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Immunology

D-Index
67
Citations
24873
World Ranking
2639
National Ranking
1259

Overview

Maria-Luisa Alegre is affiliated with the University of Chicago in the United States. Their research contributions span immunology, microbiology, and medicine, with a significant focus on transplantation and immune cell function. Their work intersects several specialized subfields such as immunology, molecular biology, transplantation, surgery, and physiology.

Alegre's recent publications reflect ongoing investigations into immune mechanisms related to transplantation tolerance, immune responses, and the microbiota's role in health. Notable papers include:

  • Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice, 2021, Journal of Clinical Investigation
  • Tregs in transplantation tolerance: role and therapeutic potential, 2023, Frontiers in Transplantation
  • Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival, 2023, American Journal of Transplantation
  • Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination, 2020, Science Advances
  • Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells, 2020, Journal of Clinical Investigation

The scientist frequently collaborates with others active in transplantation and immunology research. Their most common coauthors include Anita S. Chong, Christine McIntosh, A Cassano, Martin Sepulveda, and Luqiu Chen.

Publication venues for Alegre emphasize transplant immunology and clinical immunology fields. Prominent journals publishing their work include:

  • American Journal of Transplantation
  • The Journal of Immunology
  • Journal of Clinical Investigation
  • JCI Insight
  • Transplantation

The focus of their studies can be seen in the main topics covered by their research outputs. These include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Renal Transplantation Outcomes and Treatments
  • Gut microbiota and health
  • Immunotherapy and Immune Responses
  • Reproductive System and Pregnancy
  • Immune Response and Inflammation

Overall, Alegre's research contributes to understanding immune tolerance mechanisms, particularly in transplantation contexts, with an interest in how immune cell functions and microbial factors influence allograft survival and immune response modulation.

Best Publications

  • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

    Ayelet Sivan;Leticia Corrales;Nathaniel Hubert;Jason B. Williams

  • The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

    Vyara Matson;Jessica Fessler;Riyue Bao;Tara Chongsuwat

  • STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

    Seng Ryong Woo;Mercedes Beatriz Fuertes;Leticia Corrales;Stefani Spranger

  • Modulation of tryptophan catabolism by regulatory T cells.

    Francesca Fallarino;Ursula Grohmann;Kwang Woo Hwang;Ciriana Orabona

  • Serum Cytokine Levels in Human Septic Shock: Relation to Multiple-System Organ Failure and Mortality

    Michaël Pinsky;Jean Louis Vincent;Jacques Devière;Maria-Luisa Alegre

  • T-cell regulation by CD28 and CTLA-4

    Maria-Luisa Alegre;Kenneth A. Frauwirth;Craig B. Thompson

  • CTLA-4 Gene Polymorphism at Position 49 in Exon 1 Reduces the Inhibitory Function of CTLA-4 and Contributes to the Pathogenesis of Graves’ Disease

    Tsuyoshi Kouki;Yoshikuni Sawai;Cyprian A. Gardine;Maria-Elena Fisfalen

  • Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

    Tomas Vilimas;Joaquina Mascarenhas;Teresa Palomero;Malay Mandal

  • REGULATION OF SURFACE AND INTRACELLULAR EXPRESSION OF CTLA4 ON MOUSE T CELLS

    M L Alegre;P J Noel;B J Eisfelder;E Chuang

  • GATA-3: an unexpected regulator of cell lineage determination in skin

    Charles K. Kaufman;Ping Zhou;H. Amalia Pasolli;Michael Rendl

  • In vitro characterization of five humanized OKT3 effector function variant antibodies.

    Danlin Xu;Maria Luisa Alegre;Sally S. Varga;Annette L. Rothermel

  • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.

    E Chuang;M L Alegre;C S Duckett;P J Noel

  • TLR engagement prevents transplantation tolerance

    L. Chen;T. Wang;P. Zhou;L. Ma

  • A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.

    M.-L. Alegre;L. J. Peterson;Danlin Xu;H. A. Sattar

  • Tumor-associated fibroblasts predominantly come from local and not circulating precursors.

    Ainhoa Arina;Christian Idel;Elizabeth M. Hyjek;Maria-Luisa Alegre

  • Thymic regulatory T cells arise via two distinct developmental programs

    David L. Owen;Shawn A. Mahmud;Louisa E. Sjaastad;Jason B. Williams

  • Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

    Hua Lin;Jeffrey C. Rathmell;Gary S. Gray;Craig B. Thompson

  • Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

    Sumit K. Subudhi;Ping Zhou;Lisa M. Yerian;Robert K. Chin

  • Expression and Function of CTLA-4 in Th1 and Th2 Cells

    Maria-Luisa Alegre;Helena Shiels;Craig B. Thompson;Thomas F. Gajewski

  • Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock

    Arnaud Marchant;Maria-Luisa Alegre;Alain Hakim;Géraldine Pierard

  • Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.

    M L Alegre;A M Collins;V L Pulito;R A Brosius

Frequent Co-Authors

Anita S. Chong
Anita S. Chong University of Chicago
Thomas F. Gajewski
Thomas F. Gajewski University of Chicago
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Michel Goldman
Michel Goldman Université Libre de Bruxelles
Yang-Xin Fu
Yang-Xin Fu Tsinghua University
Oberdan Leo
Oberdan Leo Université Libre de Bruxelles
Chyung Ru Wang
Chyung Ru Wang Northwestern University
Sandrine Florquin
Sandrine Florquin University of Amsterdam
Peter Vandenabeele
Peter Vandenabeele Ghent University

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Related Online Degrees & Career Pathways

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