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Immunology

D-Index
68
Citations
18443
World Ranking
2572
National Ranking
33

Overview

Oberdan Leo is affiliated with the Université Libre de Bruxelles in Belgium and has contributed extensively to the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Their primary research focus spans Immunology, Oncology, Molecular Biology, Cancer Research, and Physiology.

Their work covers several key topics, including:

  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • T-cell and B-cell Immunology
  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • IL-33, ST2, and ILC Pathways
  • Cancer, Hypoxia, and Metabolism

Recent publications by Oberdan Leo include:

  • "Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species," 2020, Scientific Reports
  • "Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells," 2020, Frontiers in Immunology
  • "Inhaled dry powder cisplatin increases antitumour response to anti-PD1 in a murine lung cancer model," 2022, Journal of Controlled Release
  • "PHD2 Constrains Antitumor CD8+ T-cell Activity," 2023, Cancer Immunology Research
  • "Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production," 2022, European Journal of Immunology

Oberdan Leo frequently collaborates with several researchers, including:

  • Muriel Moser
  • Stanislas Goriely
  • Abdulkader Azouz
  • Sébastien Denanglaire
  • Valérie Acolty

The scientist publishes regularly in a number of journals such as Cancer Immunology Research, Frontiers in Immunology, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and Journal of Controlled Release. Among these, Frontiers in Immunology and Cancer Immunology Research are recurrent venues.

Oberdan Leo's research encompasses a wide range of immunological topics with an emphasis on T cell behavior, regulatory pathways affecting immune response, and cancer immunotherapy. The work contributes to improving understanding of the cellular and molecular mechanisms behind immune cell regulation and cancer progression.

Best Publications

  • Identification of a monoclonal antibody specific for a murine T3 polypeptide

    Oberdan Leo;Michele Foo;David H. Sachs;Lawrence E. Samelson

  • CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.

    Roberto Maldonado-López;Thibaut De Smedt;Patrick Michel;Jacques Godfroid

  • Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

    T. De Smedt;B. Pajak;E. Muraille;L. Lespagnard

  • Effect of interleukin-10 on dendritic cell maturation and function

    Thibaut de Smedt;Marcelle van Mechelen;Geneviève De Becker;Jacques Urbain

  • Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.

    Anthony Rongvaux;Robin J. Shea;Martha H. Mulks;Daniel Gigot

  • DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1

    Manjusha Dixit;Eugénie Ansseau;Alexandra Tassin;Sara Winokur

  • Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo.

    VéRonique Flamand;Thierry Sornasse;Kris Thielemans;Christian Demanet

  • The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.

    Valeria Kowaljow;Aline Marcowycz;Eugénie Ansseau;Cecilia B. Conde

  • TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?

    Eric Muraille;Oberdan Leo;Muriel Moser

  • Reconstructing eukaryotic NAD metabolism.

    Anthony Rongvaux;Fabienne Andris;Frédéric Van Gool;Oberdan Leo

  • Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

    Frédéric Van Gool;Mara Gallí;Cyril Gueydan;Véronique Kruys

  • Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

    Nathalie Busso;Mahir Karababa;Massimo Nobile;Aline Rolaz

  • Glucocorticoids down-regulate dendritic cell function in vitro and in vivo.

    Muriel Moser;Thibaut De Smedt;Thierry Sornasse;Françoise Tielemans

  • Key concepts in immunology.

    Muriel Moser;Oberdan Leo

  • CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo.

    Guillaume Oldenhove;Magali de Heusch;Georgette Urbain-Vansanten;Jacques Urbain

  • Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

    T Sornasse;V Flamand;G De Becker;H Bazin

  • Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response.

    Eric Muraille;Carl De Trez;Maryse Brait;Patrick De Baetselier

  • Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

    Tanya Dimova;Margreet Brouwer;Françoise Gosselin;Joël Tassignon

  • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

    Fouad Eddahri;Sébastien Denanglaire;Fabrice Bureau;Rosanne Spolski

  • Revisiting the Th1/Th2 Paradigm

    Eric Muraille;Oberdan Leo

Frequent Co-Authors

Jacques Urbain
Jacques Urbain Université Libre de Bruxelles
Muriel Moser
Muriel Moser Université Libre de Bruxelles
Kris Thielemans
Kris Thielemans Vrije Universiteit Brussel
Michel Goldman
Michel Goldman Université Libre de Bruxelles
Hervé Bazin
Hervé Bazin Université Catholique de Louvain
Maria-Luisa Alegre
Maria-Luisa Alegre University of Chicago
Fabrice Bureau
Fabrice Bureau University of Liège
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Peter Vandenabeele
Peter Vandenabeele Ghent University
Stanislas Goriely
Stanislas Goriely Université Libre de Bruxelles

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