Yoshihiro Nakata

Best Publications

• Production and Release of Neuroprotective Tumor Necrosis Factor by P2X7 Receptor-Activated Microglia

  Tomohisa Suzuki;Izumi Hide;Katsutoshi Ido;Shinichi Kohsaka

  574
  Citations

• Extracellular ATP Triggers Tumor Necrosis Factor-α Release from Rat Microglia

  Izumi Hide;Masaya Tanaka;Atsuko Inoue;Kazuyuki Nakajima

  517
  Citations

• Microglial α7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role

  Tomohisa Suzuki;Izumi Hide;Akiyo Matsubara;Chihiro Hama

  325
  Citations

• Interleukin-1beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system.

  Inoue A;Ikoma K;Morioka N;Kumagai K

  247
  Citations

• Aripiprazole, a novel antipsychotic drug, inhibits quinpirole-evoked GTPase activity but does not up-regulate dopamine D2 receptor following repeated treatment in the rat striatum.

  Atsuko Inoue;Sinya Miki;Mayumi Seto;Tetsuro Kikuchi

  143
  Citations

• Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells

  Kazue Hisaoka;Minoru Takebayashi;Mami Tsuchioka;Natsuko Maeda

  134
  Citations

• Substance P: Regional distribution and specific binding to synaptic membranes in rabbit central nervous system☆

  Yoshihiro Nakata;Yoshiko Kusaka;Tomio Segawa;Haruaki Yajima;Haruaki Yajima

  115
  Citations

• Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline

  Naoto Kajitani;Kazue Hisaoka-Nakashima;Norimitsu Morioka;Mami Okada-Tsuchioka

  104
  Citations

• Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1

  Yoki Nakamura;Norimitsu Morioka;Hiromi Abe;Fang Fang Zhang

  98
  Citations

• Serotonin (5‐HT) induces glial cell line‐derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells

  Mami Tsuchioka;Minoru Takebayashi;Kazue Hisaoka;Natsuko Maeda

  94
  Citations

• Sensitization of Vanilloid Receptor 1 Induced by Bradykinin via the Activation of Second Messenger Signaling Cascades in Rat Primary Afferent Neurons

  He-Bin Tang;Atsuko Inoue;Kyoko Oshita;Yoshihiro Nakata

  93
  Citations

• Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway.

  N Morioka;K Suekama;F F Zhang;N Kajitani

  90
  Citations

• Possible Involvement of P2X7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats

  Daijiro Yanagisawa;Yoshihisa Kitamura;Kazuyuki Takata;Izumi Hide

  84
  Citations

• Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.

  Kazue Hisaoka;Mami Tsuchioka;Ryoya Yano;Natsuko Maeda

  83
  Citations

• Active uptake of substance P carboxy-terminal heptapeptide (5-11) into rat brain and rabbit spinal cord slices.

  Yoshihiro Nakata;Yoshiko Kusaka;Haruaki Yajima;Tomio Segawa

  82
  Citations

• Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice.

  Norimitsu Morioka;Fang Fang Zhang;Yoki Nakamura;Tomoya Kitamura

  81
  Citations

• Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice.

  Katsuya Morita;Norimitsu Morioka;Joynal Abdin;Shigeo Kitayama

  80
  Citations

• Interleukin-1β-induced substance P release from rat cultured primary afferent neurons driven by two phospholipase A2 enzymes: secretory type IIA and cytosolic type IV

  Norimitsu Morioka;Kazumi Takeda;Kei Kumagai;Tomohiko Hanada

  79
  Citations

• Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

  Kazue Hisaoka-Nakashima;Naoto Kajitani;Masahiro Kaneko;Takahiro Shigetou

  78
  Citations

• Effects of σ1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats

  Li Bo Zou;Kiyofumi Yamada;Masashi Sasa;Yoshihiro Nakata

  78
  Citations

• Supersensitivity to substance P after dorsal root section

  Yoshihiro Nakata;Yoshiko Kusaka;Tomio Segawa

  73
  Citations

• Nitric oxide synergistically potentiates interleukin-1β-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms

  N Morioka;A Inoue;T Hanada;K Kumagai

  71
  Citations