World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
27116
World Ranking
5479
National Ranking
2601

Research.com Recognitions

  • 2008 - Member of the National Academy of Sciences
  • 2007 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Gail Mandel is affiliated with Oregon Health & Science University in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, with particular emphasis on RNA research and splicing, RNA regulation and disease, and RNA modifications and cancer.

The main topics covered in their work include:

  • RNA Research and Splicing
  • RNA Regulation and Disease
  • RNA Modifications and Cancer
  • Epigenetics and DNA Methylation
  • CRISPR and Genetic Engineering
  • Single-cell and Spatial Transcriptomics
  • RNA and Protein Synthesis Mechanisms

Among their frequent collaborators are Jenna R. Fisk, Shannon K. McWeeney, John R. Sinnamon, Sophia Jeng, and John F. Yung.

Gail Mandel has published in several notable scientific journals. Venues with multiple publications include bioRxiv (Cold Spring Harbor Laboratory), while other publications have appeared in Cell Reports, Nature Communications, Proceedings of the National Academy of Sciences, and Nature Biotechnology.

Recent significant papers authored by Mandel and collaborators include:

  • Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA, 2024, Nature Biotechnology
  • High-throughput robust single-cell DNA methylation profiling with sciMETv2, 2022, Nature Communications
  • Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome, 2022, Proceedings of the National Academy of Sciences
  • The Genome-Wide Binding Profile for Human RE1 Silencing Transcription Factor Unveils a Unique Genetic Circuitry in Hippocampus, 2021, Journal of Neuroscience
  • In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing, 2020, Cell Reports

Gail Mandel's work is situated in subfields including molecular biology and cancer research. Their research integrates advanced techniques spanning epigenetics, RNA editing, and single-cell profiling.

They have been recognized within the scientific community through election to several prestigious bodies, including becoming a Member of the National Academy of Sciences in 2008, a Fellow of the American Academy of Arts and Sciences in 2007, and a Fellow of the American Association for the Advancement of Science (AAAS) in 2003.

Best Publications

  • Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

    Marc R. Montminy;Kevin A. Sevarino;John A. Wagner;Gail Mandel

  • Nomenclature of voltage-gated sodium channels.

    Alan L. Goldin;Robert L. Barchi;John H. Caldwell;Franz Hofmann

  • REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

    Jayhong A Chong;José Tapia-Ramirez;Sandra Kim;Juan J Toledo-Aral

  • REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

    Nurit Ballas;Christopher Grunseich;Diane D. Lu;Joan C. Speh

  • Defining the CREB Regulon: A Genome-Wide Analysis of Transcription Factor Regulatory Regions

    Soren Impey;Sean R. McCorkle;Hyunjoo Cha-Molstad;Jami M. Dwyer

  • Reciprocal actions of REST and a microRNA promote neuronal identity.

    Cecilia Conaco;Stefanie Otto;Jong Jin Han;Gail Mandel

  • Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

    Kristen Jepsen;Ola Hermanson;Thandi M Onami;Anatoli S Gleiberman

  • Primary structure and functional expression of a mammalian skeletal muscle sodium channel

    James S. Trimmer;Sharon S. Cooperman;Sally A. Tomiko;Jiuying Zhou

  • Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

    Juan J. Toledo-Aral;Brenda L. Moss;Brenda L. Moss;Zhi Jun He;Adam G. Koszowski

  • CoREST: A functional corepressor required for regulation of neural-specific gene expression

    María E. Andrés;Corinna Burger;María J. Peral-Rubio;Elena Battaglioli

  • Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

    Victoria V. Lunyak;Robert Burgess;Robert Burgess;Gratien G. Prefontaine;Charles Nelson

  • A Genetic Screen for Candidate Tumor Suppressors Identifies REST

    Thomas F. Westbrook;Eric S. Martin;Michael R. Schlabach;Yumei Leng

  • Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

    Nurit Ballas;Daniel T Lioy;Christopher Grunseich;Gail Mandel;Gail Mandel

  • The many faces of REST oversee epigenetic programming of neuronal genes.

    Nurit Ballas;Gail Mandel

  • Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.

    Matthew E Klein;Daniel T Lioy;Lin Ma;Soren Impey

  • Regulation of neuronal traits by a novel transcriptional complex.

    Nurit Ballas;Elena Battaglioli;Fouad Atouf;Maria E. Andres

  • microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

    Stephen T. Magill;Xiaolu A. Cambronne;Bryan W. Luikart;Daniel T. Lioy

  • Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

    Tatiana Boiko;Matthew N. Rasband;S.Rock Levinson;John H. Caldwell

  • Thyrotropin-releasing hormone precursor: characterization in rat brain

    Ronald M. Lechan;Ping Wu;Ivor M. D. Jackson;Hugh Wolf

  • A biochemical approach to identifying microRNA targets

    Fedor V. Karginov;Cecilia Conaco;Zhenyu Xuan;Bryan H. Schmidt

Frequent Co-Authors

Richard H. Goodman
Richard H. Goodman Oregon Health & Science University
Shannon K. McWeeney
Shannon K. McWeeney Oregon Health & Science University
Shin-ichi Higashijima
Shin-ichi Higashijima National Institutes of Natural Sciences
Joseph R. Fetcho
Joseph R. Fetcho Cornell University
Stuart H. Orkin
Stuart H. Orkin Harvard University
Michael G. Rosenfeld
Michael G. Rosenfeld University of California, San Diego
Soren Impey
Soren Impey Oregon Health & Science University
John J. Dunn
John J. Dunn Brookhaven National Laboratory
James S. Trimmer
James S. Trimmer University of California, Davis
Cole Trapnell
Cole Trapnell University of Washington

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