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Immunology

D-Index
61
Citations
12287
World Ranking
3254
National Ranking
1518

Overview

Mark Boothby is affiliated with Vanderbilt University Medical Center in the United States. Their research spans several fields with a focus on immunology, microbiology, biochemistry, genetics, molecular biology, and medicine.

Their published works primarily address immune cell function and interaction, cancer, hypoxia, and metabolism, diabetes and associated disorders, T-cell and B-cell immunology, pancreatic function and diabetes, PARP inhibition in cancer therapy, and immunodeficiency and autoimmune disorders.

Frequent coauthors in Boothby's research include Sung Hoon Cho, Ariel Raybuck, Shawna K. Brookens, Deanna N. Edwards, and Shan Wang.

Boothby's most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • The Journal of Immunology
  • Journal of Clinical Investigation
  • JCI Insight

Recent notable papers include:

  • "Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer" (2020), Journal of Clinical Investigation
  • "Supplying the trip to antibody production-nutrients, signaling, and the programming of cellular metabolism in the mature B lineage" (2021), Cellular and Molecular Immunology
  • "Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry" (2020), Analytical Chemistry
  • "AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory" (2020), The Journal of Immunology
  • "Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity" (2020), JCI Insight

Boothby's research contributions mostly focus on subfields such as immunology, molecular biology, cancer research, oncology, and genetics. The work tends to involve detailed investigations of cellular metabolism, immune responses, and mechanisms involved in cancer therapy and immunological memory.

Best Publications

  • Metabolic coordination of T cell quiescence and activation.

    Nicole M. Chapman;Mark R. Boothby;Hongbo Chi

  • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

    William C. Powell;Barbara Fingleton;Carole L. Wilson;Mark Boothby

  • Interleukin-4 and Interleukin-13 Signaling Connections Maps

    Ann E. Kelly-Welch;Erica M. Hanson;Mark R. Boothby;Achsah D. Keegan

  • Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

    Keunwook Lee;Prathyusha Gudapati;Srdjan Dragovic;Charles Spencer

  • A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

    Hsiou-Chi Liou;Mark R. Boothby;Patricia W. Finn;Ruth Davidon

  • Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.

    Deanna N. Edwards;Verra M. Ngwa;Ariel L. Raybuck;Shan Wang

  • Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor

    Li Yang;Noboru Yamagata;Rajwardhan Yadav;Suzanne Brandon

  • Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

    Mark R. Boothby;Ana L. Mora;David C. Scherer;Jeffrey A. Brockman

  • PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

    Hiroshi Iwata;Claudia Goettsch;Amitabh Sharma;Piero Ricchiuto

  • Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

    Sung Hoon Cho;Ariel L. Raybuck;Kristy Stengel;Mei Wei

  • Cutting Edge: Influence of Tmevpg1, a Long Intergenic Noncoding RNA, on the Expression of Ifng by Th1 Cells

    Sarah P. Collier;Patrick L. Collins;Christopher L. Williams;Mark R. Boothby

  • A single gonadotropin alpha-subunit gene in normal tissue and tumor-derived cell lines.

    M Boothby;R W Ruddon;C Anderson;D McWilliams

  • Metabolic Regulation of the Immune Humoral Response

    Mark Boothby;Robert C. Rickert

  • Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.

    Mark A. Aronica;Ana L. Mora;Daphne B. Mitchell;Patricia W. Finn

  • Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta.

    M Hoshina;M Boothby;I Boime

  • The beta subunit of human chorionic gonadotropin is encoded by multiple genes.

    P Policastro;C E Ovitt;M Hoshina;H Fukuoka

  • IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells

    Laura E. Gordy;Jelena S. Bezbradica;Andrew I. Flyak;Charles T. Spencer

  • PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

    Jiqing Sai;Jiqing Sai;Philip Owens;Philip Owens;Sergey V. Novitskiy;Oriana E. Hawkins;Oriana E. Hawkins

  • Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor

    Shreevrat Goenka;Mark Boothby

  • Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

    P Rothman;S C Li;B Gorham;L Glimcher

  • TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

    Mauricio T. Caballero;M. Elina Serra;Patricio L. Acosta;Jacqui Marzec

  • T helper type 1–specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-γ promoter are Stat4 dependent

    Fuping Zhang;Mark Boothby

  • Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity.

    Sung Hoon Cho;Sung Hoon Cho;Ariel L Raybuck;Julianna Blagih;Edna Kemboi

  • NF-κB Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes

    Aleksandar K. Stanic;Jelena S. Bezbradica;Jang-June Park;Naoto Matsuki

  • PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.

    Sung Hoon Cho;Shreevrat Goenka;Tiina Henttinen;Prathyusha Gudapati

Frequent Co-Authors

Jin Chen
Jin Chen Vanderbilt University
Laurie H. Glimcher
Laurie H. Glimcher Harvard University
Irving Boime
Irving Boime Washington University in St. Louis
Sebastian Joyce
Sebastian Joyce Vanderbilt University Medical Center
Patricia W. Finn
Patricia W. Finn University of Illinois at Chicago
Hsiou-Chi Liou
Hsiou-Chi Liou Cornell University
Thomas M. Aune
Thomas M. Aune Vanderbilt University Medical Center
Robert P. Schleimer
Robert P. Schleimer Northwestern University
Steve N. Georas
Steve N. Georas University of Rochester Medical Center
Ann Richmond
Ann Richmond Vanderbilt University

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