Alan Eastman

Overview

Best Publications

• Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia.

  Michael A. Barry;Catherine A. Behnke;Alan Eastman

  1234
  Citations

• UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

  Qizhi Wang;Saijun Fan;Alan Eastman;Peter J. Worland

  695
  Citations

• Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA.

  Alan Eastman

  627
  Citations

• Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

  Christine M. Sorenson;Michael A. Barry;Alan Eastman

  626
  Citations

• Identification of deoxyribonuclease II as an endonuclease involved in apoptosis

  Michael A. Barry;Alan Eastman

  564
  Citations

• Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II).

  Alan Eastman

  449
  Citations

• Mechanism of cis-Diamminedichloroplatinum(II)-induced Cytotoxicity: Role of G2 Arrest and DNA Double-Strand Breaks

  Christine M. Sorenson;Alan Eastman

  435
  Citations

• Etoposide-induced Apoptosis in Human HL-60 Cells Is Associated with Intracellular Acidification

  Michael A. Barry;Jason E. Reynolds;Alan Eastman

  387
  Citations

• The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis?

  Alan Eastman;Michael A. Barry

  386
  Citations

• Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification ROLE OF THE Na/H-ANTIPORT

  Jinfang Li;Alan Eastman

  353
  Citations

• Mcl-1, a Member of the Bcl-2 Family, Delays Apoptosis Induced by c-Myc Overexpression in Chinese Hamster Ovary Cells

  J. E. Reynolds;Tao Yang;Liping Qian;J. D. Jenkinson

  350
  Citations

• Multiple Mechanisms of Resistance to cis-Diamminedichloroplatinum(II) in Murine Leukemia L1210 Cells

  Victoria M. Richon;Nancy Schulte;Alan Eastman

  328
  Citations

• Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

  Roderick T. Bunch;Alan Eastman

  327
  Citations

• Microtubule destabilising agents: far more than just antimitotic anticancer drugs.

  Darcy Bates;Alan Eastman

  305
  Citations

• Influence of cis-Diamminedichloroplatinum(II) on DNA Synthesis and Cell Cycle Progression in Excision Repair Proficient and Deficient Chinese Hamster Ovary Cells

  Christine M. Sorenson;Alan Eastman

  301
  Citations

• Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH.

  Michael A. Barry;Alan Eastman

  253
  Citations

• Interaction of trans-diamminedichloroplatinum(II) with DNA: formation of monofunctional adducts and their reaction with glutathione

  Alan Eastman;Michael A. Barry

  239
  Citations

• Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors.

  J A McBain;A Eastman;C S Nobel;G C Mueller

  234
  Citations

• Cell cycle checkpoints and their impact on anticancer therapeutic strategies

  Alan Eastman

  213
  Citations

• The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells.

  C Demarcq;R T Bunch;D Creswell;A Eastman

  200
  Citations