World's Best Scientists 2026 revealed!

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Chemistry

D-Index
46
Citations
8530
World Ranking
15956
National Ranking
3985

Overview

Heebyung Chai is affiliated with The Ohio State University in the United States. Their research portfolio includes work focused on pharmacology, biomaterials, and rehabilitation, reflecting multidisciplinary engagement across these subfields.

The scientist's work centers on pharmacological effects of natural compounds as well as phytochemistry and bioactive compounds, with particular emphasis on Magnolia and Illicium plant research. These topics are covered in all documented publications to date.

Heebyung Chai has contributed to publications in the following venues:

  • Bioorganic & Medicinal Chemistry
  • Journal of Materials Chemistry B

Among the notable papers authored, two stand out:

  • "Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper" (2020, Bioorganic & Medicinal Chemistry)
  • "A pH-responsive anthocyanin-based hydrogel with colorimetric infection monitoring and antibacterial properties for wound healing" (2025, Journal of Materials Chemistry B)

This work reveals a range of research interests, from natural product pharmacology to biomaterials with biomedical applications.

Heebyung Chai has collaborated with several researchers, including:

  • Yulin Ren
  • Qing-Wei Tan
  • Kimberly N. Heath
  • Sijin Wu
  • James R. Wilson

Best Publications

  • Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

    E Pisha;H Chai;I S Lee;T E Chagwedera

  • The relevance of higher plants in lead compound discovery programs.

    A. Douglas Kinghorn;Li Pan;Joshua N. Fletcher;Heebyung Chai

  • Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

    Bang Yeon Hwang;Bao Ning Su;Heebyung Chai;Qiuwen Mi

  • Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile

    Kittisak Likhitwitayawuid;Cindy K. Angerhofer;Heebyung Chai;John M. Pezzuto

  • Lignans and Other Constituents of the Fruits of Euterpe oleracea (Açai) with Antioxidant and Cytoprotective Activities

    Young-Won Chin;Hee-Byung Chai;William J. Keller;A. Douglas Kinghorn

  • A Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol

    Hayat Alkan-Onyuksel;Suganthi Ramakrishnan;Hee-Byung Chai;John M. Pezzuto

  • The continuing search for antitumor agents from higher plants

    Li Pan;Heebyung Chai;A. Douglas Kinghorn

  • Chemical and bioactive constituents from Zanthoxylum simulans

    Ih Sheng Chen;Shwu Jen Wu;Ian Lih Tsai;Tian Shung Wu

  • Cytotoxic biflavonoids from Selaginella willdenowii

    Gloria L. Silva;Heebyung Chai;Mahabir P. Gupta;Norman R. Farnsworth

  • Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots

    Ye Deng;Young-Won Chin;Heebyung Chai;William J Keller

  • Diterpenes from the berries of Juniperus excelsa.

    Gülaçti Topçu;Ramazan Erenler;Osman Çakmak;Candan Bozok Johansson

  • (-)-Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells.

    M You;D B Wickramaratne;G L Silva;H Chai

  • Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei.

    Kittisak Likhitwitayawuid;Cindy K. Angerhofer;Heebyung Chai;John M. Pezzuto

  • Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).

    Young-Won Chin;Hyun-Ah Jung;Heebyung Chai;William J. Keller

  • Bioactive constituents of Helianthus tuberosus (Jerusalem artichoke)

    Li Pan;Michelle R. Sinden;Aaron H. Kennedy;Heebyung Chai

  • Preparation of amino acid conjugates of betulinic acid with activity against human melanoma.

    Hyeh-Jean Jeong;Hee-Byung Chai;So-Young Park;Darrick S.H.L Kim

  • Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.

    Fredyc Díaz;Daniel Chávez;Dongho Lee;Qiuwen Mi

  • Silvestrol, a Potential Anticancer Rocaglate Derivative from Aglaia foveolata, Induces Apoptosis in LNCaP Cells through the Mitochondrial/Apoptosome Pathway without Activation of Executioner Caspase-3 or -7

    Soyoung Kim;Bang Yeon Hwang;Bao-Ning Su;Heebyung Chai

  • Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry).

    Hideyuki Tomosaka;Young-Won Chin;Angela A. Salim;William J. Keller

  • Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia

    Jian Qiao Gu;Tyler N. Graf;Dongho Lee;Hee Byung Chai

  • Resveratrol Tetramers from Vatica diospyroides

    Eun Kyoung Seo;Heebyung Chai;Howard L. Constant;Thawatchai Santisuk

  • Structure and stereochemistry of pectinolides A-C, novel antimicrobial and cytotoxic 5,6-dihydro-α-pyrones from Hyptis pectinata

    Rogelio Pereda-Miranda;Lourdes Hernández;Manuela Judith Villavicencio;Miriam Novelo

  • Lycorine alkaloids from Hymenocallis littoralis

    Long-Ze Lin;Shu-Fang Hu;Hee-Byung Chai;Thitima Pengsuparp

Frequent Co-Authors

A. Douglas Kinghorn
A. Douglas Kinghorn The Ohio State University
John M. Pezzuto
John M. Pezzuto Western New England University
Geoffrey A. Cordell
Geoffrey A. Cordell University of Florida
Norman R. Farnsworth
Norman R. Farnsworth University of Illinois at Chicago
Bernard D. Santarsiero
Bernard D. Santarsiero University of Illinois at Chicago
Roberto R. Gil
Roberto R. Gil Carnegie Mellon University
Mansukh C. Wani
Mansukh C. Wani Research Triangle Park Foundation
James R. Fuchs
James R. Fuchs The Ohio State University
Harry H. S. Fong
Harry H. S. Fong University of Illinois at Chicago
Andrew D. Mesecar
Andrew D. Mesecar Purdue University West Lafayette

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