dong;Kuijun Zhao;Qiutao Gao;Zhaoning Ji

  • Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction

    Sincheng Lao;Shaoping Li;Kelvin K.W. Kan;Peng Li

  • Determination of nucleosides in natural Cordyceps sinensis and cultured Cordyceps mycelia by capillary electrophoresis.

    Shao Ping Li;Shao Ping Li;Ping Li;Tina Tingxia Dong;Karl Wah Keung Tsim

  • Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography

    Shaoping Li;Peng Li;C.M. Lai;Yuanxiang Gong

  • Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: orthogonal array design to optimize the extraction of chemical constituents

    Zong H. Song;Zhao N. Ji;Chun K. Lo;Tina T. X. Dong

  • Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry.

    Fengqing Yang;Shaoping Li;Ying Chen;Sincheng Lao

  • Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors

    Wenming Li;Rongbiao Pi;Hugh H.N. Chan;Hongjun Fu

  • Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages.

    Jianping Chen;Zhonggui Li;Maitinuer Maiwulanjiang;Wendy L Zhang

Frequent Co-Authors

Jun Li
Jun Li Applied Biological Materials (Canada)
Nancy Y. Ip
Nancy Y. Ip Hong Kong University of Science and Technology
Yuan Ping Pang
Yuan Ping Pang Mayo Clinic
Shao-Ping Li
Shao-Ping Li University of Macau
Yung Hou Wong
Yung Hou Wong Hong Kong University of Science and Technology
Zhengtao Wang
Zhengtao Wang Shanghai University
Jean Massoulié
Jean Massoulié École Normale Supérieure
Peng-Fei Tu
Peng-Fei Tu Peking University
Jin-Ao Duan
Jin-Ao Duan Nanjing University of Chinese Medicine
Eric A. Barnard
Eric A. Barnard University of Cambridge

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