World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
14537
World Ranking
13028
National Ranking
5553

Overview

Yun-Cai Liu is affiliated with the La Jolla Institute for Allergy & Immunology in the United States. Their research spans multiple areas within immunology, molecular biology, and insect science, with a significant focus on immune cell function and insect biology.

The scientist has published work in various notable venues, including:

  • Cell Research
  • The Journal of Experimental Medicine
  • PLoS Genetics
  • International Journal of Biological Macromolecules
  • Scientific Reports

The main fields of study for Yun-Cai Liu include Immunology and Microbiology, Agricultural and Biological Sciences, and Biochemistry, Genetics and Molecular Biology. Subfields within these areas where the scientist has contributed are Immunology, Insect Science, Molecular Biology, Genetics, and Infectious Diseases.

Their work covers several research topics such as:

  • Insect and Pesticide Research
  • Immune Cell Function and Interaction
  • Insect and Arachnid Ecology and Behavior
  • Heat shock proteins research
  • Insect-Plant Interactions and Control
  • Interferon and immune responses
  • Inflammasome and immune disorders

Yun-Cai Liu has collaborated frequently with several co-authors, including Jing Bai, Yucheng Wang, Wei-Rong Gong, Yu-Zhou Du, and Ji-Hye Han. These collaborations have produced research spanning both insect biology and immune system studies.

Some of their recent publications include:

  • Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy, 2020, Cell Research
  • Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity, 2022, The Journal of Experimental Medicine
  • Imaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori, 2020, PLoS Genetics
  • Isolation of two new genes encoding heat shock protein 70 in Bemisia tabaci and analysis during thermal stress, 2021, International Journal of Biological Macromolecules
  • Knockdown of heat shock transcription factor 1 decreases temperature stress tolerance in Bemisia tabaci MED, 2022, Scientific Reports

Best Publications

  • The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

    Claudio A. P. Joazeiro;Simon S. Wing;Han-kuei Huang;Joel D. Leverson

  • Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

    Vigo Heissmeyer;Fernando Macián;Fernando Macián;Sin Hyeog Im;Sin Hyeog Im;Rajat Varma

  • Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

    Mengze Lv;Mengze Lv;Meixia Chen;Rui Zhang;Wen Zhang;Wen Zhang

  • Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

    Deyu Fang;Chris Elly;Baixue Gao;Nan Fang

  • Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

    Min Gao;Tord Labuda;Tord Labuda;Tord Labuda;Ying Xia;Ying Xia;Ying Xia;Ewen Gallagher;Ewen Gallagher;Ewen Gallagher

  • Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.

    Ling Qiu;Claudio Joazeiro;Nan Fang;Hong-Ying Wang

  • Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction

    Myung Shin Jeon;Alex Atfield;Alex Atfield;K. Venuprasad;Connie Krawczyk

  • Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.

    Bingcheng Wang;Hongzhu Yang;Yun Cai Liu;Tomas Jelinek

  • The ubiquitin-protein ligase Itch regulates p73 stability

    Mario Rossi;Mario Rossi;Vincenzo De Laurenzi;Vincenzo De Laurenzi;Eliana Munarriz;Douglas R. Green

  • Ubiquitin ligases and the immune response.

    Yun-Cai Liu

  • Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.

    Toshifumi Mikayama;Tatsumi Nakano;Hideho Gomi;Yukimitsu Nakagawa

  • Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

    Ewen Gallagher;Min Gao;Yun-Cai Liu;Michael Karin

  • Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

    You Wei Zhang;Diane M. Otterness;Gary G. Chiang;Weilin Xie

  • Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

    Yohsuke Harada;Yasuyo Harada;Chris Elly;Ge Ying

  • Immunity by ubiquitylation: a reversible process of modification

    Yun-Cai Liu;Josef Penninger;Michael Karin

  • Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

    Deyu Fang;Hong Ying Wang;Nan Fang;Yoav Altman

  • The Tight Junction-specific Protein Occludin Is a Functional Target of the E3 Ubiquitin-protein Ligase Itch

    Andreas Traweger;Deyu Fang;Yun Cai Liu;Wolfgang Stelzhammer

  • The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

    K. Venuprasad;Haining Huang;Yousuke Harada;Chris Elly

  • K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling

    Haining Huang;Myung-shin Jeon;Lujian Liao;Chun Yang

  • Proteolysis-independent regulation of PI3K by Cbl-bmediated ubiquitination in T cells

    Deyu Fang;Yun-Cai Liu

Frequent Co-Authors

Amnon Altman
Amnon Altman La Jolla Institute For Allergy & Immunology
Deyu Fang
Deyu Fang Northwestern University
Michael Karin
Michael Karin University of California, San Diego
Shane Crotty
Shane Crotty La Jolla Institute For Allergy & Immunology
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Josef M. Penninger
Josef M. Penninger University of British Columbia
John R. Yates
John R. Yates Scripps Research Institute
Wallace Y. Langdon
Wallace Y. Langdon University of Western Australia
Gottfried Baier
Gottfried Baier Innsbruck Medical University
Mitchell Kronenberg
Mitchell Kronenberg University of California, San Diego

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