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Immunology

D-Index
49
Citations
11265
World Ranking
4316
National Ranking
1962

Overview

Achsah D. Keegan is affiliated with the University of Maryland, Baltimore in the United States. Their research primarily focuses on the field of Medicine, with a particular emphasis on Immunology, Molecular Biology, Physiology, Cellular and Molecular Neuroscience, and Pulmonary and Respiratory Medicine.

The scientist's work explores several key topics, including:

  • Asthma and respiratory diseases
  • Axon Guidance and Neuronal Signaling
  • Immune Cell Function and Interaction
  • Pediatric health and respiratory diseases
  • IL-33, ST2, and ILC Pathways
  • Immune cells in cancer
  • Eicosanoids and Hypertension Pharmacology

Recent publications by Achsah D. Keegan include:

  • "Recent advances in understanding the role of IL-4 signaling," 2021, Faculty Reviews
  • "Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation," 2022, Frontiers in Immunology
  • "Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection," 2021, Molecular Medicine
  • "The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions," 2021, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • "M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice," 2023, mBio

These papers address various aspects of immunology, inflammation, and respiratory diseases, reflecting the scientist's diverse yet interconnected research interests.

Achsah D. Keegan frequently collaborates with a number of researchers in related fields. Notable coauthors include:

  • Svetlana P. Chapoval
  • Kari Ann Shirey
  • Stefanie N. Vogel
  • Andrew F. Neuwald
  • Xiulan Qi

The scientist's work has been published most often in the following venues:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • The Journal of Immunology
  • Frontiers in Immunology
  • Faculty Reviews
  • Molecular Medicine

Best Publications

  • The IL-4 receptor: signaling mechanisms and biologic functions.

    Keats Nelms;Achsah D. Keegan;José Zamorano;John J. Ryan

  • Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

    Sherry L. LaPorte;Z. Sean Juo;Jana Vaclavikova;Leremy A. Colf

  • Interleukin-4 and Interleukin-13 Signaling Connections Maps

    Ann E. Kelly-Welch;Erica M. Hanson;Mark R. Boothby;Achsah D. Keegan

  • Regulation of inflammation by interleukin-4: a review of "alternatives".

    Irina G. Luzina;Irina G. Luzina;Achsah D. Keegan;Nicola M. Heller;Graham A. W. Rook

  • Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.

    F W Quelle;K Shimoda;W Thierfelder;C Fischer

  • Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.

    Unknown

  • An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

    Achsah D. Keegan;Keats Nelms;Morris White;Ling-Mei Wang

  • Multichain immune recognition receptors: similarities in structure and signaling pathways.

    Achsah D Keegan;William E Paul

  • Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R|[alpha]|-, TLR4-, and IFN-|[beta]|-dependent

    Kari Ann Shirey;Lioubov M. Pletneva;Adam C. Puche;Achsah D. Keegan

  • Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

    L M Wang;A D Keegan;W Li;G E Lienhard

  • Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

    John J. Ryan;Lisa J. McReynolds;Achsah Keegan;Lu Hai Wang

  • IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

    Ling-Mei Wang;A. D. Keegan;W. E. Paul;M. A. Heidaran

  • Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6.

    Svetlana Chapoval;Preeta Dasgupta;Nicolas J. Dorsey;Achsah D. Keegan

  • IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.

    J Zamorano;H Y Wang;L M Wang;J H Pierce

  • IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin

    Jose L. Moreno;Irina Mikhailenko;Mehrdad M. Tondravi;Achsah D. Keegan;Achsah D. Keegan

  • Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

    Nicola M. Heller;Xiulan Qi;Ilkka S. Junttila;Kari Ann Shirey

  • Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism

    Kari Ann Shirey;Leah E. Cole;Achsah D. Keegan;Stefanie N. Vogel

  • IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL

    Jose L. Moreno;Michele Kaczmarek;Achsah D. Keegan;Mehrdad Tondravi

  • Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention

    William M. Gwinn;Jesse M. Damsker;Rustom Falahati;Ifeanyi Okwumabua

  • Interleukin 4 receptor: signaling mechanisms

    Achsah D. Keegan;Keats Nelms;Ling-Mei Wang;Jacalyn H. Pierce

  • Suppression of the Inflammatory Immune Response Prevents the Development of Chronic Biofilm Infection Due to Methicillin-Resistant Staphylococcus aureus

    Ranjani Prabhakara;Janette M. Harro;Jeff G. Leid;Achsah D. Keegan

  • Similarities and differences in signal transduction by interleukin 4 and interleukin 13: Analysis of Janus kinase activation

    A D Keegan;J A Johnston;P J Tortolani;L J McReynolds

  • Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines.

    D H Conrad;T J Waldschmidt;W T Lee;M Rao

  • Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation

    X. R. Zhang;L. Y. Zhang;S. Devadas;L. Li

  • Interleukin 4 signals through two related pathways.

    Alessandra Pernis;Bruce Witthuhn;Achsah D. Keegan;Keats Nelms

Frequent Co-Authors

William E. Paul
William E. Paul National Institute of Allergy and Infectious Diseases
Jacalyn H. Pierce
Jacalyn H. Pierce National Institutes of Health
Daniel H. Conrad
Daniel H. Conrad Virginia Commonwealth University
Stefanie N. Vogel
Stefanie N. Vogel University of Maryland, Baltimore
Yufang Shi
Yufang Shi Soochow University
Jeffrey D. Hasday
Jeffrey D. Hasday University of Maryland, Baltimore
John J. Ryan
John J. Ryan Virginia Commonwealth University
Mark Boothby
Mark Boothby Vanderbilt University Medical Center
Donna L. Farber
Donna L. Farber Columbia University
Hiroshi Matsuda
Hiroshi Matsuda Tokyo University of Agriculture and Technology

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