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Biology and Biochemistry

D-Index
55
Citations
11343
World Ranking
15019
National Ranking
1066

Overview

Klaus-Peter Janssen is affiliated with the Technical University of Munich in Germany. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology.

Their work spans several subfields, including molecular biology, oncology, epidemiology, immunology, and physiology. Janssen's research topics address key areas such as gut microbiota and health, diet and metabolism studies, Helicobacter pylori-related gastroenterology studies, liver disease diagnosis and treatment, immune cell function and interaction, Mycobacterium research and diagnosis, and genetic factors in colorectal cancer.

Janssen has published extensively, with frequent papers appearing in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Gastroenterology, Blood, Zeitschrift für Gastroenterologie, and Signal Transduction and Targeted Therapy.

  • The Colorectal Cancer Lipidome: Identification of a Robust Tumor-Specific Lipid Species Signature, 2021, Gastroenterology
  • Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis, 2023, Journal of Hepatology
  • T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours, 2021, Nature Biomedical Engineering
  • Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature, 2023, Gut
  • Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19, 2022, Gut Microbes

Frequent collaborators of Janssen include Dirk Haller, Katja Steiger, Michael Quante, Josef Ecker, and Klaus Neuhaus, reflecting a broad network of cooperative research efforts.

  • Dirk Haller
  • Katja Steiger
  • Michael Quante
  • Josef Ecker
  • Klaus Neuhaus

Their research places a particular emphasis on the interactions between the gut microbiota and human health, including the mechanisms of microbial influence on cancer development and liver regeneration. The integration of molecular biology and immunology informs their multidisciplinary approach to understanding disease processes and therapeutic strategies.

Janssen's work also explores the role of immune cells in disease contexts, such as the enhancement of adoptive cell therapy for pancreatic tumors and the immune system's response in gastrointestinal cancers.

Best Publications

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Comprehensive Characterization of Cancer Driver Genes and Mutations.

    Matthew H Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

    Benjamin J. Raphael;Ralph H. Hruban;Andrew J. Aguirre;Richard A. Moffitt

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

    André Kahles;Kjong-Van Lehmann;Nora C Toussaint;Matthias Hüser

  • Pathogenic Germline Variants in 10,389 Adult Cancers

    Kuan-Lin Huang;R Jay Mashl;Yige Wu;Deborah I Ritter

  • Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.

    Ping Zhu;Elke Martin;Jörg Mengwasser;Peter Schlag

  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

    Franz X. Schaub;Varsha Dhankani;Ashton C. Berger;Mihir Trivedi

  • Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

    Silvia Fre;S. K. Pallavi;Mathilde Huyghe;Marick Laé

  • Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

    Joshua D. Campbell;Joshua D. Campbell;Joshua D. Campbell;Christina Yau;Christina Yau;Reanne Bowlby;Yuexin Liu

  • APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression

    Klaus–Peter Janssen;Klaus–Peter Janssen;Paola Alberici;Hafida Fsihi;Claudia Gaspar

  • Fascin, a Novel Target of β-Catenin-TCF Signaling, Is Expressed at the Invasive Front of Human Colon Cancer

    Danijela Vignjevic;Marie Schoumacher;Nancy Gavert;Klaus-Peter Janssen

  • Mucinous and Signet-Ring Cell Colorectal Cancers Differ from Classical Adenocarcinomas in Tumor Biology and Prognosis

    Ulrich Nitsche;Anina Zimmermann;Christoph Späth;Tara Müller

  • Gut microbiota modulate T cell trafficking into human colorectal cancer

    Eleonora Cremonesi;Valeria Governa;Jesus Francisco Glaus Garzon;Valentina Mele

  • Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells.

    Frank Schmitz;Antje Heit;Stefan Dreher;Katharina Eisenächer

  • Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

    Hua-Sheng Chiu;Sonal Somvanshi;Ektaben Patel;Ting-Wen Chen

  • High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue

    Alice Ly;Achim Buck;Benjamin Balluff;Na Sun

  • Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice

    Bastian Seubert;Barbara Grünwald;Julia Kobuch;Haissi Cui

  • Microarray-Based Prediction of Tumor Response to Neoadjuvant Radiochemotherapy of Patients With Locally Advanced Rectal Cancer

    Caroline Rimkus;Jan Friederichs;Anne–laure Boulesteix;Jörg Theisen

Frequent Co-Authors

Robert D. Rosenberg
Robert D. Rosenberg Technical University of Munich
Sylvie Robine
Sylvie Robine Institute Curie
Bernhard Holzmann
Bernhard Holzmann Technical University of Munich
Daniel Louvard
Daniel Louvard Institute Curie
Ludger Johannes
Ludger Johannes Institute Curie
Andrew D. Cherniack
Andrew D. Cherniack Broad Institute
Michael Schleicher
Michael Schleicher Ludwig-Maximilians-Universität München
Houtan Noushmehr
Houtan Noushmehr Henry Ford Health System
Christina Yau
Christina Yau University of California, San Francisco
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences

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