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Biology and Biochemistry

D-Index
55
Citations
10810
World Ranking
15062
National Ranking
6303

Overview

Sachiko Kajigaya is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields with a strong focus on Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Kajigaya's work is concentrated on several subfields including Molecular Biology, Hematology, Immunology, Genetics, and Cancer Research.

The scientist's main research topics include:

  • Single-cell and spatial transcriptomics
  • Acute Myeloid Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Immune Cell Function and Interaction
  • Cancer Genomics and Diagnostics
  • Otitis Media and Relapsing Polychondritis
  • Immunodeficiency and Autoimmune Disorders

Kajigaya has a number of recent publications that reflect these research interests. Some of their notable papers include:

  • Spectrum of clonal hematopoiesis in VEXAS syndrome, 2023, Blood
  • Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells, 2022, Nature Communications
  • Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS, 2023, Cell Reports Medicine
  • Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome, 2020, Haematologica
  • HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia, 2021, Blood

The scientist frequently publishes in the following venues:

  • Blood
  • Nature Communications
  • Haematologica
  • Blood Advances
  • Cell Reports Medicine

Sachiko Kajigaya has collaborated often with several co-authors across their body of work. Frequent co-authors include:

  • Neal S. Young
  • Emma M. Groarke
  • Bhavisha A. Patel
  • Shouguo Gao
  • Zhijie Wu

Best Publications

  • Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.

    Hiroki Yamaguchi;Rodrigo T. Calado;Hinh Ly;Sachiko Kajigaya

  • ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.

    Jianxiang Wang;Taizo Hoshino;Robert L. Redner;Sachiko Kajigaya

  • Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.

    Rodrigo T. Calado;William T. Yewdell;Keisha L. Wilkerson;Joshua A. Regal

  • Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.

    Sachiko Kajigaya;Hiroyuki Fujii;Anne Field;Stacie Anderson

  • Hematopoietic-specific microRNA expression in human cells.

    Shakti H. Ramkissoon;Lori A. Mainwaring;Yoji Ogasawara;Keyvan Keyvanfar

  • Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic anemia

    Elena E. Solomou;Katayoun Rezvani;Stephan Mielke;Daniela Malide

  • The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells.

    K Ozawa;J Ayub;S Kajigaya;T Shimada

  • Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.

    Xingmin Feng;Sachiko Kajigaya;Elena E. Solomou;Keyvan Keyvanfar

  • Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.

    Hitoshi Take;Shinji Watanabe;Kazuyo Takeda;Zu-Xi Yu

  • Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells.

    Yoshiyuki Takahashi;Nanae Harashima;Sachiko Kajigaya;Hisayuki Yokoyama

  • Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities

    Guibin Chen;Weihua Zeng;Akira Miyazato;Eric Billings

  • Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions.

    T Saikawa;S Anderson;M Momoeda;S Kajigaya

  • SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase *

    Ken-ichi Ohya;Sachiko Kajigaya;Yoshihiro Yamashita;Akira Miyazato

  • The Structure of Human Parvovirus B19 at 8 Å; Resolution

    Mavis Agbandje;Sachiko Kajigaya;Robert McKenna;Neal S. Young

  • Candidate Recombinant Vaccine for Human B19 Parvovirus

    Geetha P. Bansal;Jacqueline A. Hatfield;Frances E. Dunn;Andrew A. Kramer

  • First continuous propagation of B19 parvovirus in a cell line

    Satoshi Shimomura;Norio Komatsu;Norbert Frickhofen;Stacie Anderson

  • The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage.

    Makoto Futaki;Takehito Igarashi;Shinji Watanabe;Sachiko Kajigaya

  • Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor

    Paul R. Chipman;Mavis Agbandje-McKenna;Sachiko Kajigaya;Kevin E. Brown

  • Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor

    Elaine M. Sloand;Agnes S. M. Yong;Shakti Ramkissoon;Elena Solomou

  • Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface.

    Stephen J. Rosenfeld;Kohji Yoshimoto;Sachiko Kajigaya;Stacie Anderson

Frequent Co-Authors

Neal S. Young
Neal S. Young National Institutes of Health
J. Philip McCoy
J. Philip McCoy National Institutes of Health
A. John Barrett
A. John Barrett National Institutes of Health
Yong-Gang Yao
Yong-Gang Yao Chinese Academy of Sciences
Richard Childs
Richard Childs National Institutes of Health
Taco W. Kuijpers
Taco W. Kuijpers University of Amsterdam
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania
Stacie M. Anderson
Stacie M. Anderson National Institutes of Health
Peter J. Munson
Peter J. Munson Center for Information Technology
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia

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