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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
18428
World Ranking
6634
National Ranking
50

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Lea Sistonen is affiliated with Åbo Akademi University in Finland and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology and Cell Biology. Their research encompasses a range of subfields including Cancer Research, Genetics, and Immunology and Allergy.

Their work prominently addresses topics related to Heat shock proteins research, Endoplasmic Reticulum Stress and Disease, RNA Research and Splicing, as well as Genomics and Chromatin Dynamics. Additionally, Cellular Mechanics and Interactions, Cell Adhesion Molecules Research, and Ubiquitin and proteasome pathways have been significant areas of study.

Lea Sistonen has published several papers in notable journals. Recent selected publications include:

  • "Therapeutic Potential of Targeting the SUMO Pathway in Cancer," 2021, Cancers
  • "Molecular Mechanisms of Heat Shock Factors in Cancer," 2020, Cells
  • "Transcriptional reprogramming at the intersection of the heat shock response and proteostasis," 2023, Molecular Cell
  • "Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions," 2021, Molecular Cell
  • "Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion," 2020, Cell Reports

Their frequent co-authors include Anniina Vihervaara, Mikael C. Puustinen, Alejandro J. Da Silva, Jenny C. Pessa, and Jenny Joutsen, suggesting ongoing collaborations across various projects.

Lea Sistonen's work is regularly published in several key venues, such as bioRxiv (Cold Spring Harbor Laboratory), Cell Stress and Chaperones, FEBS Journal, Molecular Cell, and Nature Communications.

Among their recognitions, Lea Sistonen is a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Heat shock factors: integrators of cell stress, development and lifespan

    Malin Åkerfelt;Richard I. Morimoto;Lea Sistonen

  • Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

    Lila Pirkkala;Lila Pirkkala;Päivi Nykänen;Lea Sistonen

  • Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

    Julius Anckar;Lea Sistonen

  • Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

    Sandy D. Westerheide;Julius Anckar;Stanley M. Stevens;Lea Sistonen

  • PDSM, a motif for phosphorylation-dependent SUMO modification.

    Ville Hietakangas;Julius Anckar;Henri A. Blomster;Mitsuaki Fujimoto

  • Effect of sodium salicylate on the human heat shock response

    Donald A. Jurivich;Lea Sistonen;Roger A. Kroes;Richard I. Morimoto

  • Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

    Carina I. Holmberg;Ville Hietakangas;Andrey Mikhailov;Jouni O. Rantanen

  • Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.

    Ville Hietakangas;Johanna K. Ahlskog;Annika M. Jakobsson;Maria Hellesuo

  • Multisite phosphorylation provides sophisticated regulation of transcription factors.

    Carina I Holmberg;Stefanie E.F Tran;John E Eriksson;Lea Sistonen

  • Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

    Lea Sistonen;Kevin D. Sarge;Benette Phillips;Klara Abravaya

  • HSF1 at a glance.

    Anniina Vihervaara;Lea Sistonen

  • Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.

    Lea Sistonen;Kevin D. Sarge;Richard I Morimoto

  • Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.

    L Pertovaara;L Sistonen;T J Bos;P K Vogt

  • Heat Shock Factor 2 (HSF2) Contributes to Inducible Expression of hsp Genes through Interplay with HSF1

    Päivi Östling;Johanna K. Björk;Pia Roos-Mattjus;Valérie Mezger

  • Heat Shock Factors at a Crossroad between Stress and Development

    Malin Åkerfelt;Diane Trouillet;Valérie Mezger;Lea Sistonen

  • Characterization of a hypoxia-inducible factor (HIF-1alpha ) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension.

    Arto J. Soitamo;Christina M.I. Råbergh;Max Gassmann;Lea Sistonen

  • The ubiquitin-proteasome pathway.

    Pia Roos-Mattjus;Lea Sistonen

  • Antiproliferative prostaglandins activate heat shock transcription factor.

    C Amici;L Sistonen;M G Santoro;R I Morimoto

  • Heat shock factor 1 as a coordinator of stress and developmental pathways.

    Julius Anckar;Lea Sistonen

  • Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice

    Marko Kallio;Marko Kallio;Yunhua Chang;Martine Manuel;Martine Manuel;Tero-Pekka Alastalo

Frequent Co-Authors

John E. Eriksson
John E. Eriksson Åbo Akademi University
Kari Alitalo
Kari Alitalo University of Helsinki
Richard I. Morimoto
Richard I. Morimoto Northwestern University
Kai Kaarniranta
Kai Kaarniranta University of Eastern Finland
Mikko Nikinmaa
Mikko Nikinmaa University of Turku
Mikko J. Lammi
Mikko J. Lammi Umeå University
Kevin D. Sarge
Kevin D. Sarge University of Kentucky
Jorma Keski-Oja
Jorma Keski-Oja University of Helsinki
Jorma J. Palvimo
Jorma J. Palvimo University of Eastern Finland
Kaisa Granfors
Kaisa Granfors University of Turku

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