What is he best known for?
The fields of study he is best known for:
His primary areas of study are Mitochondrial DNA, Mitochondrion, Molecular biology, Genetics and Apoptosis.
His work deals with themes such as Mutation, Mutation, Disease, Ageing and Programmed cell death, which intersect with Mitochondrial DNA.
His Mitochondrion study improves the overall literature in Biochemistry.
The concepts of his Molecular biology study are interwoven with issues in Germline mutation, Somatic cell, DNA, Hot start PCR and Polymerase chain reaction.
When carried out as part of a general Genetics research project, his work on Phenotype, Ribosome, Gene and Backcrossing is frequently linked to work in Noise-induced hearing loss, therefore connecting diverse disciplines of study.
His Apoptosis research is multidisciplinary, incorporating perspectives in Intracellular and Cell biology.
His most cited work include:
- Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. (953 citations)
- Detection of a specific mitochondrial DNA deletion in tissues of older humans (672 citations)
- A simple method for site-directed mutagenesis using the polymerase chain reaction (539 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Mitochondrion, Molecular biology, Mitochondrial DNA, Genetics and Cell biology.
His studies in Mitochondrion integrate themes in fields like Apoptosis, Programmed cell death and Mitochondrial disease.
Gino A Cortopassi works mostly in the field of Molecular biology, limiting it down to topics relating to Mutant and, in certain cases, Chromosomal translocation.
He works mostly in the field of Mitochondrial DNA, limiting it down to topics relating to Somatic cell and, in certain cases, Carcinogenesis, as a part of the same area of interest.
In his research, Dorsal root ganglion and Substantia nigra is intimately related to Neurodegeneration, which falls under the overarching field of Cell biology.
His Biochemistry study combines topics in areas such as Endocrinology and Internal medicine.
He most often published in these fields:
- Mitochondrion (35.09%)
- Molecular biology (25.15%)
- Mitochondrial DNA (22.81%)
What were the highlights of his more recent work (between 2017-2021)?
- Pharmacology (9.36%)
- Cancer research (9.94%)
- Mitochondrion (35.09%)
In recent papers he was focusing on the following fields of study:
Pharmacology, Cancer research, Mitochondrion, Inflammation and Internal medicine are his primary areas of study.
His Cancer research research also works with subjects such as
- mTORC1 which connect with Mechanistic target of rapamycin,
- Cytotoxicity which is related to area like Cancer stem cell, Glioma, Apoptosis, Caspase 3 and Reactive oxygen species.
In his work, Frataxin, Oxidative stress and Mitochondrial biogenesis is strongly intertwined with Ataxia, which is a subfield of Mitochondrion.
He interconnects Epithelium, Toxicity and Cell biology in the investigation of issues within Inflammation.
Gino A Cortopassi works mostly in the field of Internal medicine, limiting it down to topics relating to Endocrinology and, in certain cases, Oxidative phosphorylation, Candesartan and Affect.
His research integrates issues of Aconitase, Mitochondrial disease, Mitochondrial DNA, Molecular biology and Cytochrome c oxidase in his study of Dimethyl fumarate.
Between 2017 and 2021, his most popular works were:
- Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative. (18 citations)
- Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia. (12 citations)
- Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. (9 citations)
In his most recent research, the most cited papers focused on:
Gino A Cortopassi mainly investigates Mitochondrion, Cell biology, Pharmacology, Inflammation and Cancer cell.
His Mitochondrion research includes elements of Ataxia, Gene expression, Gene and Molecular biology.
His studies deal with areas such as Epithelium, Gut Epithelium, Immunodeficiency, T cell and Immunity as well as Cell biology.
Gino A Cortopassi combines subjects such as Mechanistic target of rapamycin, Small molecule, In vivo and mTORC2 with his study of Pharmacology.
His Inflammation research incorporates elements of NADPH oxidase, Endocrinology, Senescence and Simian immunodeficiency virus.
His Cancer cell research is multidisciplinary, relying on both mTORC1, PI3K/AKT/mTOR pathway, In vitro and Caspase 3.
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