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Medicine

D-Index
97
Citations
31138
World Ranking
9375
National Ranking
4834

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen B. Howell is affiliated with the University of California, San Diego in the United States. Their research spans multiple areas in medicine, with significant outputs in biochemistry, genetics, and molecular biology. The scientist's work intersects several subfields including molecular biology, oncology, hematology, genetics, and immunology.

The primary topics explored in their research include:

  • Chronic Lymphocytic Leukemia Research
  • Immunotherapy and Immune Responses
  • Acute Myeloid Leukemia Research
  • Cancer Immunotherapy and Biomarkers
  • Lymphoma Diagnosis and Treatment
  • Chronic Myeloid Leukemia Treatments
  • Cancer Cells and Metastasis

Howell's publication record features articles in established scientific journals, particularly in cancer and hematology fields. Frequent venues for their research include:

  • Cancer Research
  • Blood
  • Journal of Translational Medicine
  • Bioconjugate Chemistry
  • PLoS ONE

Notable recent papers by Howell demonstrate a focus on cancer immunotherapy and molecular targets in hematologic malignancies and solid tumors. Selected papers include:

  • "Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer" (2020), Journal of Translational Medicine
  • "A Phase 1a/b Dose Escalation Study of the MYC Repressor Apto-253 in Patients with Relapsed or Refractory AML or High-Risk MDS" (2021), Blood
  • "Therapeutic Targeting of Tumor Cells Rich in LGR Stem Cell Receptors" (2021), Bioconjugate Chemistry
  • "WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer" (2020), Anticancer Research
  • "Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia" (2022), Molecular Cancer Therapeutics

Collaborations have been an integral part of Howell's research endeavors, with frequent coauthors including William G. Rice, Nasrin Rastgoo, Rafael Bejar, Khalid Benbatoul, and Yuying Jin. These partnerships reflect interdisciplinary engagement within oncology and hematology research communities.

Stephen B. Howell was recognized in 2015 as a Fellow of the American Association for the Advancement of Science (AAAS), acknowledging contributions to the scientific field. Their continued research activity contributes to the understanding of molecular and therapeutic aspects of cancer and blood disorders.

Best Publications

  • The role of DNA mismatch repair in platinum drug resistance.

    Daniel Fink;Sibylle Nebel;Stefan Aebi;Hua Zheng

  • The role of DNA mismatch repair in drug resistance.

    Daniel Fink;Stefan Aebi;Stephen B. Howell

  • Loss of DNA mismatch repair in acquired resistance to cisplatin.

    S Aebi;B Kurdi-Haidar;R Gordon;B Cenni

  • Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells

    Roohangiz Safaei;Barrett J. Larson;Timothy C. Cheng;Michael A. Gibson

  • A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.

    Michael J. Glantz;Michael J. Glantz;Kurt A. Jaeckle;Marc C. Chamberlain;Surasak Phuphanich

  • Intraperitoneal Cisplatin with Systemic Thiosulfate Protection

    Stephen B. Howell;Craig L. Pfeifle;Wally E. Wung;Richard A. Olshen

  • Mismatch repair proficiency and in vitro response to 5-fluorouracil

    John M. Carethers;Dharam P. Chauhan;Daniel Fink;Sibylle Nebel

  • Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells

    Goli Samimi;Roohangiz Safaei;Kuniyuki Katano;Alison K. Holzer

  • Randomized Trial of a Slow-Release Versus a Standard Formulation of Cytarabine for the Intrathecal Treatment of Lymphomatous Meningitis

    Michael J. Glantz;Suzanne LaFollette;Kurt A. Jaeckle;William Shapiro

  • Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin

    Alison K. Holzer;Gerald H. Manorek;Stephen B. Howell

  • Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.

    Kuniyuki Katano;Akira Kondo;Roohangiz Safaei;Alison Holzer

  • In Vitro and in Vivo Resistance to Cisplatin in Cells That Have Lost DNA Mismatch Repair

    Daniel Fink;Hua Zheng;Sibylle Nebel;Paula S. Norris

  • Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs.

    Roohangiz Safaei;Stephen B. Howell

  • The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae.

    Xinjian Lin;Tsuyoshi Okuda;Alison Holzer;Stephen B. Howell

  • Porous Silicon Nanoparticle Photosensitizers for Singlet Oxygen and Their Phototoxicity Against Cancer Cells

    Ling Xiao;Luo Gu;Stephen B. Howell;Michael J. Sailor

  • The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells

    Alison K Holzer;Goli Samimi;Kuniyuki Katano;Wiltrud Naerdemann

  • Long-Term Survival of Advanced Refractory Ovarian Carcinoma Patients with Small-Volume Disease Treated with Intraperitoneal Chemotherapy

    Stephen B. Howell;Soloman Zimm;Maurie Markman;Ian S. Abramson

  • Differential Potentiation of Alkylating and Platinating Agent Cytotoxicity in Human Ovarian Carcinoma Cells by Glutathione Depletion

    Paul A. Andrews;Michael P. Murphy;Stephen B. Howell

  • A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors.

    Jeany M. Rademaker-Lakhai;Catherine Terret;Stephen B. Howell;Christiane M. Baud

  • Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients

    K. Thomas Robbins;Parvesh Kumar;Frank S. H. Wong;William F. Hartsell

Frequent Co-Authors

Maurie Markman
Maurie Markman The University of Texas MD Anderson Cancer Center
Marc C. Chamberlain
Marc C. Chamberlain University of Washington
Michael J. Sailor
Michael J. Sailor University of California, San Diego
Nathan C. Gianneschi
Nathan C. Gianneschi Northwestern University
John Mendelsohn
John Mendelsohn The University of Texas at Austin
Paola Perego
Paola Perego University of Milan
Erkki Ruoslahti
Erkki Ruoslahti Sanford Burnham Prebys Medical Discovery Institute
Nissi M. Varki
Nissi M. Varki University of California, San Diego
Olivier Harismendy
Olivier Harismendy University of California, San Diego
Shannon K. McWeeney
Shannon K. McWeeney Oregon Health & Science University

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