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Chemistry

D-Index
42
Citations
8210
World Ranking
17412
National Ranking
65

Overview

Gulacti Topcu is affiliated with Istanbul Technical University in Turkey. Their research spans key areas within Agricultural and Biological Sciences and Biochemistry, Genetics and Molecular Biology. Topcu's work notably includes molecular biology, plant science, food science, pharmacology, and organic chemistry, reflecting a multidisciplinary approach to natural product research and biochemistry.

Their research topics emphasize phytochemistry and biological activities, essential oils and antimicrobial activity, natural product bioactivities and synthesis, and cholinesterase and neurodegenerative diseases. Computational drug discovery methods and seaweed-derived bioactive compounds are also significant areas of study, alongside plant biochemistry and biosynthesis.

Topcu has contributed to the scientific community through publications in several prominent venues. These include Records of Natural Products, International Journal of Gynecology & Obstetrics, Chemistry & Biodiversity, Pharmaceutical Biology, and Organic Communications.

Frequent collaborators include Halil Şenol, Gülbahar Özge Alim Toraman, Ahmet C. Gören, Ebru Erol, and Michael Geary. Such collaborations have contributed to a body of work that incorporates various aspects of natural product research and medicinal chemistry.

Some recent publications authored or co-authored by Gulacti Topcu include:

  • Synthesis and Anticancer Activity of Novel Derivatives of α,β-Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer Cells, 2023, Chemistry & Biodiversity
  • Cytotoxic meroterpenoids from brown alga Stypopodium schimperi (Kützing) Verlaque & Boudouresque with comprehensive molecular docking & dynamics and ADME studies, 2023, Process Biochemistry
  • Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors, 2023, Medicinal Chemistry Research
  • Selective in-vitro Enzymes' Inhibitory Activities of Fingerprints Compounds of Salvia Species and Molecular Docking Simulations., 2020, PubMed
  • Synthesis of new fatty acid derivatives of oleanane and ursane triterpenoids and investigation of their in vitro cytotoxic effects on 3T3 fibroblast and PC3 prostate cancer cell linesLines, 2020, Organic Communications

Best Publications

  • Antioxidant activity of stem and root extracts of Rhubarb (Rheum ribes) : An edible medicinal plant

    Mehmet Öztürk;Mehmet Öztürk;Fatma Aydoğmuş-Öztürk;Mehmet Emin Duru;Gülaçtı Topçu

  • Terpenoids from Salvia sclarea

    A Ulubelen;G Topcu;C Eriş;U Sönmez

  • Antimicrobial activity of propolis samples from two different regions of Anatolia.

    Murat Kartal;Sulhiye Yıldız;Serdar Kaya;Semra Kurucu

  • A new flavone from antioxidant extracts of Pistacia terebinthus

    Gülaçtı Topçu;Mehmet Ay;Ali Bilici;Cengiz Sarıkürkcü

  • Bioactive triterpenoids from Salvia species.

    Gülaçti Topçu

  • Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia

    İbrahim Kivrak;Mehmet Emin Duru;Mehmet Öztürk;Nazime Mercan

  • Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.

    Ayhan Ulubelen;Gülaçtì Topcu;Candan Bozok Johansson

  • Antioxidant abietane diterpenoids from Salvia barrelieri

    Ahmed Kabouche;Zahia Kabouche;Mehmet Öztürk;Mehmet Öztürk;Ufuk Kolak

  • Diterpenes from the berries of Juniperus excelsa.

    Gülaçti Topçu;Ramazan Erenler;Osman Çakmak;Candan Bozok Johansson

  • Studies in Natural Products Chemistry

    Ayhan Ulubelen;Gülaçti Topçu;Ufuk Kolak

  • Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical-scavenging activity-guided fractionation

    Mehmet Öztürk;Mehmet Öztürk;Mehmet Öztürk;Ufuk Kolak;Gülaçtı Topçu;Sevil Öksüz

  • Identification of cytotoxic sesquiterpenes from Laurus nobilis L.

    Aslı Barla;Gülaçtı Topçu;Sevil Öksüz;Gülendam Tümen

  • The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas.

    Ahmet Gören;Gülaçti Topçu;Gökhan Bilsel;Mine Bilsel

  • Antibacterial diterpenes from the roots of Salvia blepharochlaena.

    Ayhan Ulubelen;Sevil Öksüz;Gülaçtı Topcu;and Ahmet C. Gören

  • Brominated sesquiterpenes from the red alga Laurencia obtusa.

    Gulaçti Topcu;Zeynep Aydogmus;Sedat Imre;Ahmet C Gören

  • DNA as an affinity probe useful in the detection and isolation of biologically active natural products.

    John M. Pezzuto;Chun-Tao Che;David D. McPherson;Ji-Ping Zhu

  • Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities.

    Ramazan Erenler;Bilal Meral;Ozkan Sen;Mahfuz Elmastas

  • Antioxidant activity tests on novel triterpenoids from Salvia macrochlamys

    Guelactu Topcu;Abdulselam Ertas;Ufuk Kolak;Mehmet Oeztuerk

  • Evaluation of fruit extracts of six Turkish Juniperus species for their antioxidant, anticholinesterase and antimicrobial activities.

    Mehmet Oztürk;İbrahim Tümen;Aysel Uğur;Fatma Aydoğmuş-Öztürk

  • Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities

    Gülsen Tel;Mehmet Öztürk;Mehmet Emin Duru;Mansur Harmandar

  • Terpenoids and Steroids from the Roots of Salvia blepharochlaena

    Ufuk Kolak;Gülaçti Topçu;Seher Birteksöz;Gülten Ötük

  • Cytotoxic and antibacterial sesquiterpenes from Inula graveolens

    Gülaçti Topçu;Sevil Öksüz;Sevil Öksüz;Hui-Ling Shieh;Geoffrey A. Cordell

Frequent Co-Authors

Ayhan Ulubelen
Ayhan Ulubelen Istanbul University
John M. Pezzuto
John M. Pezzuto Western New England University
Geoffrey A. Cordell
Geoffrey A. Cordell University of Florida
Wolfgang Voelter
Wolfgang Voelter University of Tübingen
M. Iqbal Choudhary
M. Iqbal Choudhary University of Karachi
Chun-Tao Che
Chun-Tao Che University of Illinois at Chicago
Hildebert Wagner
Hildebert Wagner Ludwig-Maximilians-Universität München
Lutfun Nahar
Lutfun Nahar Liverpool John Moores University
Heebyung Chai
Heebyung Chai The Ohio State University

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