His main research concerns DNA, Stereochemistry, Biochemistry, Base pair and Guanine. The various areas that he examines in his DNA study include Adduct and Nucleotide. His Stereochemistry research includes elements of Polynucleotide and Carcinogen.
His study on Transcription factor II D, Coding strand, RNA polymerase II and Transcription bubble is often connected to D-loop as part of broader study in Biochemistry. His research investigates the connection between Base pair and topics such as Crystallography that intersect with problems in Molecule and A-DNA. His Oligonucleotide research focuses on Nucleic acid and how it connects with Nucleic acid structure, Molecular biology, Bifunctional, Stereoisomerism and Steric effects.
Marc Leng spends much of his time researching DNA, Stereochemistry, Biochemistry, Guanine and Oligonucleotide. His DNA study combines topics in areas such as Molecular biology, Adduct, In vitro and Nucleic acid. His Stereochemistry research is multidisciplinary, incorporating perspectives in Gel electrophoresis, Polynucleotide, Platinum and Nucleotide.
His study connects Helix and Biochemistry. His Guanine study which covers Imidazole that intersects with Amine gas treating. As a member of one scientific family, Marc Leng mostly works in the field of Oligonucleotide, focusing on RNA and, on occasion, Polymerase.
His scientific interests lie mostly in DNA, Oligonucleotide, Stereochemistry, Adduct and Biochemistry. His DNA research incorporates themes from Bifunctional, Molecular biology, In vitro and Guanine. His Oligonucleotide research incorporates elements of Cleavage, RNA, Duplex, Nucleotide and Combinatorial chemistry.
His work carried out in the field of Stereochemistry brings together such families of science as Ribonucleotide, Cytosine, Residue, Platinum and In vivo. His Adduct research is multidisciplinary, relying on both Nucleic acid and Isomerization. In his work, Nuclear magnetic resonance spectroscopy, A-DNA and Chemical shift is strongly intertwined with Crystallography, which is a subfield of Base pair.
Marc Leng mainly focuses on DNA, Stereochemistry, Base pair, Oligonucleotide and Adduct. His DNA research is multidisciplinary, incorporating perspectives in Platinum, Mutant, Guanine and RNA polymerase. His Stereochemistry study integrates concerns from other disciplines, such as Cytosine, In vitro and In vivo.
His Base pair research focuses on subjects like Crystallography, which are linked to Two-dimensional nuclear magnetic resonance spectroscopy and A-DNA. Oligonucleotide is the subject of his research, which falls under Biochemistry. His Adduct research integrates issues from Bifunctional, Footprinting, Gel electrophoresis and Pyrimidine.
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DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.
Viktor Brabec;Marc Leng.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity.
Jewel T. Shapiro;Marc Leng;Gary Felsenfeld.
Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.
Paul Tchen;Robert P. P. Fuchs;Evelyne Sage;Marc Leng.
Proceedings of the National Academy of Sciences of the United States of America (1984)
Interstrand cross-links are preferentially formed at the d(GC) sites in the reaction between cis-diamminedichloroplatinum (II) and DNA.
M A Lemaire;A Schwartz;A R Rahmouni;M Leng.
Proceedings of the National Academy of Sciences of the United States of America (1991)
Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 Å resolution: Hydration at the platinated site
Franck Coste;Jean-Marc Malinge;Laurence Serre;William Shepard.
Nucleic Acids Research (1999)
Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding.
Viktor Brabec;Jan Reedijk;Marc Leng.
Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene
Evelyne Sage;Marc Leng.
Proceedings of the National Academy of Sciences of the United States of America (1980)
GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.
Francine Toulmé;Christine Mosrin-Huaman;Jason Sparkowski;Asis Das.
The EMBO Journal (2000)
DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II).
Viktor Brabec;Miroslav Sip;Marc Leng.
Transcription by eucaryotic and procaryotic RNA polymerases of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II).
Yves Corda;Claudette Job;Marie-France Anin;Marc Leng.
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