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D-Index & Metrics

Molecular Biology

D-Index
53
Citations
7530
World Ranking
2401
National Ranking
90

Overview

Marc Leng was affiliated with the Centre national de la recherche scientifique (CNRS) in France. Throughout their career, they contributed to the field of Biochemistry, Genetics and Molecular Biology, focusing specifically on subfields such as Molecular Biology, Genetics, Ecology, Nutrition and Dietetics, and Materials Chemistry.

Their research topics included:

  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions
  • CRISPR and Genetic Engineering
  • Trace Elements in Health
  • Evolution and Genetic Dynamics
  • Enzyme Structure and Function

Marc Leng authored numerous scientific papers published in various venues. Notable papers included:

  • Regulatory interplay between small RNAs and transcription termination factor Rho, 2020, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame, 2022, mBio
  • A Large Insertion Domain in the Rho Factor From a Low G + C, Gram-negative Bacterium is Critical for RNA Binding and Transcription Termination Activity, 2021, Journal of Molecular Biology
  • Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism, 2022, Communications Biology
  • Rho-dependent transcriptional switches regulate the bacterial response to cold shock, 2024, Molecular Cell

The scientist collaborated frequently with several co-authors, including:

  • Mildred Delaleau
  • Isabelle Simon
  • Annie Schwartz
  • Éric Eveno
  • Emmanuel Saridakis

Marc Leng published work in a variety of scientific venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • mBio
  • Molecular Cell

In addition to articles, Marc Leng contributed to book publications. One such work was published by Springer Science+Business Media:

  • RNA Remodeling Proteins, 2020

Best Publications

  • A study of polyadenylic acid at neutral pH.

    Marc Leng;Gary Felsenfeld

  • DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

    Viktor Brabec;Marc Leng

  • Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity.

    Jewel T. Shapiro;Marc Leng;Gary Felsenfeld

  • Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.

    Paul Tchen;Robert P. P. Fuchs;Evelyne Sage;Marc Leng

  • Interstrand cross-links are preferentially formed at the d(GC) sites in the reaction between cis-diamminedichloroplatinum (II) and DNA.

    M A Lemaire;A Schwartz;A R Rahmouni;M Leng

  • Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 Å resolution: Hydration at the platinated site

    Franck Coste;Jean-Marc Malinge;Laurence Serre;William Shepard

  • The preferential interactions of polylysine and polyarginine with specific base sequences in DNA.

    Marc Leng;Gary Felsenfeld

  • Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding.

    Viktor Brabec;Jan Reedijk;Marc Leng

  • GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.

    Francine Toulmé;Christine Mosrin-Huaman;Jason Sparkowski;Asis Das

  • Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene

    Evelyne Sage;Marc Leng

  • DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II).

    Viktor Brabec;Miroslav Sip;Marc Leng

  • Interaction of spermine and DNA

    Shalom Z. Hirschman;Marc Leng;Gary Felsenfeld

  • Transcription by eucaryotic and procaryotic RNA polymerases of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II).

    Yves Corda;Claudette Job;Marie-France Anin;Marc Leng

  • Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.

    Marc Boudvillain;Rozenn Dalbiès;Christophe Aussourd;Marc Leng

  • Interaction between antibodies to Z-form deoxyribonucleic acid and double-stranded polynucleotides.

    Bernard Malfoy;Nicolle Rousseau;Marc Leng

  • NMR solution structure of a DNA decamer containing an interstrand cross-link of the antitumor drug cis-diamminedichloroplatinum (II).

    Françoise Paquet;C. Perez;M. Leng;G. Lancelot

  • Solvation of the left-handed hexamer d(5BrC-G-5BrC-G-5BrC-G) in crystals grown at two temperatures

    B. Chevrier;A.C. Dock;B. Hartmann;M. Leng

  • The B→Z transition of poly (dG–dC).poly(dG–dC) modified by some platinum derivatives

    Bernard Malfoy;Brighte Hartmann;Marc Leng

  • DNA double helix promotes a linkage isomerization reaction in trans-diamminedichloroplatinum(II)-modified DNA.

    Rozenn Dalbies;Dominique Payet;Marc Leng

  • Biophysical analysis of DNA modified by 1,2-diaminocyclohexane platinum(II) complexes

    Vladimir Boudný;Oldrich Vrána;Frederic Gaucheron;Vladimir Kleinwachter

Frequent Co-Authors

Robert P. P. Fuchs
Robert P. P. Fuchs Centre national de la recherche scientifique, CNRS
Viktor Brabec
Viktor Brabec Czech Academy of Sciences
Claude Hélène
Claude Hélène Grenoble Alpes University
Philippe Kourilsky
Philippe Kourilsky Collège de France
Bernard Lebleu
Bernard Lebleu University of Montpellier
Bernhard Lippert
Bernhard Lippert TU Dortmund University
Richard Lavery
Richard Lavery Claude Bernard University Lyon 1
Bernard Dutrillaux
Bernard Dutrillaux Sorbonne University
Dominique Job
Dominique Job Centre national de la recherche scientifique, CNRS
Giovanni Natile
Giovanni Natile University of Bari Aldo Moro

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