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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
15701
World Ranking
6061
National Ranking
2853

Overview

Shiuan Chen is affiliated with the City Of Hope National Medical Center in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research portfolio spans several subfields, notably molecular biology, genetics, oncology, cancer research, and pulmonary and respiratory medicine.

Their work often focuses on topics including estrogen and related hormone effects, cancer cells and metastasis, single-cell and spatial transcriptomics, breast cancer treatment studies, advanced breast cancer therapies, HER2/EGFR in cancer research, and fungal biology and applications.

Shiuan Chen has published numerous papers, with recent examples including:

  • Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis, 2021, Communications Biology
  • Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts, 2021, International Journal of Molecular Sciences
  • Role of the mitochondrial stress response in human cancer progression, 2020, Experimental Biology and Medicine
  • White button mushroom (Agaricus bisporus) disrupts androgen receptor signaling in human prostate cancer cells and patient-derived xenograft, 2020, The Journal of Nutritional Biochemistry
  • Evaluation of a Keratin 1 Targeting Peptide-Doxorubicin Conjugate in a Mouse Model of Triple-Negative Breast Cancer, 2021, Pharmaceutics

Frequently collaborating with a core group of researchers, Shiuan Chen's coauthors include Kohei Saeki, Xiaoqiang Wang, Xiwei Wu, Gregory Chang, and Desiree Ha. These collaborations reflect a substantial network that supports interdisciplinary and focused cancer research.

Chen's research has appeared in a variety of publication venues, with multiple contributions to Cancer Research, Zenodo, Journal of the Endocrine Society, Cancers, and Research Square, representing a broad engagement with both specialized and open-access platforms.

Best Publications

  • Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer

    Anne Boulay;Joelle Rudloff;Jingjing Ye;Sabine Zumstein-Mecker

  • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

    Yeh-Chih Kao;Changbao Zhou;Mark Sherman;Charles A. Laughton

  • CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells

    Akihiro Tsuyada;Amy Chow;Jun Wu;George Somlo

  • Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.

    Zhibo Yang;Suresh Rayala;Diep Nguyen;Ratna K. Vadlamudi

  • Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15.

    Shiuan Chen;Marc J. Besman;Robert S. Sparkes;Susan Zollman

  • Stable Expression of Human Aromatase Complementary DNA in Mammalian Cells: A Useful System for Aromatase Inhibitor Screening

    Dujin Zhou;Denis Pompon;Shiuan Chen

  • Hormonal regulation, tissue distribution, and content of aromatase cytochrome P450 messenger ribonucleic acid and enzyme in rat ovarian follicles and corpora lutea: relationship to estradiol biosynthesis.

    Gerard J. Hickey;Shiuan Chen;Marc J. Besman;John E. Shively

  • Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway

    Lynn S. Adams;Sheryl Phung;Natalie Yee;Navindra P. Seeram

  • Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro.

    Lynn S. Adams;Yanjun Zhang;Navindra P. Seeram;David Heber

  • Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors.

    Masatomo Suetsugi;Leila Su;Kimberly Karlsberg;Yate-Ching Yuan

  • Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release.

    Margarita Faig;Mario Antonio Bianchet;Paul Talalay;Shiuan Chen

  • Curvature as a determinant of microstructure and microemulsions

    S. J. Chen;D. F. Evans;B. W. Ninham;D. J. Mitchell

  • A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene.

    Wei Yue;Dujin Zhou;Shiuan Chen;Angela Brodie

  • Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus)

    Shiuan Chen;Sei-Ryang Oh;Sheryl Phung;Gene Hur

  • White Button Mushroom Phytochemicals Inhibit Aromatase Activity and Breast Cancer Cell Proliferation

    Baiba J Grube;Elizabeth T. Eng;Yeh-Chih Kao;Annette Kwon

  • Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction.

    Changbao Zhou;Dujin Zhou;Jose Esteban;James Murai

  • Modulation of Aromatase Expression in the Breast Tissue by ERRα-1 Orphan Receptor

    Chun Yang;Dujin Zhou;Shiuan Chen

  • Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells.

    Liya Li;Lynn S. Adams;Shiuan Chen;Caroline Killian

  • The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.

    Yun Wang;Kai Woo Lee;Franky L. Chan;Shiuan Chen

  • DT-DIAPHORASE : REDOX POTENTIAL, STEADY-STATE, AND RAPID REACTION STUDIES

    Gabriella Tedeschi;Shiuan Chen;Vincent Massey

Frequent Co-Authors

Xiwei Wu
Xiwei Wu City Of Hope National Medical Center
George Somlo
George Somlo City Of Hope National Medical Center
John E. Shively
John E. Shively City Of Hope National Medical Center
Susan L. Neuhausen
Susan L. Neuhausen City Of Hope National Medical Center
Charles A. Laughton
Charles A. Laughton University of Nottingham
Youssef Hatefi
Youssef Hatefi Scripps Research Institute
Ratna K. Vadlamudi
Ratna K. Vadlamudi The University of Texas at Austin
Barry W. Ninham
Barry W. Ninham Australian National University
Vincent Massey
Vincent Massey University of Michigan–Ann Arbor
Menghang Xia
Menghang Xia National Institutes of Health

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