Kevin D. Sarge

Overview

Best Publications

• Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

  Kevin D. Sarge;Shawn P. Murphy;Richard I. Morimoto

  1312
  Citations

• Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

  Richard I Morimoto;Kevin D. Sarge;Klara Abravaya

  578
  Citations

• Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability

  Kevin D. Sarge;Vincenzo Zimarino;Karin Holm;Carl Wu

  465
  Citations

• In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation.

  Dick D. Mosser;Paul T. Kotzbauer;Kevin D. Sarge;Richard I. Morimoto

  406
  Citations

• Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

  Lea Sistonen;Kevin D. Sarge;Benette Phillips;Klara Abravaya

  369
  Citations

• Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification.

  Yiling Hong;Richard Rogers;Michael J. Matunis;Christopher N. Mayhew

  325
  Citations

• Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.

  Lea Sistonen;Kevin D. Sarge;Richard I Morimoto

  311
  Citations

• Characterization of the stress-inducing effects of homocysteine.

  P. A. Outinen;S. K. Sood;P. C. Y. Liaw;K. D. Sarge

  297
  Citations

• Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis.

  Kevin D. Sarge;Ok-Kyong Park-Sarge;John D. Kirby;Kelly E. Mayo

  259
  Citations

• Arachidonate is a potent modulator of human heat shock gene transcription.

  Donald A. Jurivich;Lea Sistonen;Kevin D. Sarge;Richard I. Morimoto

  219
  Citations

• SUMO-1 Modification Regulates the DNA Binding Activity of Heat Shock Transcription Factor 2, a Promyelocytic Leukemia Nuclear Body Associated Transcription Factor *

  Michael L. Goodson;Yiling Hong;Richard Rogers;Michael J. Matunis

  214
  Citations

• Mechanism of hsp70i Gene Bookmarking

  Hongyan Xing;Donald C. Wilkerson;Christopher N. Mayhew;Christopher N. Mayhew;Eric J. Lubert;Eric J. Lubert

  202
  Citations

• Sumoylation and human disease pathogenesis.

  Kevin D. Sarge;Ok-Kyong Park-Sarge

  195
  Citations

• Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

  Yu-Qian Zhang;Kevin D. Sarge

  182
  Citations

• Regulation and Function of SUMO Modification

  Roland S. Hilgarth;Lynea A. Murphy;Hollie S. Skaggs;Donald C. Wilkerson

  172
  Citations

• Quercetin Inhibits Heat Shock Protein Induction but Not Heat Shock Factor DNA-Binding in Human Breast Carcinoma Cells

  R.K. Hansen;S. Oesterreich;S. Oesterreich;P. Lemieux;P. Lemieux;K.D. Sarge;K.D. Sarge

  153
  Citations

• Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1.

  Timothy W. Fawcett;Sherrie L. Sylvester;Kevin D. Sarge;Richard I Morimoto

  152
  Citations

• Age-related alterations in the activation of heat shock transcription factor 1 in rat hepatocytes.

  Ahmad R. Heydari;Shenghong You;Ryoya Takahashi;Astrid Gutsmann-Conrad

  150
  Citations

• Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels

  Yu-Qian Zhang;Kevin D. Sarge

  142
  Citations

• Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element.

  Paul E. Kroeger;Kevin D. Sarge;Richard I. Morimoto

  138
  Citations