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Medicine

D-Index
102
Citations
34534
World Ranking
7724
National Ranking
4018

Overview

Francis G. Spinale is affiliated with the University of South Carolina in the United States. Their research work is concentrated primarily in the field of Medicine, with a significant focus on Cardiology and Cardiovascular Medicine, Surgery, Oncology, Molecular Biology, and Pulmonary and Respiratory Medicine.

The scientist's scholarly output includes a substantial number of publications addressing cardiovascular and related biomedical topics. Their work covers a variety of specialized topics such as:

  • Cardiovascular Function and Risk Factors
  • Cardiac Fibrosis and Remodeling
  • Peptidase Inhibition and Analysis
  • Cardiac Structural Anomalies and Repair
  • Cardiovascular Disease and Adiposity
  • Tissue Engineering and Regenerative Medicine
  • Stress Responses and Cortisol

Among the notable recent papers co-authored by Spinale are:

  • Guidelines for in vivo mouse models of myocardial infarction, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity, 2020, JACC CardioOncology
  • Reperfused vs. nonreperfused myocardial infarction: when to use which model, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Changes in Myocardial Microstructure and Mechanics With Progressive Left Ventricular Pressure Overload, 2020, JACC Basic to Translational Science
  • Ensemble machine learning model identifies patients with HFpEF from matrix-related plasma biomarkers, 2022, American Journal of Physiology-Heart and Circulatory Physiology

Frequent venues where Spinale has published include:

  • Circulation
  • Physiology
  • American Journal of Physiology-Heart and Circulatory Physiology
  • JACC Basic to Translational Science
  • Zenodo (CERN European Organization for Nuclear Research)

Collaboration is a significant aspect of Spinale's scientific activity. Some of their frequent co-authors include Lisa Freeburg, Tarek Shazly, Albert J. Sinusas, Amelia Churillo, and Shayne C. Barlow.

Best Publications

  • Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

    Francis G. Spinale

  • Pathophysiologically relevant concentrations of tumor necrosis factor- α promote progressive left ventricular dysfunction and remodeling in rats

    Biykem Bozkurt;Scott B. Kribbs;Fred J. Clubb;Lloyd H. Michael

  • Matrix Metalloproteinases: Regulation and Dysregulation in the Failing Heart

    Francis G. Spinale

  • A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure

    Francis G. Spinale;Mytsi L. Coker;Lena J. Heung;Brian R. Bond

  • Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.

    Chadwick V. Thomas;Mytsi L. Coker;James L. Zellner;John R. Handy

  • Time-Dependent Changes in Matrix Metalloproteinase Activity and Expression During the Progression of Congestive Heart Failure: Relation to Ventricular and Myocyte Function

    Francis G. Spinale;Mytsi L. Coker;Chadwick V. Thomas;Jennifer D. Walker

  • Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases: Relationship Between Changes in Proteolytic Determinants of Matrix Composition and Structural, Functional, and Clinical Manifestations of Hypertensive Heart Disease

    S. Hinan Ahmed;Leslie L. Clark;Weems R. Pennington;Carson S. Webb

  • Primary Results From the SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods Used in Cardiac Resynchronization Therapy (SMART-AV) Trial A Randomized Trial Comparing Empirical, Echocardiography-Guided, and Algorithmic Atrioventricular Delay Programming in Cardiac Resynchronization Therapy

    Kenneth A. Ellenbogen;Michael R. Gold;Timothy E. Meyer;Ignacio Fernández Lozano

  • Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

    Natarajan Sivasubramanian;Mytsi L. Coker;Karla M. Kurrelmeyer;William R. MacLellan

  • Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure Effects on Left Ventricular Dimensions and Function

    Francis G. Spinale;Mytsi L. Coker;Stephen R. Krombach;Rupak Mukherjee

  • Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

    Brendan P. Purcell;David Lobb;Manoj B. Charati;Shauna M. Dorsey

  • Animal Models of Heart Failure A Scientific Statement From the American Heart Association

    Steven R. Houser;Kenneth B. Margulies;Anne M. Murphy;Francis G. Spinale

  • Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure

    J. Thomas Peterson;Hussein Hallak;Linda Johnson;Hua Li

  • Large Animal Models of Heart Failure A Critical Link in the Translation of Basic Science to Clinical Practice

    Jennifer A. Dixon;Francis G. Spinale

  • Arrhythmia-Induced Cardiomyopathies: Mechanisms, Recognition, and Management

    Rakesh Gopinathannair;Susan P. Etheridge;Francis E. Marchlinski;Francis G. Spinale

  • Myocardial Infarct Expansion and Matrix Metalloproteinase Inhibition

    Rupak Mukherjee;Theresa A. Brinsa;Kathryn B. Dowdy;Amelia A. Scott

  • Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target

    Francis G Spinale;Mytsi L Coker;Brian R Bond;James L Zellner

  • Specific Temporal Profile of Matrix Metalloproteinase Release Occurs in Patients After Myocardial Infarction Relation to Left Ventricular Remodeling

    Carson S. Webb;David D. Bonnema;S. Hinan Ahmed;Amy H. Leonardi

  • Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart

    Guangwu Wang;Tariq Hamid;Rachel J. Keith;Guihua Zhou

  • Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling

    Eric M. Wilson;Sina L. Moainie;Julia M. Baskin;Abigail S. Lowry

Frequent Co-Authors

Michael R. Zile
Michael R. Zile Medical University of South Carolina
Scott Reeves
Scott Reeves St George's, University of London
Joseph H. Gorman
Joseph H. Gorman University of Pennsylvania
Robert C. Gorman
Robert C. Gorman University of Pennsylvania
Merry L. Lindsey
Merry L. Lindsey University of Nebraska Medical Center
Blase A. Carabello
Blase A. Carabello Baylor College of Medicine
Jason A. Burdick
Jason A. Burdick University of Colorado Boulder
Douglas L. Mann
Douglas L. Mann Washington University in St. Louis
Michael R. Gold
Michael R. Gold Medical University of South Carolina
Joseph E. Bavaria
Joseph E. Bavaria University of Pennsylvania

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