2026 David J. Shapiro: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	59	12802	11781	5455	4882	154	9831

Overview

David J. Shapiro is a researcher affiliated with the University of Illinois at Urbana-Champaign in the United States. Their work primarily focuses on areas within biochemistry, genetics, molecular biology, and medicine, with a significant emphasis on molecular biology, genetics, cell biology, oncology, and cancer research.

The scientist has contributed to several notable research topics including:

Estrogen and related hormone effects
Endoplasmic reticulum stress and disease
Cholesterol and lipid metabolism
Cancer, lipids, and metabolism
Cancer, hypoxia, and metabolism
Advanced breast cancer therapies
Ferroptosis and cancer prognosis

Frequent publication venues for their work include:

Cancer Research
Journal of the Endocrine Society
UNC Libraries
Cancer Letters
Cancer Immunology Research

Recent research papers authored or co-authored by David J. Shapiro comprise:

"27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression" (2020, Cancer Letters)
"First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure" (2024, Cell)
"A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice" (2021, Science Translational Medicine)
"Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis" (2023, Cancer Research)
"Targeting Metabolic Adaptations in the Breast Cancer-Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy" (2022, Molecular Cancer Research)

David J. Shapiro has collaborated frequently with a number of researchers, including:

Paul J. Hergenrother
Erik R. Nelson
Matthew W. Boudreau
Chengjian Mao
Darjan Duraki

Best Publications

A high-efficiency HeLa cell nuclear transcription extract.

David J. Shapiro;Phillip A. Sharp;Walter W. Wahli;Martha J. Keller

706
Citations
Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation

Martin L. Brock;David J. Shapiro

599
Citations
Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis.

David J. Shapiro;Victor W. Rodwell

331
Citations
The immune system and inflammation in breast cancer.

Xinguo Jiang;David J. Shapiro

246
Citations
3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells

Gilbert-A. Keller;Michelle C. Barton;David J. Shapiro;S. J. Singer

222
Citations
The Xenopus laevis estrogen receptor: sequence homology with human and avian receptors and identification of multiple estrogen receptor messenger ribonucleic acids.

Ivan Jeanne Weiler;Denise Lew;David J. Shapiro

216
Citations
Insights into hormonal control of messenger RNA stability.

David A. Nielsen;David J. Shapiro

210
Citations
Preparation of capped RNA transcripts using T7 RNA polymerase

David A. Nielsen;David J. Shapiro

208
Citations
Regulation of messenger RNA stability in eukaryotic cells

David J. Shapiro;John E. Blume;David A. Nielsen

171
Citations
Powerful dominant negative mutants of the human estrogen receptor.

B. A. Ince;Yao Zhuang;C. K. Wrenn;D. J. Shapiro

170
Citations
Kinetics of estrogen induction of Xenopus laevis vitellogenin messenger RNA as measured by hybridization to complementary DNA.

H. J. Baker;David J. Shapiro

168
Citations
Influence of whole body protein turnover rate on resting energy expenditure in patients with cancer.

Kenneth C. H. Fearon;Douglas T. Hansell;Thomas Preston;Jane A. Plumb

158
Citations
A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells

David A. Nielsen;Tsu Chung Chang;David J. Shapiro

158
Citations
Vigilin, a ubiquitous protein with 14 K homology domains, is the estrogen-inducible vitellogenin mRNA 3'-untranslated region-binding protein.

Robin E. Dodson;David J. Shapiro

149
Citations
Anticipatory Estrogen Activation of the Unfolded Protein Response is Linked to Cell Proliferation and Poor Survival in Estrogen Receptor α Positive Breast Cancer

Neal Andruska;Xiaobin Zheng;Xujuan Yang;William G. Helferich

138
Citations
Estrogen regulates the absolute rate of transcription of the Xenopus laevis vitellogenin genes.

M. L. Brock;David J. Shapiro

137
Citations
A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

Lily Mahapatra;Neal Andruska;Chengjian Mao;Jeremy Le

135
Citations
Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death

Maria Obrero;David V. Yu;David J. Shapiro

134
Citations
HMG-1 stimulates estrogen response element binding by estrogen receptor from stably transfected HeLa cells.

Cheng Cheng Zhang;Sacha Krieg;David J. Shapiro

134
Citations
Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis.

Cheng Cheng Zhang;David J. Shapiro

129
Citations