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Medicine

D-Index
73
Citations
22047
World Ranking
19605
National Ranking
1768

Overview

P. Nigel Leigh is affiliated with Brighton and Sussex Medical School in the United Kingdom. Their research focuses primarily on the field of medicine, with specialized work in neurology and related subfields including molecular biology, genetics, physiology, and complementary and alternative medicine.

The scientist's recent publications reflect engagements with neurological diseases, particularly neurodegenerative disorders. Key recent papers include:

  • Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study, 2020, The Lancet Neurology
  • Neurofilament light levels predict clinical progression and death in multiple system atrophy, 2022, Brain
  • Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis, 2020, Brain Communications
  • Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials, 2023, Brain
  • Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2, 2021, Brain Communications

Frequent coauthors working with Nigel Leigh include James B. Rowe, Huw R. Morris, Alistair Church, Joshua Shulman, and Edwin Jabbari. These collaborations encompass a range of studies related to neurological conditions and their underlying mechanisms.

Publication venues where Nigel Leigh often contributes include:

  • The Lancet Neurology
  • Brain
  • Brain Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Medicine

The main research fields and subfields connected to Leigh's work are:

  • Medicine
  • Neurology
  • Molecular Biology
  • Genetics
  • Physiology
  • Complementary and alternative medicine

The scientific topics covered in their research span a wide spectrum within neurology, with particular focus on:

  • Parkinson's Disease Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Neurological diseases and metabolism
  • Neurogenetic and Muscular Disorders Research
  • RNA Research and Splicing
  • Neurological disorders and treatments
  • Prion Diseases and Protein Misfolding

Best Publications

  • TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

    Jemeen Sreedharan;Ian P. Blair;Vineeta B. Tripathi;Xun Hu

  • Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

    Caroline Vance;Boris Rogelj;Tibor Hortobágyi;Kurt J. De Vos

  • Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

    Michael J. Strong;Gloria M. Grace;Morris Freedman;Cathy Lomen-Hoerth

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Biomarkers in amyotrophic lateral sclerosis.

    Martin R Turner;Matthew C Kiernan;P Nigel Leigh;Kevin Talbot

  • Deletions of the Heavy Neurofilament Subunit Tail in Amyotrophic Lateral Sclerosis

    Ammar Al-Chalabi;Peter M. Andersen;Peter Nilsson;Barry Chioza

  • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.

    Michael A van Es;Jan H Veldink;Christiaan G J Saris;Hylke M Blauw

  • Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

    Kurt J. De Vos;Kurt J. De Vos;Anna L. Chapman;Maria E. Tennant;Catherine Manser

  • A proposed staging system for amyotrophic lateral sclerosis.

    Jose C. Roche;Ricardo Rojas-Garcia;Ricardo Rojas-Garcia;Kirsten M. Scott;William Scotton

  • Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

    Ammar Al-Chalabi;Andrea Calvo;Adriano Chio;Shuna Colville

  • Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study

    Gilbert Bensimon;Albert Ludolph;Yves Agid;Marie Vidailhet

  • Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

    Claire L. Simpson;Robin Lemmens;Robin Lemmens;Katarzyna Miskiewicz;Katarzyna Miskiewicz;Wendy J. Broom

  • NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

    Kevin P Kenna;Perry T C van Doormaal;Annelot M Dekker;Nicola Ticozzi

  • Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses.

    Sharon Abrahams;Laura H. Goldstein;Andy Simmons;Michael J. Brammer

  • Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London.

    Clare A. Johnston;Biba R. Stanton;Biba R. Stanton;Martin R. Turner;Rebecca Gray

  • Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

    Aleksey Shatunov;Kin Mok;Stephen Newhouse;Michael E Weale

  • Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

    Janet Brownlees;Steven Ackerley;Andrew J. Grierson;Nick J.O. Jacobsen

  • Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments

    Steven Ackerley;Paul Thornhill;Andrew J. Grierson;Janet Brownlees

  • Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

    Ton Fang;Ahmad Al Khleifat;Jacques-Henri Meurgey;Ashley Jones

  • Supporting Online Material for Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

    Caroline Vance;Boris Rogelj;Tibor Hortobágyi;Kurt J. De Vos

Frequent Co-Authors

Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Christopher Shaw
Christopher Shaw King's College London
Martin R. Turner
Martin R. Turner University of Oxford
Pamela J. Shaw
Pamela J. Shaw University of Sheffield
Laura H. Goldstein
Laura H. Goldstein King's College London
Robert H. Brown
Robert H. Brown University of Massachusetts Chan Medical School
Karen E. Morrison
Karen E. Morrison University of Southampton
Orla Hardiman
Orla Hardiman Trinity College Dublin
John Landers
John Landers University of Massachusetts Chan Medical School
Christopher C. J. Miller
Christopher C. J. Miller King's College London

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