World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
16535
World Ranking
7787
National Ranking
3544

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors
  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2005 - Fellow of Alfred P. Sloan Foundation

Overview

Paul J. Hergenrother is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, materials chemistry, oncology, genetics, and molecular medicine.

The scientist's work encompasses several primary topics including:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Antibiotic Resistance in Bacteria
  • Bacterial Genetics and Biotechnology
  • Cancer Therapeutics and Mechanisms
  • Microbial Natural Products and Biosynthesis
  • Endoplasmic Reticulum Stress and Disease

Among the frequent publication venues for this researcher are:

  • Cancer Research (15 publications)
  • The Cambridge Structural Database (14 publications)
  • Journal of the Endocrine Society (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Journal of the American Chemical Society (5 publications)

Frequent collaborators in their research include:

  • Matthew W. Boudreau
  • Timothy M. Fan
  • Emily J. Tonogai
  • David J. Shapiro
  • Erik R. Nelson

Representative recent papers authored or co-authored by Paul J. Hergenrother include:

  • "A Gram-negative-selective antibiotic that spares the gut microbiome," 2024, published in Nature
  • "Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury," 2021, published in Nature Communications
  • "Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria," 2021, published in Accounts of Chemical Research
  • "Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch," 2020, published in Journal of the American Chemical Society

Paul J. Hergenrother has received recognition in the form of several fellowships, including:

  • Fellow, National Academy of Inventors (2020)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2019)
  • Fellow of Alfred P. Sloan Foundation (2005)

Their work consistently integrates molecular and chemical biology techniques to address topics such as antibiotic resistance and cancer biology. The substantial number of publications in both biochemistry and medicine reflects a multifaceted approach bridging fundamental science and translational research.

Best Publications

  • How many human proteoforms are there

    Ruedi Aebersold;Jeffrey N. Agar;I. Jonathan Amster;Mark S. Baker

  • Predictive compound accumulation rules yield a broad-spectrum antibiotic

    Michelle F. Richter;Bryon S. Drown;Andrew P. Riley;Alfredo Garcia

  • DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action.

    Rahul Palchaudhuri;Paul J Hergenrother

  • Targeting RNA with small molecules

    Jason R. Thomas;Paul J. Hergenrother

  • Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays

    Finny G. Kuruvilla;Alykhan F. Shamji;Alykhan F. Shamji;Scott M. Sternson;Scott M. Sternson;Paul J. Hergenrother;Paul J. Hergenrother;Paul J. Hergenrother

  • Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

    Karson S. Putt;Grace W. Chen;Jennifer M. Pearson;Joseph S. Sandhorst

  • Glucose conjugation for the specific targeting and treatment of cancer

    Emilia C. Calvaresi;Paul J. Hergenrother

  • Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol-Containing Small Molecules on Glass Slides

    Paul J. Hergenrother;Kristopher M. Depew;Stuart L. Schreiber

  • Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

    Carlotta Granchi;Sarabindu Roy;Chiara Giacomelli;Marco Macchia

  • Iron Salts Perturb Biofilm Formation and Disrupt Existing Biofilms of Pseudomonas aeruginosa

    Dinty J. Musk;David A. Banko;Paul J. Hergenrother

  • Chemical countermeasures for the control of bacterial biofilms: effective compounds and promising targets.

    Dinty J. Musk;Paul J. Hergenrother

  • Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

    Evijola Llabani;Robert W. Hicklin;Hyang Yeon Lee;Stephen E. Motika

  • Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.

    Wulf Tonnus;Claudia Meyer;Christian Steinebach;Alexia Belavgeni

  • The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics.

    Michelle F. Richter;Paul J. Hergenrother

  • Natural products as starting points for the synthesis of complex and diverse compounds

    Karen C. Morrison;Paul J. Hergenrother

  • Size-specific ligands for RNA hairpin loops

    Jason R Thomas;Xianjun Liu;Paul J Hergenrother;Paul J Hergenrother

  • An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors

    Karson S Putt;Paul J Hergenrother

  • PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

    Quinn P. Peterson;David R. Goode;Diana C. West;Kara N. Ramsey

  • Poly(ADP-ribose) makes a date with death

    James T Heeres;Paul J Hergenrother

  • Identification of the cellular targets of bioactive small organic molecules using affinity reagents

    Benjamin J. Leslie;Paul J. Hergenrother

Frequent Co-Authors

Stephen F. Martin
Stephen F. Martin The University of Texas at Austin
Brian T. Cunningham
Brian T. Cunningham University of Illinois at Urbana-Champaign
David J. Shapiro
David J. Shapiro University of Illinois at Urbana-Champaign
David A. Boothman
David A. Boothman Indiana University
Tiziano Tuccinardi
Tiziano Tuccinardi University of Pisa
Taekjip Ha
Taekjip Ha Johns Hopkins University
Ivan Ahel
Ivan Ahel University of Oxford
Elizabeth M. Wilson
Elizabeth M. Wilson University of North Carolina at Chapel Hill
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai

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