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Tomohiko Ohwada

Tomohiko Ohwada

D-Index & Metrics

Chemistry

D-Index
46
Citations
7291
World Ranking
16088
National Ranking
1268

Overview

Tomohiko Ohwada is affiliated with the University of Tokyo in Japan. Their research has a significant focus on materials science, biochemistry, genetics and molecular biology, and chemistry. The primary fields of study include materials chemistry, molecular biology, and organic chemistry, with additional work in spectroscopy and physiology.

The scientist's research topics cover a range of specialized areas: crystallization and solubility studies, X-ray diffraction in crystallography, chemical synthesis and analysis, lipid membrane structure and behavior, receptor mechanisms and signaling, sphingolipid metabolism and signaling, and synthesis and catalytic reactions.

Recent papers authored or co-authored by Tomohiko Ohwada include:

  • Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors, 2022, published in Molecules
  • Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis, 2021, published in Green Synthesis and Catalysis
  • Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST-THF) System, 2023, published in Organic Letters
  • Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors, 2020, published in Journal of Medicinal Chemistry
  • Friedel-Crafts-Type Acylation and Amidation Reactions in Strong Brønsted Acid: Taming Superelectrophiles, 2022, published in Molecules

Frequent co-authors in their research collaborations include:

  • Yuko Otani
  • Tadashi Hyodo
  • Kentaro Yamaguchi
  • Tomohiro Fujino
  • Junken Aoki

Tomohiko Ohwada's publications often appear in several consistent venues, including:

  • The Cambridge Structural Database
  • The Journal of Organic Chemistry
  • Organic Letters
  • Journal of Medicinal Chemistry
  • Chemical and Pharmaceutical Bulletin

Best Publications

  • TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

    Asuka Inoue;Jun Ishiguro;Hajime Kitamura;Naoaki Arima

  • Generation of Functionalized Asymmetric Benzynes with TMP-Zincates. Effects of Ligands on Selectivity and Reactivity of Zincates

    Masanobu Uchiyama;Tomoko Miyoshi;Yumiko Kajihara;Takao Sakamoto

  • Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

    Masaki Tsuchiya;Yuji Hara;Yuji Hara;Masaki Okuda;Karin Itoh

  • Regio- and chemoselective direct generation of functionalized aromatic aluminum compounds using aluminum ate base.

    Masanobu Uchiyama;Hiroshi Naka;Yotaro Matsumoto;Tomohiko Ohwada

  • An evaluation of amide group planarity in 7-azabicyclo[2.2.1]heptane amides. Low amide bond rotation barrier in solution.

    Yuko Otani;Osamu Nagae;Yuji Naruse;Satoshi Inagaki

  • Prototype Pictet−Spengler Reactions Catalyzed by Superacids. Involvement of Dicationic Superelectrophiles

    Akihiro Yokoyama;Tomohiko Ohwada;Koichi Shudo

  • Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells.

    Aki Yamada;Norikazu Gaja;Susumu Ohya;Katsuhiko Muraki

  • Temperature-dependent fluorescence lifetime of a fluorescent polymeric thermometer, poly(N-isopropylacrylamide), labeled by polarity and hydrogen bonding sensitive 4-sulfamoyl-7-aminobenzofurazan.

    Chie Gota;Seiichi Uchiyama;Toshitada Yoshihara;Seiji Tobita

  • INVOLVEMENT OF DICATIONIC SPECIES AS THE REACTIVE INTERMEDIATES IN GATTERMANN, HOUBEN-HOESCH, AND FRIEDEL-CRAFTS REACTIONS OF NONACTIVATED BENZENES

    Yasuo Sato;Michihisa Yato;Tomohiko Ohwada;Shinichi Saito

  • Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA 6

    Reiya Taniguchi;Asuka Inoue;Misa Sayama;Akiharu Uwamizu

  • Structural Features of Aliphatic N-Nitrosamines of 7-Azabicyclo[2.2.1]heptanes That Facilitate N−NO Bond Cleavage

    Tomohiko Ohwada;Motoko Miura;Haruko Tanaka;Shigeru Sakamoto

  • Molecular Basis of Pimarane Compounds as Novel Activators of Large-Conductance Ca2+-Activated K+ Channel α-Subunit

    Yuji Imaizumi;Kazuho Sakamoto;Aki Yamada;Aya Hotta

  • Molecular mechanism of pharmacological activation of BK channels

    Guido Gessner;Yong-Mei Cui;Yuko Otani;Tomohiko Ohwada

  • Superacid-Catalyzed Electrocyclization of 1-Phenyl-2-propen-1-ones to 1-Indanones. Kinetic and Theoretical Studies of Electrocyclization of Oxonium−Carbenium Dications

    Takayoshi Suzuki;Tomohiko Ohwada;Koichi Shudo

  • Friedel-Crafts-type reactions involving di- and tricationic species. Onium-allyl dications and O,O-diprotonated aci-nitro species bearing a protonated carbonyl group

    Tomohiko Ohwada;Naoko Yamagata;Koichi Shudo

  • Rationale for the acidity of Meldrum's acid. Consistent relation of C-H acidities to the properties of localized reactive orbital.

    Satoshi Nakamura;Hajime Hirao;Tomohiko Ohwada

  • Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (Muta™Mouse)

    Arihiro Kohara;Takayoshi Suzuki;Masamitsu Honma;Tomohiko Ohwada

  • GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.

    Hajime Kitamura;Kumiko Makide;Akira Shuto;Masaya Ikubo

  • Environment-sensitive fluorophore emitting in protic environments.

    Seiichi Uchiyama;Kazuyuki Takehira;Toshitada Yoshihara;Seiji Tobita

  • Development of a catalytic electron transfer system mediated by transition metal ate complexes: applicability and tunability of electron-releasing potential for organic transformations.

    Masanobu Uchiyama;Yotaro Matsumoto;Shinji Nakamura;Tomohiko Ohwada

  • Regio- and Chemoselective Direct Generation of Functionalized Aromatic Aluminum Compounds Using Aluminum Ate Base.

    Masanobu Uchiyama;Hiroshi Naka;Yotaro Matsumoto;Tomohiko Ohwada

Frequent Co-Authors

Koichi Shudo
Koichi Shudo University of Tokyo
Kentaro Yamaguchi
Kentaro Yamaguchi Tokushima Bunri University
Junken Aoki
Junken Aoki Tohoku University
Masanobu Uchiyama
Masanobu Uchiyama University of Tokyo
Asuka Inoue
Asuka Inoue Tohoku University
Yasuo Mori
Yasuo Mori Kyoto University
Takayoshi Suzuki
Takayoshi Suzuki Osaka University
Hajime Hirao
Hajime Hirao City University of Hong Kong
Makoto Fujita
Makoto Fujita University of Tokyo
Shiroh Futaki
Shiroh Futaki Kyoto University

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