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Floris P. J. G. Lafeber

Floris P. J. G. Lafeber

Overview

Floris P. J. G. Lafeber is affiliated with Utrecht University in the Netherlands and has contributed extensively to the field of medical research, with a primary focus on rheumatology and related subfields. Their research work encompasses a broad range of topics mainly centered on osteoarthritis and rheumatoid arthritis, as well as surgical outcomes and hematology.

The scientist's main fields of study include:

  • Medicine

Within this domain, Lafeber's research contributions can be categorized into several subfields, including:

  • Rheumatology
  • Surgery
  • Hematology
  • Genetics
  • Pathology and Forensic Medicine

The primary research topics addressed by Lafeber include:

  • Osteoarthritis Treatment and Mechanisms
  • Rheumatoid Arthritis Research and Therapies
  • Total Knee Arthroplasty Outcomes
  • Knee injuries and reconstruction techniques
  • Hemophilia Treatment and Research
  • Lymphoma Diagnosis and Treatment
  • Systemic Lupus Erythematosus Research

Lafeber has published numerous scholarly articles, some of the recent papers being:

  • "Difficult-to-treat rheumatoid arthritis: contributing factors and burden of disease," 2020, Lara D. Veeken
  • "Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain," 2021, Journal of Neuroscience
  • "Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers," 2020, BMJ Open
  • "Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data," 2020, PLoS ONE
  • "Healthcare utilization and economic burden of difficult-to-treat rheumatoid arthritis: a cost-of-illness study," 2021, Lara D. Veeken

The venues where Lafeber frequently publishes their work include:

  • Lara D. Veeken
  • Haemophilia
  • PLoS ONE
  • RMD Open
  • BMJ Open

Collaboration is also a significant aspect of Lafeber's academic output. Frequent co-authors include:

  • S.C. Mastbergen
  • Paco M J Welsing
  • Mylène P. Jansen
  • Janneke Tekstra
  • M. Kloppenburg

Best Publications

  • Osteoarthritis: an update with relevance for clinical practice

    Johannes W J Bijlsma;Francis Berenbaum;Floris P J G Lafeber

  • Effect of collagen turnover on the accumulation of advanced glycation end products.

    Nicole Verzijl;Jeroen DeGroot;Suzanne R. Thorpe;Ruud A. Bank

  • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid.

    Jocea M. R. van Amelsfort;Kim M. G. Jacobs;Johannes W. J. Bijlsma;Floris P. J. G. Lafeber

  • Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis

    Nicole Verzijl;Jeroen DeGroot;Chaya Ben Zaken;Orit Braun-Benjamin

  • Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage.

    Ruud A. Bank;Michael T. Bayliss;Floris P. J. G. Lafeber;Alice Maroudas

  • Age-related accumulation of Maillard reaction products in human articular cartilage collagen.

    Nicole Verzijl;Jeroen Degroot;Esther Oldehinkel;Ruud A. Bank

  • Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial.

    Marije F. Bakker;Johannes W.G. Jacobs;Paco M.J. Welsing;Suzanne M.M. Verstappen

  • Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells

    Leonie S. Taams;Jocea M.R. van Amelsfort;Machteld M. Tiemessen;Kim M.G. Jacobs

  • Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

    Leonie S. Taams;Milica Vukmanovic-Stejic;Jay Smith;Padraic J. Dunne

  • Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis

    Jeroen DeGroot;Nicole Verzijl;Marion J. G. Wenting-Van Wijk;Kim M. G. Jacobs

  • Proinflammatory mediator–induced reversal of CD4+,CD25+ regulatory T cell–mediated suppression in rheumatoid arthritis

    Jocea M. R. van Amelsfort;Joel A. G. van Roon;Madelon Noordegraaf;Kim M. G. Jacobs

  • Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early) : a multicentre, randomised, double-blind, double-dummy, strategy trial

    Johannes W J Bijlsma;Paco M J Welsing;Thasia G Woodworth;Leonie M Middelink

  • Comprehensive LC−MSE Lipidomic Analysis using a Shotgun Approach and Its Application to Biomarker Detection and Identification in Osteoarthritis Patients

    Jose M. Castro-Perez;Jurre Kamphorst;Jeroen DeGroot;Floris Lafeber

  • A simplified measurement of degraded collagen in tissues: Application in healthy, fibrillated and osteoarthritic cartilage

    R.A. Bank;M. Krikken;B. Beekman;R. Stoop

  • Short-Term Exposure of Cartilage to Blood Results in Chondrocyte Apoptosis

    Michel Hooiveld;Goris Roosendaal;Marion Wenting;Marijke van den Berg

  • Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.

    Peter L. E. M. van Lent;Arjen B. Blom;Rik F. P. Schelbergen;Annet Slöetjes

  • Age-related decrease in proteoglycan synthesis of human articular chondrocytes: The role of nonenzymatic glycation

    Jeroen DeGroot;Nicole Verzijl;Ruud A. Bank;Floris P. J. G. Lafeber

  • Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis.

    Joel A. G. van Roon;Floris P. J. G. Lafeber;J. W. J. Bijlsma

  • Physiopathology of haemophilic arthropathy.

    F. P. J. G. Lafeber;P. Miossec;L. A. Valentino

  • Clinical benefit of joint distraction in the treatment of severe osteoarthritis of the ankle: Proof of concept in an open prospective study and in a randomized controlled study

    Anne C. A. Marijnissen;Peter M. Van Roermund;Jan Van Melkebeek;Willem Schenk

Frequent Co-Authors

Johannes W. J. Bijlsma
Johannes W. J. Bijlsma Utrecht University
Joel A G van Roon
Joel A G van Roon University Medical Center Utrecht
Jeroen DeGroot
Jeroen DeGroot Charles River Laboratories (Netherlands)
Harrie Weinans
Harrie Weinans Utrecht University
Ruud A. Bank
Ruud A. Bank University Medical Center Groningen
Johan M. TeKoppele
Johan M. TeKoppele Utrecht University
Max A. Viergever
Max A. Viergever Utrecht University
Timothy R D J Radstake
Timothy R D J Radstake Utrecht University
Thomas Hankemeier
Thomas Hankemeier Leiden University
Ali Mobasheri
Ali Mobasheri University of Oulu

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