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Wayne R. Giles

Wayne R. Giles

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
22219
World Ranking
3924
National Ranking
127

Overview

Wayne R. Giles is affiliated with the University of Calgary in Canada. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable focus on Cardiology and Cardiovascular Medicine, Molecular Biology, Physiology, Cell Biology, and Cellular and Molecular Neuroscience.

The scientist's main topics of work include:

  • Ion channel regulation and function
  • Cardiac electrophysiology and arrhythmias
  • Atrial Fibrillation Management and Outcomes
  • Cardiomyopathy and Myosin Studies
  • Electrochemical Analysis and Applications
  • Neurobiology and Insect Physiology Research
  • Osteoarthritis Treatment and Mechanisms

Recent papers authored or co-authored by Wayne R. Giles cover a range of topics related to cardiac function and cellular physiology. These include:

  • "Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death" (2020, Circulation Research)
  • "Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+-current block in atrial fibrillation" (2020, British Journal of Pharmacology)
  • "From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology" (2021, Frontiers in Physiology)
  • "A molecular complex of Ca v 1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling" (2022, Proceedings of the National Academy of Sciences)
  • "K+ and Ca2+ Channels Regulate Ca2+ Signaling in Chondrocytes: An Illustrated Review" (2020, Cells)

Frequent co-authors collaborating with Wayne R. Giles include:

  • Yoshiaki Suzuki
  • Sanjiv M. Narayan
  • Hisao Yamamura
  • Andrew G. Edwards
  • Karoline Horgmo Jæger

Wayne R. Giles has published multiple papers in a variety of scientific venues. Some of the frequent publication outlets are:

  • Frontiers in Physiology
  • Scientific Reports
  • American Journal of Physiology-Cell Physiology
  • Inflammation and Regeneration
  • Bioelectricity

Best Publications

  • Cardiac pacemaking in the sinoatrial node

    H. Irisawa;H. F. Brown;W. Giles

  • Spatiotemporal evolution of ventricular fibrillation

    Francis X. Witkowski;L. Joshua Leon;Patricia A. Penkoske;Wayne R. Giles

  • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.

    Susumu Minamisawa;Masahiko Hoshijima;Guoxiang Chu;Christopher A Ward

  • Cardiac fibroblasts: friend or foe?

    Troy A. Baudino;Wayne Carver;Wayne Giles;Thomas K. Borg

  • Comparison of potassium currents in rabbit atrial and ventricular cells.

    W R Giles;Y Imaizumi

  • Nkx2-5 Pathways and Congenital Heart Disease: Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block

    Mohammad Pashmforoush;Jonathan T Lu;Hanying Chen;Tara St Amand

  • A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of Ito and Confers Susceptibility to Ventricular Tachycardia

    Hai-Chien Kuo;Ching-Feng Cheng;Robert B. Clark;Jim J.-C. Lin

  • Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres.

    R. W. Tsien;W. Giles;P. Greengard

  • A Mathematical Model of Action Potential Heterogeneity in Adult Rat Left Ventricular Myocytes

    Sandeep V. Pandit;Robert B. Clark;Wayne R. Giles;Semahat S. Demir;Semahat S. Demir

  • Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.

    D Fedida;W R Giles

  • An obligatory role for nitric oxide in autonomic control of mammalian heart rate.

    X Han;Y Shimoni;W R Giles

  • A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

    Martin Fink;Carles Callol-Massot;Angela Chu;Pilar Ruiz-Lozano

  • Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements.

    R. A. Bouchard;R. B. Clark;W. R. Giles

  • Heterogeneity of action potential waveforms and potassium currents in rat ventricle

    R B Clark;R A Bouchard;E Salinas-Stefanon;J Sanchez-Chapula

  • Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

    C A Ward;W R Giles

  • Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop

    Barry London;Christine Albert;Mark E. Anderson;Wayne R. Giles

  • Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta.

    Bernd Gloss;Susanne U. Trost;Wolfgang F. Bluhm;Eric A. Swanson

  • Natriuretic peptide C receptor signalling in the heart and vasculature.

    Robert A. Rose;Wayne R. Giles

  • A Mathematical Model of Electrotonic Interactions between Ventricular Myocytes and Fibroblasts

    K. Andrew MacCannell;Hojjat Bazzazi;Lisa Chilton;Yoshiyuki Shibukawa

  • Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms.

    D Fedida;A P Braun;W R Giles

Frequent Co-Authors

Luiz Belardinelli
Luiz Belardinelli University of Florida
Denis Noble
Denis Noble University of Oxford
Paul Kubes
Paul Kubes University of Calgary
Kenneth R. Chien
Kenneth R. Chien Karolinska Institute
David M. Roth
David M. Roth University of California San Diego
William L. Ditto
William L. Ditto North Carolina State University
John Ross
John Ross University of California, San Diego
Paul A. Insel
Paul A. Insel University of California, San Diego
Diana M. Stafforini
Diana M. Stafforini Huntsman Cancer Institute
Susan S. Taylor
Susan S. Taylor University of California, San Diego

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