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Warren W. Wakarchuk

Warren W. Wakarchuk

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
12936
World Ranking
7185
National Ranking
254

Overview

Warren W. Wakarchuk is affiliated with the University of Alberta in Canada and has a research focus primarily within the field of Biochemistry, Genetics and Molecular Biology. Their work extensively covers Molecular Biology, Organic Chemistry, Radiology, Nuclear Medicine and Imaging, Biotechnology, and Biomedical Engineering.

The scientist's main research topics include:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Monoclonal and Polyclonal Antibodies Research
  • Enzyme Production and Characterization
  • Galectins and Cancer Biology
  • Genomics and Phylogenetic Studies
  • Biofuel production and bioconversion

Wakarchuk has published numerous research papers, with recent notable works including:

  • "O-glycosylation and its role in therapeutic proteins," 2022, Bioscience Reports
  • "Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis," 2021, Proceedings of the National Academy of Sciences
  • "Four cellulose-active lytic polysaccharide monooxygenases from Cellulomonas species," 2021, Biotechnology for Biofuels
  • "7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins," 2021, ACS Central Science
  • "A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond," 2022, Journal of Biological Chemistry

The scientist has frequently published in the venues of:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Glycobiology
  • Journal of Biological Chemistry
  • UNC Libraries
  • Bioscience Reports

Collaborations have been a consistent element of Wakarchuk's research efforts. Frequent co-authors include Nicole Thompson, Stephen G. Withers, Hirak Saxena, A.B. Boraston, and B. Pluvinage, with Nicole Thompson being the most frequent collaborator.

Best Publications

  • Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.

    Karina Persson;Hoa D. Ly;Manuela Dieckelmann;Warren W. Wakarchuk

  • The genetic bases for the variation in the lipo-oligosaccharide of the mucosal pathogen, Campylobacter jejuni. Biosynthesis of sialylated ganglioside mimics in the core oligosaccharide

    Michel Gilbert;Marie-France Karwaski;Stéphane Bernatchez;N. Martin Young

  • Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis.

    Michel Gilbert;Jean-Robert Brisson;Marie-France Karwaski;Joseph Michniewicz

  • Mutational and crystallographic analyses of the active site residues of the Bacillus circulans xylanase.

    Warren W. Wakarchuk;Robert L. Campbell;Wing L. Sung;Jamshid Davoodi

  • The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of bacillus circulans xylanase.

    Lawrence P. McIntosh;Greg Hand;Philip E. Johnson;Manish D. Joshi

  • Stereoselective hydrolysis catalyzed by related beta-1,4-glucanases and beta-1,4-xylanases.

    J Gebler;N R Gilkes;M Claeyssens;D B Wilson

  • Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.

    Cecilia P C Chiu;Andrew G Watts;Luke L Lairson;Michel Gilbert

  • Phase variation of a β‐1,3 galactosyltransferase involved in generation of the ganglioside GM1‐like lipo‐oligosaccharide of Campylobacter jejuni

    Dennis Linton;Michel Gilbert;Paul G. Hitchen;Anne Dell

  • High-throughput screening methodology for the directed evolution of glycosyltransferases

    Amir Aharoni;Karena Thieme;Cecilia P C Chiu;Sabrina Buchini

  • Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses.

    Andrey V. Karlyshev;Olivia G. Champion;Carol Churcher;Jean-Robert Brisson

  • Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.

    Ian C. Schoenhofen;David J. McNally;Evgeny Vinogradov;Dennis Whitfield

  • Cloning of the Lipooligosaccharide α-2,3-Sialyltransferase from the Bacterial Pathogens Neisseria meningitidis and Neisseria gonorrhoeae

    Michel Gilbert;David C. Watson;Anna-Maria Cunningham;Michael P. Jennings

  • The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168

    Frank St. Michael;Christine M. Szymanski;Jianjun Li;Kenneth H. Chan

  • Thermostabilization of the Bacillus circulansxylanase by the introduction of disulfide bonds

    Warren W. Wakarchuk;Wing L. Sung;Robert L. Campbell;Anna Cunningham

  • A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria.

    Bernard Priem;Michel Gilbert;Warren W. Wakarchuk;Alain Heyraud

  • Thermostabilization of the Bacillus circulans xylanase by the introduction of disulfide bonds.

    W.W Wakarchuk;W.L Sung;R.L Campbell;A Cunningham

  • Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

    Wade Abbott;Orly Alber;Ed Bayer;Jean-Guy Berrin

  • The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion.

    M. Gilbert;R. Bayer;A.-M. Cunningham;S. Defrees

  • Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunit.

    Marc A. B. Kolkman;Warren Wakarchuk;Piet J. M. Nuijten;Bernard A. M. Van Der Zeijst

  • A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni.

    Stéphane Bernatchez;Christine M. Szymanski;Noboru Ishiyama;Jianjun Li

Frequent Co-Authors

Michel Gilbert
Michel Gilbert National Academies of Sciences, Engineering, and Medicine
Stephen G. Withers
Stephen G. Withers University of British Columbia
N. Martin Young
N. Martin Young National Research Council Canada
Natalie C. J. Strynadka
Natalie C. J. Strynadka University of British Columbia
Jianjun Li
Jianjun Li Chinese Academy of Sciences
Jean-Robert Brisson
Jean-Robert Brisson National Research Council Canada
James C. Richards
James C. Richards National Academies of Sciences, Engineering, and Medicine
Douglas G. Kilburn
Douglas G. Kilburn University of British Columbia
Robert C. Miller
Robert C. Miller University of British Columbia
Susan M. Logan
Susan M. Logan National Research Council Canada

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