World's Best Scientists 2026 revealed!
Michael Brudno

Michael Brudno

D-Index & Metrics

Computer Science

D-Index
56
Citations
26716
World Ranking
3944
National Ranking
149

Genetics

D-Index
71
Citations
32608
World Ranking
2153
National Ranking
71

Research.com Recognitions

  • 2010 - Fellow of Alfred P. Sloan Foundation

Overview

Michael Brudno is affiliated with the University of Toronto in Canada. Their research focuses extensively on the intersection of genomics, genetics, and molecular biology, with notable contributions in medicine. Their work covers a variety of subfields, including molecular biology, genetics, cancer research, artificial intelligence, and infectious diseases.

The scientist has published research addressing key topics such as genomics and rare diseases, cancer genomics and diagnostics, ethics in clinical research, SARS-CoV-2 and COVID-19 research, artificial intelligence applications in healthcare and education, liver disease diagnosis and treatment, and genomic variations and chromosomal abnormalities.

Frequent coauthors in their work include Arun Ramani, Andrei L. Turinsky, Mia Husić, Pouria Mashouri, and Kym M. Boycott. Their collaborative efforts extend across various research projects and publications.

Major venues for their publications include bioRxiv (Cold Spring Harbor Laboratory), Genetics in Medicine, Cell Genomics, The American Journal of Human Genetics, and npj Digital Medicine. These venues have featured multiple works by the scientist, reflecting their active engagement in both preprint and peer-reviewed forums.

Recent papers authored or coauthored by Michael Brudno include:

  • GA4GH: International policies and standards for data sharing across genomic research and healthcare, 2021, Cell Genomics
  • Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center, 2020, Gastroenterology
  • DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes, 2020, The American Journal of Human Genetics
  • Splicing is an alternate oncogenic pathway activation mechanism in glioma, 2022, Nature Communications
  • Artificial intelligence applied to 'omics data in liver disease: towards a personalised approach for diagnosis, prognosis and treatment, 2024, Gut

Michael Brudno was awarded the Fellow of Alfred P. Sloan Foundation in 2010, recognizing their role within the scientific community.

Best Publications

  • The ENCODE (ENCyclopedia of DNA elements) Project

    E. A. Feingold;P. J. Good;M. S. Guyer;S. Kamholz

  • The genetic landscape of a cell.

    Michael Costanzo;Anastasia Baryshnikova;Jeremy Bellay;Yungil Kim

  • Genome sequence of the Brown Norway rat yields insights into mammalian evolution

    Richard A. Gibbs;George M. Weinstock;Michael L. Metzker;Donna M. Muzny

  • Similarity network fusion for aggregating data types on a genomic scale

    Bo Wang;Aziz M Mezlini;Feyyaz Demir;Marc Fiume

  • ProbCons: Probabilistic consistency-based multiple sequence alignment

    Chuong B. Do;Mahathi S.P. Mahabhashyam;Michael Brudno;Serafim Batzoglou

  • LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA.

    Michael Brudno;Chuong B. Do;Gregory M. Cooper;Michael F. Kim

  • VISTA : visualizing global DNA sequence alignments of arbitrary length.

    Chris Mayor;Michael Brudno;Jody R. Schwartz;Alexander Poliakov

  • The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

    Sebastian Köhler;Sandra C. Doelken;Christopher J. Mungall;Sebastian Bauer

  • The Human Phenotype Ontology in 2017

    Sebastian Köhler;Nicole A. Vasilevsky;Mark Engelstad;Erin D. Foster

  • SHRiMP: Accurate Mapping of Short Color-space Reads

    Stephen M. Rumble;Phil Lacroute;Adrian V. Dalca;Marc Fiume

  • Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

    Sebastian Köhler;Leigh Carmody;Nicole A. Vasilevsky;Julius O. B. Jacobsen

  • Computational methods for discovering structural variation with next-generation sequencing

    Paul Medvedev;Monica Stanciu;Michael Brudno

  • Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

    Pawel Buczkowicz;Christine Hoeman;Patricia Rakopoulos;Sanja Pajovic

  • Glocal alignment: finding rearrangements during alignment

    Michael Brudno;Sanket Malde;Alexander Poliakov;Chuong B. Do

  • SnowFlock: rapid virtual machine cloning for cloud computing

    Horacio Andrés Lagar-Cavilla;Joseph Andrew Whitney;Adin Matthew Scannell;Philip Patchin

  • The Matchmaker Exchange: a platform for rare disease gene discovery

    Anthony A. Philippakis;Anthony A. Philippakis;Anthony A. Philippakis;Danielle R. Azzariti;Sergi Beltran;Anthony J. Brookes

  • Conservation of core gene expression in vertebrate tissues

    Esther T Chan;Gerald T Quon;Gordon Chua;Gordon Chua;Tomas Babak

  • International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases.

    Kym M. Boycott;Ana Rath;Jessica X. Chong;Taila Hartley

  • SHRiMP2: Sensitive yet Practical Short Read Mapping

    Matei David;Misko Dzamba;Dan Lister;Lucian Ilie

  • Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

    Inna Dubchak;Michael Brudno;Gabriela G. Loots;Lior Pachter

Frequent Co-Authors

Inna Dubchak
Inna Dubchak Lawrence Berkeley National Laboratory
Serafim Batzoglou
Serafim Batzoglou Stanford University
Rosanna Weksberg
Rosanna Weksberg University of Toronto
Cynthia Hawkins
Cynthia Hawkins University of Toronto
Peter N. Robinson
Peter N. Robinson The Jackson Laboratory
Stephen W. Scherer
Stephen W. Scherer University of Toronto
Edward M. Rubin
Edward M. Rubin Joint Genome Institute
Kym M. Boycott
Kym M. Boycott Children's Hospital of Eastern Ontario
Arend Sidow
Arend Sidow Stanford University
David Chitayat
David Chitayat University of Toronto

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